mephenytoin and Aura
mephenytoin has been researched along with Aura in 64 studies
Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This report describes a patient who developed marked generalized adenopathy and nephrotic syndrome while receiving mephenytoin (mesantoin) for a seizure disorder." | 7.65 | Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity. ( Hayslett, J; Siegel, N; Snead, C, 1976) |
| "This report describes a patient who developed marked generalized adenopathy and nephrotic syndrome while receiving mephenytoin (mesantoin) for a seizure disorder." | 3.65 | Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity. ( Hayslett, J; Siegel, N; Snead, C, 1976) |
| "Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912." | 1.38 | How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)? ( Bialer, M, 2012) |
| "Mean mephenytoin level was 8% of the combined mephenytoin plus nirvanol levels." | 1.26 | Mephenytoin: a reappraisal. ( Dodrill, CB; Ojemann, LM; Troupin, AS, 1976) |
Research
Studies (64)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 63 (98.44) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (1.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Aird, RB | 1 |
| MOSOVICH, A | 1 |
| RICKLES, NK | 1 |
| PULLAR-STRECKER, H | 1 |
| MYERS, HJ | 1 |
| ARIEFF, AJ | 1 |
| FETTERMAN, JL | 3 |
| VICTOROFF, VM | 2 |
| CARTER, HR | 1 |
| FRIEDMAN, MD | 1 |
| KOZOL, HL | 2 |
| Bialer, M | 1 |
| WONG, YT | 1 |
| HAYS, AL | 1 |
| HILL, TS | 1 |
| BELSASSO, M | 1 |
| BONIVENTO, M | 1 |
| ANDERSSON, B | 1 |
| HALLEN, O | 2 |
| MALLIN, AW | 2 |
| GAMMON, GD | 2 |
| ABBOTT, JA | 1 |
| SCHWAB, RS | 1 |
| FUGLSANG-FREDERIKSEN, V | 1 |
| BARO, WZ | 1 |
| LA GRUTTA, G | 1 |
| KLOPP, HW | 2 |
| WISE, RA | 1 |
| HEUMANN, WA | 1 |
| GONZALEZ GUIJA, A | 1 |
| DOYLE, AP | 1 |
| HELLSTROM, HR | 1 |
| GRIESSHABER, W | 1 |
| BURRELL, ZL | 1 |
| SOLMS, W | 1 |
| WALLENTIN, G | 1 |
| GABRIELSEN, LH | 1 |
| JESSERER, H | 1 |
| JONES, DP | 1 |
| HOLUB, K | 1 |
| WILD, H | 1 |
| CHIARI, H | 1 |
| WEINMANN, O | 1 |
| RUSKIN, DB | 2 |
| SCHERGNA, E | 1 |
| HOUFEK, EE | 1 |
| HERMANN, HT | 1 |
| STOUSLAND, H | 1 |
| BRICK, H | 1 |
| HOFSTATTER, L | 1 |
| HUNTER, H | 1 |
| JENKINS, D | 1 |
| WITKIND, E | 1 |
| WAID, ME | 1 |
| LITTLJOHN, WS | 1 |
| LITTLE, SC | 2 |
| McLALLEN, CD | 1 |
| LUND, M | 1 |
| NØRGAARD, K | 1 |
| SCHMUTTERMEIER, E | 1 |
| STACHEL, I | 1 |
| BERCEL, NA | 1 |
| FINESILVER, B | 1 |
| SOLOMON, P | 1 |
| SOMERFELD-ZISKIND, E | 1 |
| ZISKIND, E | 1 |
| McAVOY, M | 1 |
| Bohlen, N | 1 |
| Hertl, M | 1 |
| Tassinari, CA | 1 |
| Roger, J | 1 |
| Maitrot, B | 1 |
| Hue, G | 1 |
| Canonne, MA | 1 |
| Rocher, A | 1 |
| Landriau, N | 1 |
| Buchthal, A | 1 |
| Troupin, AS | 2 |
| Friel, P | 1 |
| Lovely, MP | 1 |
| Wilensky, AJ | 1 |
| Gerber, N | 1 |
| Thompson, RM | 1 |
| Smith, RG | 1 |
| Lynn, RK | 1 |
| Yonekawa, W | 1 |
| Kupferberg, HJ | 1 |
| Winnacker, JL | 1 |
| Yeager, H | 1 |
| Saunders, JA | 1 |
| Russell, B | 1 |
| Anast, CS | 1 |
| Ojemann, LM | 1 |
| Dodrill, CB | 1 |
| Nozicková, M | 1 |
| Danda, J | 1 |
| Hamáková, K | 1 |
| Kraus, Z | 1 |
| Snead, C | 1 |
| Siegel, N | 1 |
| Hayslett, J | 1 |
| Ilyés, I | 1 |
| Tornai, A | 1 |
| Kirilina, S | 1 |
| György, I | 1 |
Reviews
1 review available for mephenytoin and Aura
| Article | Year |
|---|---|
[Pharmacotherapy of epilepsy. II].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepin | 1978 |
Other Studies
63 other studies available for mephenytoin and Aura
| Article | Year |
|---|---|
THE TREATMENT OF EPILEPSY WITH METHYLPHENYLETHYL HYDANTOIN (MESANTOIN).
Topics: Anticonvulsants; Epilepsy; Humans; Hydantoins; Imidazoles; Mephenytoin | 1948 |
The mesantoin; a new anticonvulsant in the fight against epilepsy.
Topics: Epilepsy; Humans; Mephenytoin | 1948 |
Mesantoin in treatment of epilepsy.
Topics: Epilepsy; Mephenytoin | 1948 |
The new anticonvulsant mesantoin, and its place in the treatment of epilepsy.
Topics: Anticonvulsants; Epilepsy; Mephenytoin | 1948 |
The use of mesantoin in a group of hospitalized psychotic epileptic patients.
Topics: Epilepsy; Mental Disorders; Mephenytoin; Patients; Psychotic Disorders | 1948 |
Mesantoin in severe epilepsy.
Topics: Epilepsy; Humans; Mephenytoin | 1948 |
Practical aspects of mesantoin therapy in epilepsy.
Topics: Epilepsy; Mephenytoin | 1948 |
Mesantoin, a new anticonvulsant in the management of epilepsy; a preliminary report.
Topics: Anticonvulsants; Disease Management; Epilepsy; Humans; Hydantoins; Imidazoles; Mephenytoin | 1947 |
Mesantoin in the treatment of epilepsy; preliminary report.
Topics: Epilepsy; Mephenytoin | 1947 |
Epilepsy; treatment with new drug; 3-methyl 5,5-phenyl-ethyl-hydantoin (phenantoin).
Topics: Anticonvulsants; Epilepsy; Hydantoins; Imidazoles; Mephenytoin | 1946 |
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Human | 2012 |
The control with mesantoin on convulsive seizures due to neurosyphilis; clinical and electroencephalographic studies.
Topics: Electroencephalography; Epilepsy; Humans; Hydantoins; Mephenytoin; Neurosyphilis; Seizures | 1952 |
[Granulocytopenic syndromes in mesantoin therapy].
Topics: Agranulocytosis; Epilepsy; Humans; Hydantoins; Mephenytoin; Syndrome | 1952 |
[Complications in mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
[The treatment of epilepsy with mesantoin].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
[Treatment of epilepsy with mesantoin].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
A clinical evaluation of mesantoin in epilepsy.
Topics: Epilepsy; Humans; Hydantoins; Mephenytoin | 1953 |
Mesantoin in the treatment of epilepsy; a study of its effect on the leukocyte count in seventy-nine cases.
Topics: Epilepsy; Hydantoins; Leukocyte Count; Mephenytoin | 1954 |
[Mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
Mesantoin (methyl-phenylethyl-hydantoin) as the anticonvulsant of choice.
Topics: Anticonvulsants; Behavior; Choice Behavior; Craniocerebral Trauma; Epilepsy; Hydantoins; Imidazoles; | 1954 |
[Action of 5-ethyl-3-methyl-5-phenylhydantoin on experimental reflex epilepsy].
Topics: Epilepsy; Epilepsy, Reflex; Hydantoins; Mephenytoin | 1954 |
[Additional experience with mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1954 |
Mesantoin in the treatment of epilepsy.
Topics: Epilepsy; Humans; Hydantoins; Mephenytoin | 1955 |
[Mesantoin (sedantoinal) therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1957 |
MESANTOIN LYMPHADENOPATHY MORPHOLOGICALLY SIMULATING HODGKIN'S DISEASE.
Topics: Drug Hypersensitivity; Epilepsy; Hodgkin Disease; Humans; Hydantoins; Hyperplasia; Hypertrophy; Lymp | 1963 |
[DATA TO THE PROBLEM OF CHRONIC MESANTOIN POISONING].
Topics: Adolescent; Blood Transfusion; Electroencephalography; Epilepsy; Epilepsy, Absence; Exanthema; Hydan | 1964 |
Fatal pancytopenia as a result of improperly supervised mesantoin therapy.
Topics: Anemia; Anemia, Aplastic; Epilepsy; Hydantoins; Mephenytoin; Pancytopenia; Research Personnel; Trach | 1955 |
[Hydantal and mesantoin in treatment of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
Clinical evaluation of mesantoin in treatment of epilepsy.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Manifestations of intoxication in mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
[Differentiation of methylphenylethylhydantoin's (mesantoin's) mode of action in epileptic and in tetanic convulsions].
Topics: Epilepsy; Humans; Hydantoins; Mephenytoin; Seizures; Tetany | 1950 |
Methoin in the treatment of epilepsy.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Toxic effects of mesantoin].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
[Histological pictures of the swelling of lymphatic nodes occurring in mesantoin therapy].
Topics: Edema; Epilepsy; Humans; Lymph Nodes; Mephenytoin | 1951 |
[Another case of importance bone-marrow lesion by mesantoin].
Topics: Bone Marrow; Epilepsy; Hydantoins; Mephenytoin | 1951 |
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures | 1950 |
[New antiepileptic; 3-methyl-5,5-phenylethyl-hydantoin. (mesantoin Sandoz)].
Topics: Anticonvulsants; Epilepsy; Hydantoins; Imidazoles; Mephenytoin | 1951 |
Mesantoin in difficult cases of epilepsy.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Aplastic anemia caused by the hydantoin derivative mesantoin; fatal case].
Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Epilepsy; Humans; Hydantoins; Mephenytoin | 1951 |
Treatment of epilepsy with mesantoin or hydantal.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
Mesantoin in the management of the hospitalized psychotic epileptic; report of toxic effects and one fatality.
Topics: Disease Management; Epilepsy; Hydantoins; Mental Disorders; Mephenytoin; Psychotic Disorders | 1951 |
Occurrence of skin pigmentation during mesantoin therapy.
Topics: Epilepsy; Hydantoins; Mephenytoin; Skin; Skin Pigmentation | 1951 |
Aplasia of the bone marrow during mesantoin therapy; report of a fatal case.
Topics: Bone Marrow; Epilepsy; Hydantoins; Mephenytoin | 1951 |
Mesantoin in the treatment of convulsive disorders.
Topics: Epilepsy; Hydantoins; Mephenytoin; Seizures | 1951 |
Treatment of epilepsy with mesantoin and phenantoin.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Results of mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Experiences with hydantal Sandoz and Mesantoin in the therapy of epilepsy of children].
Topics: Child; Epilepsy; Hydantoins; Infant; Mephenytoin | 1952 |
Mesantoin in epilepsy; a 3 year study.
Topics: Epilepsy; Humans; Mephenytoin | 1949 |
Mesantoin in treatment of epilepsy; a report on 200 patients under treatment for periods raging from 2 months to 4 years.
Topics: Epilepsy; Humans; Mephenytoin | 1950 |
Mesantoin in epilepsy; report of 80 cases.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
Mesantoin in treatment of epilepsy in a state hospital.
Topics: Epilepsy; Hospitals, State; Mephenytoin | 1948 |
Changes in the electroencephalogram following administration o mesantoin (methyl-phenyl-ethyl hydantoin).
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Hydantoins; Mephenytoin | 1949 |
[Adverse effects of anti-epileptic drugs].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos | 1975 |
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Tempo | 1975 |
[Determination of phenobarbital, mephenytoin and diphenylhydantoin in the surveillance of anticonvulsant treatment].
Topics: Barbiturates; Child; Chromatography, Gas; Epilepsy; Ether; Humans; Hydantoins; Mephenytoin; Methylat | 1976 |
Clinical pharmacology of mephenytoin and ethotoin.
Topics: Biotransformation; Epilepsy; Half-Life; Humans; Hydantoins; Kinetics; Mephenytoin; Saliva; Time Fact | 1979 |
Evidence for the epoxide-diol pathway in the biotransformation of mephenytoin.
Topics: Adult; Biotransformation; Epilepsy; Humans; Hydantoins; Male; Mephenytoin | 1979 |
Measurement of mephenytoin (3-methyl-5-ethyl-5-phenylhydantoin) and its demethylated metabolite by selective ion monitoring.
Topics: Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Hydantoins; Mephenytoin; Time Factors | 1979 |
Rickets in children receiving anticonvulsant drugs. Biochemical and hormonal markers.
Topics: Adolescent; Anticonvulsants; Calcium; Child; Child, Preschool; Drug Combinations; Epilepsy; Evaluati | 1977 |
Mephenytoin: a reappraisal.
Topics: Adolescent; Adult; Anemia, Aplastic; Anticonvulsants; Chemical Phenomena; Chemistry; Drug Evaluation | 1976 |
[Toxic epidermal necrolosys -- Lyell's syndrome in a patient protractedly treated by anti-epileptic agents].
Topics: Adult; Anticonvulsants; Barbiturates; Epilepsy; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin; | 1976 |
Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity.
Topics: Adolescent; Edema; Epilepsy; Humans; Hydantoins; Lymphatic Diseases; Male; Mephenytoin; Nephrotic Sy | 1976 |
Influence of anticonvulsant drugs on thyroid hormones in epileptic children.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Mephenytoin; Phenytoin; Primidone; Thyro | 1985 |