Compounds > mephenytoin
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mephenytoin and Epilepsy

mephenytoin has been researched along with Epilepsy in 64 studies

Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"This report describes a patient who developed marked generalized adenopathy and nephrotic syndrome while receiving mephenytoin (mesantoin) for a seizure disorder."7.65Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity. ( Hayslett, J; Siegel, N; Snead, C, 1976)
"This report describes a patient who developed marked generalized adenopathy and nephrotic syndrome while receiving mephenytoin (mesantoin) for a seizure disorder."3.65Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity. ( Hayslett, J; Siegel, N; Snead, C, 1976)
"Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912."1.38How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)? ( Bialer, M, 2012)
"Mean mephenytoin level was 8% of the combined mephenytoin plus nirvanol levels."1.26Mephenytoin: a reappraisal. ( Dodrill, CB; Ojemann, LM; Troupin, AS, 1976)

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-199063 (98.44)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (1.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aird, RB1
MOSOVICH, A1
RICKLES, NK1
PULLAR-STRECKER, H1
MYERS, HJ1
ARIEFF, AJ1
FETTERMAN, JL3
VICTOROFF, VM2
CARTER, HR1
FRIEDMAN, MD1
KOZOL, HL2
Bialer, M1
WONG, YT1
HAYS, AL1
HILL, TS1
BELSASSO, M1
BONIVENTO, M1
ANDERSSON, B1
HALLEN, O2
MALLIN, AW2
GAMMON, GD2
ABBOTT, JA1
SCHWAB, RS1
FUGLSANG-FREDERIKSEN, V1
BARO, WZ1
LA GRUTTA, G1
KLOPP, HW2
WISE, RA1
HEUMANN, WA1
GONZALEZ GUIJA, A1
DOYLE, AP1
HELLSTROM, HR1
GRIESSHABER, W1
BURRELL, ZL1
SOLMS, W1
WALLENTIN, G1
GABRIELSEN, LH1
JESSERER, H1
JONES, DP1
HOLUB, K1
WILD, H1
CHIARI, H1
WEINMANN, O1
RUSKIN, DB2
SCHERGNA, E1
HOUFEK, EE1
HERMANN, HT1
STOUSLAND, H1
BRICK, H1
HOFSTATTER, L1
HUNTER, H1
JENKINS, D1
WITKIND, E1
WAID, ME1
LITTLJOHN, WS1
LITTLE, SC2
McLALLEN, CD1
LUND, M1
NØRGAARD, K1
SCHMUTTERMEIER, E1
STACHEL, I1
BERCEL, NA1
FINESILVER, B1
SOLOMON, P1
SOMERFELD-ZISKIND, E1
ZISKIND, E1
McAVOY, M1
Bohlen, N1
Hertl, M1
Tassinari, CA1
Roger, J1
Maitrot, B1
Hue, G1
Canonne, MA1
Rocher, A1
Landriau, N1
Buchthal, A1
Troupin, AS2
Friel, P1
Lovely, MP1
Wilensky, AJ1
Gerber, N1
Thompson, RM1
Smith, RG1
Lynn, RK1
Yonekawa, W1
Kupferberg, HJ1
Winnacker, JL1
Yeager, H1
Saunders, JA1
Russell, B1
Anast, CS1
Ojemann, LM1
Dodrill, CB1
Nozicková, M1
Danda, J1
Hamáková, K1
Kraus, Z1
Snead, C1
Siegel, N1
Hayslett, J1
Ilyés, I1
Tornai, A1
Kirilina, S1
György, I1

Reviews

1 review available for mephenytoin and Epilepsy

ArticleYear
[Pharmacotherapy of epilepsy. II].
    Die Medizinische Welt, 1978, Jun-02, Volume: 29, Issue:22

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepin

1978

Other Studies

63 other studies available for mephenytoin and Epilepsy

ArticleYear
THE TREATMENT OF EPILEPSY WITH METHYLPHENYLETHYL HYDANTOIN (MESANTOIN).
    California medicine, 1948, Volume: 68, Issue:3

    Topics: Anticonvulsants; Epilepsy; Humans; Hydantoins; Imidazoles; Mephenytoin

1948
The mesantoin; a new anticonvulsant in the fight against epilepsy.
    El Dia medico, 1948, May-03, Volume: 20, Issue:18

    Topics: Epilepsy; Humans; Mephenytoin

1948
Mesantoin in treatment of epilepsy.
    Northwest medicine, 1948, Volume: 47, Issue:7

    Topics: Epilepsy; Mephenytoin

1948
The new anticonvulsant mesantoin, and its place in the treatment of epilepsy.
    The Medical press, 1948, Aug-02, Volume: 220, Issue:5

    Topics: Anticonvulsants; Epilepsy; Mephenytoin

1948
The use of mesantoin in a group of hospitalized psychotic epileptic patients.
    The Medical annals of the District of Columbia, 1948, Volume: 17, Issue:8

    Topics: Epilepsy; Mental Disorders; Mephenytoin; Patients; Psychotic Disorders

1948
Mesantoin in severe epilepsy.
    Quarterly bulletin. Northwestern University (Evanston, Ill.). Medical School, 1948, Volume: 22, Issue:4

    Topics: Epilepsy; Humans; Mephenytoin

1948
Practical aspects of mesantoin therapy in epilepsy.
    The American journal of psychiatry, 1948, Volume: 105, Issue:6

    Topics: Epilepsy; Mephenytoin

1948
Mesantoin, a new anticonvulsant in the management of epilepsy; a preliminary report.
    Rocky Mountain medical journal, 1947, Volume: 44, Issue:8

    Topics: Anticonvulsants; Disease Management; Epilepsy; Humans; Hydantoins; Imidazoles; Mephenytoin

1947
Mesantoin in the treatment of epilepsy; preliminary report.
    The Ohio State medical journal, 1947, Volume: 43, Issue:12

    Topics: Epilepsy; Mephenytoin

1947
Epilepsy; treatment with new drug; 3-methyl 5,5-phenyl-ethyl-hydantoin (phenantoin).
    The American journal of psychiatry, 1946, Volume: 103, Issue:2

    Topics: Anticonvulsants; Epilepsy; Hydantoins; Imidazoles; Mephenytoin

1946
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
    Epilepsia, 2012, Volume: 53 Suppl 8

    Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Human

2012
The control with mesantoin on convulsive seizures due to neurosyphilis; clinical and electroencephalographic studies.
    The Journal of nervous and mental disease, 1952, Volume: 116, Issue:3

    Topics: Electroencephalography; Epilepsy; Humans; Hydantoins; Mephenytoin; Neurosyphilis; Seizures

1952
[Granulocytopenic syndromes in mesantoin therapy].
    Minerva medica, 1952, Oct-01, Volume: 43, Issue:79

    Topics: Agranulocytosis; Epilepsy; Humans; Hydantoins; Mephenytoin; Syndrome

1952
[Complications in mesantoin therapy of epilepsy].
    Svenska lakartidningen, 1953, Feb-27, Volume: 50, Issue:9

    Topics: Epilepsy; Hydantoins; Mephenytoin

1953
[The treatment of epilepsy with mesantoin].
    Munchener medizinische Wochenschrift (1950), 1953, Aug-21, Volume: 95, Issue:34

    Topics: Epilepsy; Hydantoins; Mephenytoin

1953
[Treatment of epilepsy with mesantoin].
    Munchener medizinische Wochenschrift (1950), 1953, Aug-28, Volume: 95, Issue:35

    Topics: Epilepsy; Hydantoins; Mephenytoin

1953
A clinical evaluation of mesantoin in epilepsy.
    The Journal of nervous and mental disease, 1953, Volume: 118, Issue:3

    Topics: Epilepsy; Humans; Hydantoins; Mephenytoin

1953
Mesantoin in the treatment of epilepsy; a study of its effect on the leukocyte count in seventy-nine cases.
    The New England journal of medicine, 1954, Feb-04, Volume: 250, Issue:5

    Topics: Epilepsy; Hydantoins; Leukocyte Count; Mephenytoin

1954
[Mesantoin therapy of epilepsy].
    Ugeskrift for laeger, 1953, Nov-12, Volume: 115, Issue:46

    Topics: Epilepsy; Hydantoins; Mephenytoin

1953
Mesantoin (methyl-phenylethyl-hydantoin) as the anticonvulsant of choice.
    American practitioner and digest of treatment, 1954, Volume: 5, Issue:5

    Topics: Anticonvulsants; Behavior; Choice Behavior; Craniocerebral Trauma; Epilepsy; Hydantoins; Imidazoles;

1954
[Action of 5-ethyl-3-methyl-5-phenylhydantoin on experimental reflex epilepsy].
    Archives internationales de pharmacodynamie et de therapie, 1954, Jun-01, Volume: 98, Issue:2

    Topics: Epilepsy; Epilepsy, Reflex; Hydantoins; Mephenytoin

1954
[Additional experience with mesantoin therapy of epilepsy].
    Der Nervenarzt, 1954, Jun-20, Volume: 25, Issue:6

    Topics: Epilepsy; Hydantoins; Mephenytoin

1954
Mesantoin in the treatment of epilepsy.
    The Psychiatric quarterly, 1955, Volume: 29, Issue:3

    Topics: Epilepsy; Humans; Hydantoins; Mephenytoin

1955
[Mesantoin (sedantoinal) therapy of epilepsy].
    Revista clinica espanola, 1957, Jun-30, Volume: 65, Issue:6

    Topics: Epilepsy; Hydantoins; Mephenytoin

1957
MESANTOIN LYMPHADENOPATHY MORPHOLOGICALLY SIMULATING HODGKIN'S DISEASE.
    Annals of internal medicine, 1963, Volume: 59

    Topics: Drug Hypersensitivity; Epilepsy; Hodgkin Disease; Humans; Hydantoins; Hyperplasia; Hypertrophy; Lymp

1963
[DATA TO THE PROBLEM OF CHRONIC MESANTOIN POISONING].
    Medizinische Klinik, 1964, Jun-05, Volume: 59

    Topics: Adolescent; Blood Transfusion; Electroencephalography; Epilepsy; Epilepsy, Absence; Exanthema; Hydan

1964
Fatal pancytopenia as a result of improperly supervised mesantoin therapy.
    American practitioner and digest of treatment, 1955, Volume: 6, Issue:5

    Topics: Anemia; Anemia, Aplastic; Epilepsy; Hydantoins; Mephenytoin; Pancytopenia; Research Personnel; Trach

1955
[Hydantal and mesantoin in treatment of epilepsy].
    Wiener klinische Wochenschrift, 1950, Aug-25, Volume: 62, Issue:34

    Topics: Epilepsy; Hydantoins; Mephenytoin

1950
Clinical evaluation of mesantoin in treatment of epilepsy.
    A.M.A. archives of neurology and psychiatry, 1951, Volume: 65, Issue:1

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
[Manifestations of intoxication in mesantoin therapy of epilepsy].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1950, Oct-01, Volume: 70, Issue:19

    Topics: Epilepsy; Hydantoins; Mephenytoin

1950
[Differentiation of methylphenylethylhydantoin's (mesantoin's) mode of action in epileptic and in tetanic convulsions].
    Wiener klinische Wochenschrift, 1950, Oct-20, Volume: 62, Issue:42

    Topics: Epilepsy; Humans; Hydantoins; Mephenytoin; Seizures; Tetany

1950
Methoin in the treatment of epilepsy.
    British medical journal, 1951, Jan-13, Volume: 1, Issue:4697

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
[Toxic effects of mesantoin].
    Wiener klinische Wochenschrift, 1950, Dec-22, Volume: 62, Issue:51

    Topics: Epilepsy; Hydantoins; Mephenytoin

1950
[Histological pictures of the swelling of lymphatic nodes occurring in mesantoin therapy].
    Wiener klinische Wochenschrift, 1951, Feb-02, Volume: 63, Issue:5

    Topics: Edema; Epilepsy; Humans; Lymph Nodes; Mephenytoin

1951
[Another case of importance bone-marrow lesion by mesantoin].
    Wiener klinische Wochenschrift, 1951, Feb-16, Volume: 63, Issue:7

    Topics: Bone Marrow; Epilepsy; Hydantoins; Mephenytoin

1951
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
    The American journal of psychiatry, 1950, Volume: 107, Issue:6

    Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures

1950
[New antiepileptic; 3-methyl-5,5-phenylethyl-hydantoin. (mesantoin Sandoz)].
    Rassegna internazionale di clinica e terapia, 1951, Feb-28, Volume: 31, Issue:4

    Topics: Anticonvulsants; Epilepsy; Hydantoins; Imidazoles; Mephenytoin

1951
Mesantoin in difficult cases of epilepsy.
    The Nebraska state medical journal, 1951, Volume: 36, Issue:7

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
[Aplastic anemia caused by the hydantoin derivative mesantoin; fatal case].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1951, Jul-01, Volume: 71, Issue:13-14

    Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Epilepsy; Humans; Hydantoins; Mephenytoin

1951
Treatment of epilepsy with mesantoin or hydantal.
    Virginia medical monthly, 1951, Volume: 78, Issue:8

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
Mesantoin in the management of the hospitalized psychotic epileptic; report of toxic effects and one fatality.
    Southern medical journal, 1951, Volume: 44, Issue:9

    Topics: Disease Management; Epilepsy; Hydantoins; Mental Disorders; Mephenytoin; Psychotic Disorders

1951
Occurrence of skin pigmentation during mesantoin therapy.
    Journal of the American Medical Association, 1951, Oct-20, Volume: 147, Issue:8

    Topics: Epilepsy; Hydantoins; Mephenytoin; Skin; Skin Pigmentation

1951
Aplasia of the bone marrow during mesantoin therapy; report of a fatal case.
    Journal of the American Medical Association, 1951, Oct-20, Volume: 147, Issue:8

    Topics: Bone Marrow; Epilepsy; Hydantoins; Mephenytoin

1951
Mesantoin in the treatment of convulsive disorders.
    Diseases of the nervous system, 1951, Volume: 12, Issue:9

    Topics: Epilepsy; Hydantoins; Mephenytoin; Seizures

1951
Treatment of epilepsy with mesantoin and phenantoin.
    Acta psychiatrica et neurologica Scandinavica. Supplementum, 1951, Volume: 74

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
[Results of mesantoin therapy of epilepsy].
    Medizinische Monatsschrift, 1951, Volume: 5, Issue:11

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
[Experiences with hydantal Sandoz and Mesantoin in the therapy of epilepsy of children].
    Osterreichische Zeitschrift fur Kinderheilkunde und Kinderfursorge, 1952, Volume: 7, Issue:1-2

    Topics: Child; Epilepsy; Hydantoins; Infant; Mephenytoin

1952
Mesantoin in epilepsy; a 3 year study.
    Diseases of the nervous system, 1949, Volume: 10, Issue:12

    Topics: Epilepsy; Humans; Mephenytoin

1949
Mesantoin in treatment of epilepsy; a report on 200 patients under treatment for periods raging from 2 months to 4 years.
    Archives of neurology and psychiatry, 1950, Volume: 63, Issue:2

    Topics: Epilepsy; Humans; Mephenytoin

1950
Mesantoin in epilepsy; report of 80 cases.
    Journal of the American Medical Association, 1950, Aug-26, Volume: 143, Issue:17

    Topics: Epilepsy; Hydantoins; Mephenytoin

1950
Mesantoin in treatment of epilepsy in a state hospital.
    Archives of neurology and psychiatry, 1948, Volume: 60, Issue:5

    Topics: Epilepsy; Hospitals, State; Mephenytoin

1948
Changes in the electroencephalogram following administration o mesantoin (methyl-phenyl-ethyl hydantoin).
    Electroencephalography and clinical neurophysiology, 1949, Volume: 1, Issue:3

    Topics: Anticonvulsants; Electroencephalography; Epilepsy; Hydantoins; Mephenytoin

1949
[Adverse effects of anti-epileptic drugs].
    Deutsche medizinische Wochenschrift (1946), 1975, Sep-19, Volume: 100, Issue:38

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos

1975
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
    Advances in neurology, 1975, Volume: 11

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Tempo

1975
[Determination of phenobarbital, mephenytoin and diphenylhydantoin in the surveillance of anticonvulsant treatment].
    Annales de biologie clinique, 1976, Volume: 34, Issue:2

    Topics: Barbiturates; Child; Chromatography, Gas; Epilepsy; Ether; Humans; Hydantoins; Mephenytoin; Methylat

1976
Clinical pharmacology of mephenytoin and ethotoin.
    Annals of neurology, 1979, Volume: 6, Issue:5

    Topics: Biotransformation; Epilepsy; Half-Life; Humans; Hydantoins; Kinetics; Mephenytoin; Saliva; Time Fact

1979
Evidence for the epoxide-diol pathway in the biotransformation of mephenytoin.
    Epilepsia, 1979, Volume: 20, Issue:3

    Topics: Adult; Biotransformation; Epilepsy; Humans; Hydantoins; Male; Mephenytoin

1979
Measurement of mephenytoin (3-methyl-5-ethyl-5-phenylhydantoin) and its demethylated metabolite by selective ion monitoring.
    Journal of chromatography, 1979, Jun-11, Volume: 163, Issue:2

    Topics: Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Hydantoins; Mephenytoin; Time Factors

1979
Rickets in children receiving anticonvulsant drugs. Biochemical and hormonal markers.
    American journal of diseases of children (1960), 1977, Volume: 131, Issue:3

    Topics: Adolescent; Anticonvulsants; Calcium; Child; Child, Preschool; Drug Combinations; Epilepsy; Evaluati

1977
Mephenytoin: a reappraisal.
    Epilepsia, 1976, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Anemia, Aplastic; Anticonvulsants; Chemical Phenomena; Chemistry; Drug Evaluation

1976
[Toxic epidermal necrolosys -- Lyell's syndrome in a patient protractedly treated by anti-epileptic agents].
    Ceskoslovenska dermatologie, 1976, Volume: 51, Issue:6

    Topics: Adult; Anticonvulsants; Barbiturates; Epilepsy; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin;

1976
Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity.
    Pediatrics, 1976, Volume: 57, Issue:1

    Topics: Adolescent; Edema; Epilepsy; Humans; Hydantoins; Lymphatic Diseases; Male; Mephenytoin; Nephrotic Sy

1976
Influence of anticonvulsant drugs on thyroid hormones in epileptic children.
    Acta paediatrica Hungarica, 1985, Volume: 26, Issue:4

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Mephenytoin; Phenytoin; Primidone; Thyro

1985