mephenytoin has been researched along with Epilepsy in 64 studies
Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Excerpt | Relevance | Reference |
---|---|---|
"This report describes a patient who developed marked generalized adenopathy and nephrotic syndrome while receiving mephenytoin (mesantoin) for a seizure disorder." | 7.65 | Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity. ( Hayslett, J; Siegel, N; Snead, C, 1976) |
"This report describes a patient who developed marked generalized adenopathy and nephrotic syndrome while receiving mephenytoin (mesantoin) for a seizure disorder." | 3.65 | Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity. ( Hayslett, J; Siegel, N; Snead, C, 1976) |
"Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912." | 1.38 | How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)? ( Bialer, M, 2012) |
"Mean mephenytoin level was 8% of the combined mephenytoin plus nirvanol levels." | 1.26 | Mephenytoin: a reappraisal. ( Dodrill, CB; Ojemann, LM; Troupin, AS, 1976) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 63 (98.44) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (1.56) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Aird, RB | 1 |
MOSOVICH, A | 1 |
RICKLES, NK | 1 |
PULLAR-STRECKER, H | 1 |
MYERS, HJ | 1 |
ARIEFF, AJ | 1 |
FETTERMAN, JL | 3 |
VICTOROFF, VM | 2 |
CARTER, HR | 1 |
FRIEDMAN, MD | 1 |
KOZOL, HL | 2 |
Bialer, M | 1 |
WONG, YT | 1 |
HAYS, AL | 1 |
HILL, TS | 1 |
BELSASSO, M | 1 |
BONIVENTO, M | 1 |
ANDERSSON, B | 1 |
HALLEN, O | 2 |
MALLIN, AW | 2 |
GAMMON, GD | 2 |
ABBOTT, JA | 1 |
SCHWAB, RS | 1 |
FUGLSANG-FREDERIKSEN, V | 1 |
BARO, WZ | 1 |
LA GRUTTA, G | 1 |
KLOPP, HW | 2 |
WISE, RA | 1 |
HEUMANN, WA | 1 |
GONZALEZ GUIJA, A | 1 |
DOYLE, AP | 1 |
HELLSTROM, HR | 1 |
GRIESSHABER, W | 1 |
BURRELL, ZL | 1 |
SOLMS, W | 1 |
WALLENTIN, G | 1 |
GABRIELSEN, LH | 1 |
JESSERER, H | 1 |
JONES, DP | 1 |
HOLUB, K | 1 |
WILD, H | 1 |
CHIARI, H | 1 |
WEINMANN, O | 1 |
RUSKIN, DB | 2 |
SCHERGNA, E | 1 |
HOUFEK, EE | 1 |
HERMANN, HT | 1 |
STOUSLAND, H | 1 |
BRICK, H | 1 |
HOFSTATTER, L | 1 |
HUNTER, H | 1 |
JENKINS, D | 1 |
WITKIND, E | 1 |
WAID, ME | 1 |
LITTLJOHN, WS | 1 |
LITTLE, SC | 2 |
McLALLEN, CD | 1 |
LUND, M | 1 |
NØRGAARD, K | 1 |
SCHMUTTERMEIER, E | 1 |
STACHEL, I | 1 |
BERCEL, NA | 1 |
FINESILVER, B | 1 |
SOLOMON, P | 1 |
SOMERFELD-ZISKIND, E | 1 |
ZISKIND, E | 1 |
McAVOY, M | 1 |
Bohlen, N | 1 |
Hertl, M | 1 |
Tassinari, CA | 1 |
Roger, J | 1 |
Maitrot, B | 1 |
Hue, G | 1 |
Canonne, MA | 1 |
Rocher, A | 1 |
Landriau, N | 1 |
Buchthal, A | 1 |
Troupin, AS | 2 |
Friel, P | 1 |
Lovely, MP | 1 |
Wilensky, AJ | 1 |
Gerber, N | 1 |
Thompson, RM | 1 |
Smith, RG | 1 |
Lynn, RK | 1 |
Yonekawa, W | 1 |
Kupferberg, HJ | 1 |
Winnacker, JL | 1 |
Yeager, H | 1 |
Saunders, JA | 1 |
Russell, B | 1 |
Anast, CS | 1 |
Ojemann, LM | 1 |
Dodrill, CB | 1 |
Nozicková, M | 1 |
Danda, J | 1 |
Hamáková, K | 1 |
Kraus, Z | 1 |
Snead, C | 1 |
Siegel, N | 1 |
Hayslett, J | 1 |
Ilyés, I | 1 |
Tornai, A | 1 |
Kirilina, S | 1 |
György, I | 1 |
1 review available for mephenytoin and Epilepsy
Article | Year |
---|---|
[Pharmacotherapy of epilepsy. II].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepin | 1978 |
63 other studies available for mephenytoin and Epilepsy
Article | Year |
---|---|
THE TREATMENT OF EPILEPSY WITH METHYLPHENYLETHYL HYDANTOIN (MESANTOIN).
Topics: Anticonvulsants; Epilepsy; Humans; Hydantoins; Imidazoles; Mephenytoin | 1948 |
The mesantoin; a new anticonvulsant in the fight against epilepsy.
Topics: Epilepsy; Humans; Mephenytoin | 1948 |
Mesantoin in treatment of epilepsy.
Topics: Epilepsy; Mephenytoin | 1948 |
The new anticonvulsant mesantoin, and its place in the treatment of epilepsy.
Topics: Anticonvulsants; Epilepsy; Mephenytoin | 1948 |
The use of mesantoin in a group of hospitalized psychotic epileptic patients.
Topics: Epilepsy; Mental Disorders; Mephenytoin; Patients; Psychotic Disorders | 1948 |
Mesantoin in severe epilepsy.
Topics: Epilepsy; Humans; Mephenytoin | 1948 |
Practical aspects of mesantoin therapy in epilepsy.
Topics: Epilepsy; Mephenytoin | 1948 |
Mesantoin, a new anticonvulsant in the management of epilepsy; a preliminary report.
Topics: Anticonvulsants; Disease Management; Epilepsy; Humans; Hydantoins; Imidazoles; Mephenytoin | 1947 |
Mesantoin in the treatment of epilepsy; preliminary report.
Topics: Epilepsy; Mephenytoin | 1947 |
Epilepsy; treatment with new drug; 3-methyl 5,5-phenyl-ethyl-hydantoin (phenantoin).
Topics: Anticonvulsants; Epilepsy; Hydantoins; Imidazoles; Mephenytoin | 1946 |
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Human | 2012 |
The control with mesantoin on convulsive seizures due to neurosyphilis; clinical and electroencephalographic studies.
Topics: Electroencephalography; Epilepsy; Humans; Hydantoins; Mephenytoin; Neurosyphilis; Seizures | 1952 |
[Granulocytopenic syndromes in mesantoin therapy].
Topics: Agranulocytosis; Epilepsy; Humans; Hydantoins; Mephenytoin; Syndrome | 1952 |
[Complications in mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
[The treatment of epilepsy with mesantoin].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
[Treatment of epilepsy with mesantoin].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
A clinical evaluation of mesantoin in epilepsy.
Topics: Epilepsy; Humans; Hydantoins; Mephenytoin | 1953 |
Mesantoin in the treatment of epilepsy; a study of its effect on the leukocyte count in seventy-nine cases.
Topics: Epilepsy; Hydantoins; Leukocyte Count; Mephenytoin | 1954 |
[Mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
Mesantoin (methyl-phenylethyl-hydantoin) as the anticonvulsant of choice.
Topics: Anticonvulsants; Behavior; Choice Behavior; Craniocerebral Trauma; Epilepsy; Hydantoins; Imidazoles; | 1954 |
[Action of 5-ethyl-3-methyl-5-phenylhydantoin on experimental reflex epilepsy].
Topics: Epilepsy; Epilepsy, Reflex; Hydantoins; Mephenytoin | 1954 |
[Additional experience with mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1954 |
Mesantoin in the treatment of epilepsy.
Topics: Epilepsy; Humans; Hydantoins; Mephenytoin | 1955 |
[Mesantoin (sedantoinal) therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1957 |
MESANTOIN LYMPHADENOPATHY MORPHOLOGICALLY SIMULATING HODGKIN'S DISEASE.
Topics: Drug Hypersensitivity; Epilepsy; Hodgkin Disease; Humans; Hydantoins; Hyperplasia; Hypertrophy; Lymp | 1963 |
[DATA TO THE PROBLEM OF CHRONIC MESANTOIN POISONING].
Topics: Adolescent; Blood Transfusion; Electroencephalography; Epilepsy; Epilepsy, Absence; Exanthema; Hydan | 1964 |
Fatal pancytopenia as a result of improperly supervised mesantoin therapy.
Topics: Anemia; Anemia, Aplastic; Epilepsy; Hydantoins; Mephenytoin; Pancytopenia; Research Personnel; Trach | 1955 |
[Hydantal and mesantoin in treatment of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
Clinical evaluation of mesantoin in treatment of epilepsy.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Manifestations of intoxication in mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
[Differentiation of methylphenylethylhydantoin's (mesantoin's) mode of action in epileptic and in tetanic convulsions].
Topics: Epilepsy; Humans; Hydantoins; Mephenytoin; Seizures; Tetany | 1950 |
Methoin in the treatment of epilepsy.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Toxic effects of mesantoin].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
[Histological pictures of the swelling of lymphatic nodes occurring in mesantoin therapy].
Topics: Edema; Epilepsy; Humans; Lymph Nodes; Mephenytoin | 1951 |
[Another case of importance bone-marrow lesion by mesantoin].
Topics: Bone Marrow; Epilepsy; Hydantoins; Mephenytoin | 1951 |
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures | 1950 |
[New antiepileptic; 3-methyl-5,5-phenylethyl-hydantoin. (mesantoin Sandoz)].
Topics: Anticonvulsants; Epilepsy; Hydantoins; Imidazoles; Mephenytoin | 1951 |
Mesantoin in difficult cases of epilepsy.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Aplastic anemia caused by the hydantoin derivative mesantoin; fatal case].
Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Epilepsy; Humans; Hydantoins; Mephenytoin | 1951 |
Treatment of epilepsy with mesantoin or hydantal.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
Mesantoin in the management of the hospitalized psychotic epileptic; report of toxic effects and one fatality.
Topics: Disease Management; Epilepsy; Hydantoins; Mental Disorders; Mephenytoin; Psychotic Disorders | 1951 |
Occurrence of skin pigmentation during mesantoin therapy.
Topics: Epilepsy; Hydantoins; Mephenytoin; Skin; Skin Pigmentation | 1951 |
Aplasia of the bone marrow during mesantoin therapy; report of a fatal case.
Topics: Bone Marrow; Epilepsy; Hydantoins; Mephenytoin | 1951 |
Mesantoin in the treatment of convulsive disorders.
Topics: Epilepsy; Hydantoins; Mephenytoin; Seizures | 1951 |
Treatment of epilepsy with mesantoin and phenantoin.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Results of mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Experiences with hydantal Sandoz and Mesantoin in the therapy of epilepsy of children].
Topics: Child; Epilepsy; Hydantoins; Infant; Mephenytoin | 1952 |
Mesantoin in epilepsy; a 3 year study.
Topics: Epilepsy; Humans; Mephenytoin | 1949 |
Mesantoin in treatment of epilepsy; a report on 200 patients under treatment for periods raging from 2 months to 4 years.
Topics: Epilepsy; Humans; Mephenytoin | 1950 |
Mesantoin in epilepsy; report of 80 cases.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
Mesantoin in treatment of epilepsy in a state hospital.
Topics: Epilepsy; Hospitals, State; Mephenytoin | 1948 |
Changes in the electroencephalogram following administration o mesantoin (methyl-phenyl-ethyl hydantoin).
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Hydantoins; Mephenytoin | 1949 |
[Adverse effects of anti-epileptic drugs].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos | 1975 |
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Tempo | 1975 |
[Determination of phenobarbital, mephenytoin and diphenylhydantoin in the surveillance of anticonvulsant treatment].
Topics: Barbiturates; Child; Chromatography, Gas; Epilepsy; Ether; Humans; Hydantoins; Mephenytoin; Methylat | 1976 |
Clinical pharmacology of mephenytoin and ethotoin.
Topics: Biotransformation; Epilepsy; Half-Life; Humans; Hydantoins; Kinetics; Mephenytoin; Saliva; Time Fact | 1979 |
Evidence for the epoxide-diol pathway in the biotransformation of mephenytoin.
Topics: Adult; Biotransformation; Epilepsy; Humans; Hydantoins; Male; Mephenytoin | 1979 |
Measurement of mephenytoin (3-methyl-5-ethyl-5-phenylhydantoin) and its demethylated metabolite by selective ion monitoring.
Topics: Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Hydantoins; Mephenytoin; Time Factors | 1979 |
Rickets in children receiving anticonvulsant drugs. Biochemical and hormonal markers.
Topics: Adolescent; Anticonvulsants; Calcium; Child; Child, Preschool; Drug Combinations; Epilepsy; Evaluati | 1977 |
Mephenytoin: a reappraisal.
Topics: Adolescent; Adult; Anemia, Aplastic; Anticonvulsants; Chemical Phenomena; Chemistry; Drug Evaluation | 1976 |
[Toxic epidermal necrolosys -- Lyell's syndrome in a patient protractedly treated by anti-epileptic agents].
Topics: Adult; Anticonvulsants; Barbiturates; Epilepsy; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin; | 1976 |
Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity.
Topics: Adolescent; Edema; Epilepsy; Humans; Hydantoins; Lymphatic Diseases; Male; Mephenytoin; Nephrotic Sy | 1976 |
Influence of anticonvulsant drugs on thyroid hormones in epileptic children.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Mephenytoin; Phenytoin; Primidone; Thyro | 1985 |