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mephenytoin and Aging

mephenytoin has been researched along with Aging in 2 studies

Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"To examine whether a drug-metabolizing enzyme changes with normal aging, the S:R index of S-mephenytoin 4-hydroxylation was determined in 150, unmedicated elderly Americans (mean age 75."3.68S-mephenytoin 4-hydroxylation in older Americans. ( Altieri, LP; Kirshner, M; Perel, JM; Pollock, BG; Reynolds, CF; Yeager, AL, 1991)
"Predicted metabolic drug clearances (CLPT ) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®."1.39Predicted metabolic drug clearance with increasing adult age. ( Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD, 2013)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Polasek, TM1
Patel, F1
Jensen, BP1
Sorich, MJ1
Wiese, MD1
Doogue, MP1
Pollock, BG1
Perel, JM1
Kirshner, M1
Altieri, LP1
Yeager, AL1
Reynolds, CF1

Other Studies

2 other studies available for mephenytoin and Aging

ArticleYear
Predicted metabolic drug clearance with increasing adult age.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; M

2013
S-mephenytoin 4-hydroxylation in older Americans.
    European journal of clinical pharmacology, 1991, Volume: 40, Issue:6

    Topics: Aged; Aging; Aryl Hydrocarbon Hydroxylases; Black People; Chromatography, High Pressure Liquid; Crea

1991