mephenytoin has been researched along with Aging in 2 studies
Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine whether a drug-metabolizing enzyme changes with normal aging, the S:R index of S-mephenytoin 4-hydroxylation was determined in 150, unmedicated elderly Americans (mean age 75." | 3.68 | S-mephenytoin 4-hydroxylation in older Americans. ( Altieri, LP; Kirshner, M; Perel, JM; Pollock, BG; Reynolds, CF; Yeager, AL, 1991) |
| "Predicted metabolic drug clearances (CLPT ) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®." | 1.39 | Predicted metabolic drug clearance with increasing adult age. ( Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Polasek, TM | 1 |
| Patel, F | 1 |
| Jensen, BP | 1 |
| Sorich, MJ | 1 |
| Wiese, MD | 1 |
| Doogue, MP | 1 |
| Pollock, BG | 1 |
| Perel, JM | 1 |
| Kirshner, M | 1 |
| Altieri, LP | 1 |
| Yeager, AL | 1 |
| Reynolds, CF | 1 |
2 other studies available for mephenytoin and Aging
| Article | Year |
|---|---|
Predicted metabolic drug clearance with increasing adult age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; M | 2013 |
S-mephenytoin 4-hydroxylation in older Americans.
Topics: Aged; Aging; Aryl Hydrocarbon Hydroxylases; Black People; Chromatography, High Pressure Liquid; Crea | 1991 |