Compounds > mephenytoin
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mephenytoin and Anemia, Aplastic

mephenytoin has been researched along with Anemia, Aplastic in 15 studies

Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.

Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.

Research Excerpts

ExcerptRelevanceReference
"Mean mephenytoin level was 8% of the combined mephenytoin plus nirvanol levels."1.26Mephenytoin: a reappraisal. ( Dodrill, CB; Ojemann, LM; Troupin, AS, 1976)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-199015 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
BLOOM, N1
LYNCH, JP1
BRICK, H1
NIELSEN, DI1
SWARTOUT, R1
SPRING, M1
SOLTZ, WB1
WILLIAMS, CM1
BURRELL, ZL1
WEISS, HA1
HAWLEY, WD1
STILLMAN, S1
BEDELL, SG1
LEAVITT, D1
STOUSLAND, H1
WEINMANN, O1
FRANK, CW1
HOLLAND, JF1
FORSTER, FM1
FRANKEL, K1
ENGLAND, NJ1
McEACHERN, D1
WELLER, RW1
METCALFE, J1
Troupin, AS1
Ojemann, LM1
Dodrill, CB1

Other Studies

15 other studies available for mephenytoin and Anemia, Aplastic

ArticleYear
Mesantoin poisoning with aplastic anemia and recovery.
    Journal of the American Medical Association, 1948, Oct-16, Volume: 138, Issue:7

    Topics: Anemia, Aplastic; Biological Phenomena; Mephenytoin; Physiological Phenomena

1948
Aplastic anemia following mesantoin with recovery, case report.
    Annals of western medicine and surgery, 1952, Volume: 6, Issue:9

    Topics: Anemia; Anemia, Aplastic; Biological Phenomena; Hydantoins; Mephenytoin; Physiological Phenomena

1952
Two cases of fatal pancytopenia following mesantoin therapy.
    California medicine, 1953, Volume: 78, Issue:2

    Topics: Anemia; Anemia, Aplastic; Hydantoins; Mephenytoin; Pancytopenia; Tracheophyta

1953
Fatal aplastic anemia due to methylphenylethyl hydantoin (mesantoin).
    New York state journal of medicine, 1955, Dec-01, Volume: 55, Issue:23

    Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Humans; Hydantoins; Imidazoles; Mephenytoin

1955
Aplastic anaemia due to 3-methyl-5-phenyl-5-ethyl-hydantoin ("mesantoin").
    Clinical reports, 1960, Volume: 10

    Topics: Anemia; Anemia, Aplastic; Humans; Hydantoins; Mephenytoin

1960
Fatal pancytopenia as a result of improperly supervised mesantoin therapy.
    American practitioner and digest of treatment, 1955, Volume: 6, Issue:5

    Topics: Anemia; Anemia, Aplastic; Epilepsy; Hydantoins; Mephenytoin; Pancytopenia; Research Personnel; Trach

1955
Pancytopenia following the use of mesantoin and thiantoin. Report of a fatal case.
    United States Armed Forces medical journal, 1951, Volume: 2, Issue:1

    Topics: Anemia; Anemia, Aplastic; Humans; Hydantoins; Mephenytoin; Pancytopenia; Tracheophyta

1951
Fatal aplastic anemia associated with mesantoin; report of a case with autopsy.
    The Journal of the Florida Medical Association. Florida Medical Association, 1951, Volume: 37, Issue:8

    Topics: Anemia; Anemia, Aplastic; Autopsy; Humans; Hydantoins; Mephenytoin; Tracheophyta

1951
[Aplastic anemia caused by the hydantoin derivative mesantoin; fatal case].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1951, Jul-01, Volume: 71, Issue:13-14

    Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Epilepsy; Humans; Hydantoins; Mephenytoin

1951
[Another case of aplastic anemia due to mesantoin].
    Wiener klinische Wochenschrift, 1951, Aug-17, Volume: 63, Issue:33

    Topics: Anemia; Anemia, Aplastic; Hydantoins; Mephenytoin

1951
Pancytopenia from mesantoin; report of two cases.
    Journal of the American Medical Association, 1948, Dec-18, Volume: 138, Issue:16

    Topics: Anemia, Aplastic; Humans; Mephenytoin; Pancytopenia

1948
Fatal aplastic anemia during anti-convulsant therapy; report of a case during phenurone therapy and following mesantoin therapy.
    Diseases of the nervous system, 1949, Volume: 10, Issue:4

    Topics: Anemia, Aplastic; Benzeneacetamides; Convulsants; Mephenytoin; Urea

1949
Acute aplastic anaemia during mesantoin therapy.
    Canadian Medical Association journal, 1949, Volume: 60, Issue:2

    Topics: Anemia; Anemia, Aplastic; Humans; Mephenytoin

1949
Fatal pancytopenia following the use of mesantoin; report of a case.
    The New England journal of medicine, 1949, Jul-07, Volume: 241, Issue:1

    Topics: Aged; Anemia, Aplastic; Humans; Hydantoins; Mephenytoin; Pancytopenia

1949
Mephenytoin: a reappraisal.
    Epilepsia, 1976, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Anemia, Aplastic; Anticonvulsants; Chemical Phenomena; Chemistry; Drug Evaluation

1976