Page last updated: 2024-10-30

meperidine and Serotonin Syndrome

meperidine has been researched along with Serotonin Syndrome in 7 studies

Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.

Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.

Research Excerpts

ExcerptRelevanceReference
"We present a patient with a history of clomipramine-induced serotonin syndrome 5 yr prior who developed serotonin syndrome after a single dose of meperidine."7.75Meperidine-induced serotonin syndrome in a susceptible patient. ( Chien, CC; Guo, SL; Liu, CC; Ng, CC; Sun, HL; Wu, TJ, 2009)
"Serotonin syndrome has been reported with administration of linezolid and serotonin reuptake inhibitors."7.74Serotonin syndrome after concomitant treatment with linezolid and meperidine. ( Das, PK; Forrest, DL; Hewko, R; Warkentin, DI, 2008)
"We present a patient with a history of clomipramine-induced serotonin syndrome 5 yr prior who developed serotonin syndrome after a single dose of meperidine."3.75Meperidine-induced serotonin syndrome in a susceptible patient. ( Chien, CC; Guo, SL; Liu, CC; Ng, CC; Sun, HL; Wu, TJ, 2009)
"Serotonin syndrome has been reported with administration of linezolid and serotonin reuptake inhibitors."3.74Serotonin syndrome after concomitant treatment with linezolid and meperidine. ( Das, PK; Forrest, DL; Hewko, R; Warkentin, DI, 2008)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's6 (85.71)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Guo, SL1
Wu, TJ1
Liu, CC1
Ng, CC1
Chien, CC1
Sun, HL1
Cohen, MR1
Dougherty, JA1
Young, H1
Shafi, T1
Tissot, TA1
Das, PK1
Warkentin, DI1
Hewko, R1
Forrest, DL1
Weiner, AL1
Giese, SY1
Neborsky, R1

Other Studies

7 other studies available for meperidine and Serotonin Syndrome

ArticleYear
Meperidine-induced serotonin syndrome in a susceptible patient.
    British journal of anaesthesia, 2009, Volume: 103, Issue:3

    Topics: Adult; Analgesics, Opioid; Clomipramine; Humans; Male; Meperidine; Pain, Postoperative; Selective Se

2009
Poison control center. Administering advice.
    Nursing, 2002, Volume: 32, Issue:6

    Topics: Analgesics, Opioid; Diagnosis, Differential; Drug Overdose; Female; Humans; Meperidine; Middle Aged;

2002
Serotonin syndrome induced by amitriptyline, meperidine, and venlafaxine.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:10

    Topics: Adult; Amitriptyline; Analgesics; Antifungal Agents; Cyclohexanols; Drug Interactions; Female; Fluco

2002
Probable meperidine-induced serotonin syndrome in a patient with a history of fluoxetine use.
    Anesthesiology, 2003, Volume: 98, Issue:6

    Topics: Adult; Analgesics, Opioid; Cholangiopancreatography, Endoscopic Retrograde; Diabetes Mellitus, Type

2003
Serotonin syndrome after concomitant treatment with linezolid and meperidine.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Jan-15, Volume: 46, Issue:2

    Topics: Acetamides; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Interactions; Drug Therapy,

2008
Meperidine as a potential cause of serotonin syndrome in the emergency department.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1999, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Emergency Treatment; Female; Humans; Male; Meperidine;

1999
Serotonin syndrome: potential consequences of Meridia combined with Demerol or fentanyl.
    Plastic and reconstructive surgery, 2001, Volume: 107, Issue:1

    Topics: Analgesics, Opioid; Antidepressive Agents; Appetite Depressants; Cyclobutanes; Drug Interactions; Fe

2001