meperidine has been researched along with Seizures in 60 studies
Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report three cases of meperidine-related seizures when meperidine was administered via patient-controlled analgesia pump (PCAP) and to review literature related to meperidine-associated seizures." | 8.78 | Meperidine-related seizures associated with patient-controlled analgesia pumps. ( Hagmeyer, KO; Mauro, LS; Mauro, VF, 1993) |
| "We describe the first reported case of generalized tonic-clonic seizures induced by meperidine premedication for a colonoscopy procedure in a 63-year-old woman with Alzheimer's disease." | 7.74 | Seizures in an Alzheimer's disease patient as a complication of colonoscopy premedication with meperidine. ( Hammarth, PM; Nagler, J; Poppers, DM, 2008) |
| "Semiologies were reviewed to ascertain seizure likelihood." | 6.52 | Seizures and Meperidine: Overstated and Underutilized. ( Hemmen, TM; Lyden, PD; Schlick, KH, 2015) |
| "Reports of seizures associated with meperidine have led to a growing reliance on intravenous morphine, usually with patient-controlled devices." | 5.30 | Low frequency of meperidine-associated seizures in sickle cell disease. ( Nadvi, SZ; Ravindranath, Y; Sarnaik, S, 1999) |
| " Morphine, pethidine and fentanyl, which showed a biphasic dose-response relationship with respect to seizure modulation, abolished the anticonvulsant activity of propofol to exhibit their own intrinsic activity in proconvulsant doses." | 5.29 | Interactions between opioid drugs and propofol in laboratory models of seizures. ( Ahmad, I; Pleuvry, BJ, 1995) |
| "Normeperidine-induced seizures in patients with porphyria may be treated by withdrawal of meperidine therapy and selective use of anticonvulsants." | 5.28 | Normeperidine-induced seizures in hereditary coproporphyria. ( Deeg, MA; Rajamani, K, 1990) |
| "To report three cases of meperidine-related seizures when meperidine was administered via patient-controlled analgesia pump (PCAP) and to review literature related to meperidine-associated seizures." | 4.78 | Meperidine-related seizures associated with patient-controlled analgesia pumps. ( Hagmeyer, KO; Mauro, LS; Mauro, VF, 1993) |
| "We describe the first reported case of generalized tonic-clonic seizures induced by meperidine premedication for a colonoscopy procedure in a 63-year-old woman with Alzheimer's disease." | 3.74 | Seizures in an Alzheimer's disease patient as a complication of colonoscopy premedication with meperidine. ( Hammarth, PM; Nagler, J; Poppers, DM, 2008) |
| " The anticonvulsant activity of F1,6BP was determined in rat models of acute seizures induced by pilocarpine, kainic acid, or pentylenetetrazole." | 3.74 | Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats. ( Khan, FA; Lian, XY; Stringer, JL, 2007) |
| " Meperidine (Demerol [Abbott, Abbott Park, IL]) has been used for many years in the postoperative setting for pain control; however, in high doses, it has been associated with seizure." | 3.72 | Meperidine-induced seizure after revision hip arthroplasty. ( Beaulé, PE; Nguyen, VN; Smith, MI, 2004) |
| " 1988), 79 patients of eclampsia were treated with lytic cocktail and in time period B (April 1992-April 1994), 104 eclamptic patients were treated with magnesium sulfate." | 3.70 | Comparison of lytic cocktail and magnesium sulphate regimens in eclampsia: a retrospective analysis. ( Rani, K; Sawhney, H; Vasishta, K, 1998) |
| "Pethidine/promethazine and fentanyl/droperidol reduced the susceptibility to seizures induced by electroshock." | 3.67 | [The effect of neuroleptics and neuroleptic/analgesic combinations on the sensitivity to seizures in mice]. ( Frey, HH; Hashem, A, 1988) |
| "Meperidine neurotoxicity manifests as shakiness, tremors, myoclonus, and seizures." | 3.67 | Neurotoxicity of meperidine. ( Goetting, MG; Thirman, MJ, 1985) |
| "Twenty opioids have been subdivided into four classes by using flurothyl-induced seizures in rats to measure dose-response relationships, stereospecificity, naloxone sensitivity, and tolerance-cross-tolerance." | 3.66 | Classification of opioids on the basis of change in seizure threshold in rats. ( Adler, MW; Cowan, A; Geller, EB, 1979) |
| "Semiologies were reviewed to ascertain seizure likelihood." | 2.52 | Seizures and Meperidine: Overstated and Underutilized. ( Hemmen, TM; Lyden, PD; Schlick, KH, 2015) |
| "Meperidine is an opiod analgesic used in a variety of clinical situations." | 1.38 | [Convulsion due to application of low dose meperidine: a case report]. ( Akbaş, M; Akcan, AB; Aydemir, G; Ozkaya, H, 2012) |
| "The latency and incidence of seizures were recorded by an observer who was uninformed of the estrous cycle and dietary treatment conditions of the rats." | 1.33 | Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. ( Frye, CA; Harney, JP; Rhodes, ME; Talluri, J, 2005) |
| "To report a seizure occurring secondary to meperidine treatment despite normal renal and central nervous system (CNS) function, and to provide a review of meperidine's role in pain management, including its use in pancreatitis and sphincter of Oddi dysfunction." | 1.32 | Meperidine misuse in a patient with sphincter of Oddi dysfunction. ( Hubbard, GP; Wolfe, KR, 2003) |
| "Reports of seizures associated with meperidine have led to a growing reliance on intravenous morphine, usually with patient-controlled devices." | 1.30 | Low frequency of meperidine-associated seizures in sickle cell disease. ( Nadvi, SZ; Ravindranath, Y; Sarnaik, S, 1999) |
| " Morphine, pethidine and fentanyl, which showed a biphasic dose-response relationship with respect to seizure modulation, abolished the anticonvulsant activity of propofol to exhibit their own intrinsic activity in proconvulsant doses." | 1.29 | Interactions between opioid drugs and propofol in laboratory models of seizures. ( Ahmad, I; Pleuvry, BJ, 1995) |
| "Four patients had generalized seizures only with meperidine administration, all of whom had nonfocal EEG and radiological studies." | 1.29 | The spectrum of epilepsy in sickle cell anemia. ( Ballas, SK; Gzesh, DJ; Liu, JE, 1994) |
| "Normeperidine-induced seizures in patients with porphyria may be treated by withdrawal of meperidine therapy and selective use of anticonvulsants." | 1.28 | Normeperidine-induced seizures in hereditary coproporphyria. ( Deeg, MA; Rajamani, K, 1990) |
| "Mean seizure thresholds for control groups (i." | 1.27 | A selective role for delta-receptors in the regulation of opioid-induced changes in seizure threshold. ( Cowan, A; Holaday, JW; Robles, LE; Tortella, FC, 1983) |
| "All three opioids are reported to lower seizure thresholds when given subcutaneously to rats in this test." | 1.27 | Studies on the excitatory and inhibitory influence of intracerebroventricularly injected opioids on seizure thresholds in rats. ( Adler, MW; Cowan, A; Tortella, FC, 1984) |
| "Normeperidine levels were 0." | 1.26 | Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer. ( Cheigh, J; Houde, R; Inturrisi, CE; Reidenberg, MM; Saal, S; Szeto, HH, 1977) |
| "Pretreatment with naloxone (60 mg/kg i." | 1.25 | Antagonism of the convulsant effects of heroin, d-propoxyphene, meperidine, normeperidine and thebaine by naloxone in mice. ( Gilbert, PE; Martin, WR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (56.67) | 18.7374 |
| 1990's | 15 (25.00) | 18.2507 |
| 2000's | 7 (11.67) | 29.6817 |
| 2010's | 4 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reifenrath, WG | 1 |
| Roche, EB | 1 |
| Al-Turk, WA | 1 |
| Johnson, HL | 1 |
| Carter, C | 1 |
| Viveash, S | 1 |
| Schlick, KH | 1 |
| Hemmen, TM | 1 |
| Lyden, PD | 1 |
| Luo, W | 1 |
| Li, YL | 1 |
| Yu, Q | 1 |
| Li, YS | 1 |
| Guo, SL | 1 |
| Gozdemir, M | 1 |
| Muslu, B | 1 |
| Usta, B | 1 |
| Sert, H | 1 |
| Demircioglu, RI | 1 |
| Gumus, II | 1 |
| Yillar, DO | 1 |
| Akkan, AG | 1 |
| Akcasu, A | 1 |
| Ozüner, Z | 1 |
| Eşkazan, E | 1 |
| Küçukhüseyin, C | 1 |
| Ozkaya, H | 1 |
| Akcan, AB | 1 |
| Aydemir, G | 1 |
| Akbaş, M | 1 |
| Hubbard, GP | 1 |
| Wolfe, KR | 1 |
| BLUMEL, G | 1 |
| KUCHER, R | 1 |
| HAMBURGER, E | 1 |
| ALEXANDER, JA | 1 |
| ROGERS, SF | 1 |
| JACOBS, WM | 1 |
| WILLS, SH | 1 |
| Beaulé, PE | 1 |
| Smith, MI | 1 |
| Nguyen, VN | 1 |
| Rhodes, ME | 1 |
| Talluri, J | 1 |
| Harney, JP | 1 |
| Frye, CA | 1 |
| Nagler, J | 1 |
| Hammarth, PM | 1 |
| Poppers, DM | 1 |
| Lian, XY | 1 |
| Khan, FA | 1 |
| Stringer, JL | 1 |
| Waterhouse, RG | 1 |
| Emele, JF | 1 |
| Shanaman, JE | 1 |
| Tortella, FC | 2 |
| Robles, LE | 1 |
| Holaday, JW | 1 |
| Cowan, A | 4 |
| Adler, MW | 3 |
| Hershey, LA | 1 |
| Leander, JD | 2 |
| Ahmad, I | 1 |
| Pleuvry, BJ | 1 |
| Adair, JC | 1 |
| Gilmore, RL | 1 |
| Liu, JE | 1 |
| Gzesh, DJ | 1 |
| Ballas, SK | 1 |
| Hagmeyer, KO | 1 |
| Mauro, LS | 1 |
| Mauro, VF | 2 |
| Hinnant, DC | 1 |
| Emerson, GM | 1 |
| Oxer, HF | 1 |
| Kussman, BD | 1 |
| Sethna, NF | 1 |
| Sawhney, H | 1 |
| Vasishta, K | 1 |
| Rani, K | 1 |
| Marinella, MA | 1 |
| McHugh, GJ | 1 |
| Nadvi, SZ | 1 |
| Sarnaik, S | 1 |
| Ravindranath, Y | 1 |
| Dykstra, LA | 1 |
| Geller, EB | 2 |
| Rainier-Pope, CR | 1 |
| Mashkova, D | 1 |
| Kolchev, Kh | 1 |
| Kotev, G | 1 |
| Szeto, HH | 1 |
| Inturrisi, CE | 1 |
| Houde, R | 1 |
| Saal, S | 1 |
| Cheigh, J | 1 |
| Reidenberg, MM | 1 |
| Gilbert, PE | 1 |
| Martin, WR | 1 |
| Goonewardene, TW | 1 |
| Sentheshanmuganathan, S | 1 |
| Kamalanathan, S | 1 |
| Kanagasunderam, R | 1 |
| Pegelow, CH | 1 |
| Pryle, BJ | 1 |
| Grech, H | 1 |
| Stoddart, PA | 1 |
| Carson, R | 1 |
| O'Mahoney, T | 1 |
| Reynolds, F | 1 |
| Deeg, MA | 1 |
| Rajamani, K | 1 |
| Kyff, JV | 1 |
| Rice, TL | 1 |
| Greenslade, GL | 1 |
| Hashem, A | 1 |
| Frey, HH | 1 |
| Bonfiglio, MF | 1 |
| Spunt, AL | 1 |
| Armstrong, PJ | 1 |
| Bersten, A | 1 |
| El-Kadre, D | 1 |
| Goetting, MG | 1 |
| Thirman, MJ | 1 |
| Pearl, J | 2 |
| Harris, LS | 2 |
| Frank, GB | 2 |
| Jhamandas, K | 2 |
| Granat, FR | 1 |
| Saelens, JK | 1 |
| Huidobro, F | 1 |
| Bennett, CR | 1 |
| Monheim, LM | 1 |
| Ruskin, P | 1 |
| Wikinski, JA | 1 |
| Usubiaga, JE | 1 |
| Wikinski, RW | 1 |
| Rosenberg, FJ | 1 |
| Cooke, WJ | 1 |
| Wessinger, GD | 1 |
| Aceto, MD | 1 |
| Duffus, GM | 1 |
| Tunstall, ME | 1 |
| Condie, RG | 1 |
| MacGillivray, I | 1 |
2 reviews available for meperidine and Seizures
| Article | Year |
|---|---|
Seizures and Meperidine: Overstated and Underutilized.
Topics: Analgesics, Opioid; Humans; Meperidine; Pain Threshold; Risk Assessment; Risk Factors; Seizures; Shi | 2015 |
Meperidine-related seizures associated with patient-controlled analgesia pumps.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Epilepsy, Tonic-Clonic; Female; Humans; Ketorolac; | 1993 |
58 other studies available for meperidine and Seizures
| Article | Year |
|---|---|
Synthesis and biological activity of fluoroalkylamine derivatives of narcotic analgesics.
Topics: Analgesics, Opioid; Animals; Benzomorphans; Guinea Pigs; Haplorhini; Humans; Male; Meperidine; Mice; | 1980 |
Nursing a critically ill tetanus patient in an intensive care unit in Zambia.
Topics: Analgesics, Opioid; Anti-Infective Agents; Anticonvulsants; Back Pain; Critical Care Nursing; Critic | 2017 |
Meperidine-induced Seizure in an Adult Patient with Lung Lesions.
Topics: Analgesics, Opioid; Female; Humans; Lung Neoplasms; Meperidine; Middle Aged; Seizures; Tomography, X | 2016 |
Generalized seizure in patient receiving epidural meperidine during cesarean section.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Cesarean Section; Female; Humans; Meperidine; Pa | 2008 |
The effect of oral and subcutaneous meperidine on the maximal electroshock seizure (MES) in mice.
Topics: Administration, Oral; Animals; Cerebellar Cortex; Dose-Response Relationship, Drug; Electroshock; Fe | 2009 |
[Convulsion due to application of low dose meperidine: a case report].
Topics: Analgesics, Opioid; Child; Diagnosis, Differential; Femoral Fractures; Humans; Male; Meperidine; Pai | 2012 |
Meperidine misuse in a patient with sphincter of Oddi dysfunction.
Topics: Analgesics, Opioid; Buprenorphine; Common Bile Duct Diseases; Female; Humans; Meperidine; Middle Age | 2003 |
[Contribution to the therapy of non-hemolytic blood transfusion disorders].
Topics: Blood Transfusion; Chlorpromazine; Cyanosis; Humans; Meperidine; Platelet Transfusion; Promethazine; | 1962 |
BARBITURATE USE IN NARCOTIC ADDICTS.
Topics: Barbiturates; Codeine; Drug Tolerance; Ethchlorvynol; Glutethimide; Heroin; Hydromorphone; Hypnotics | 1964 |
CESAREAN SECTION IN THE ECLAMPTIC PATIENT ON ANTIHYPERTENSIVE THERAPY: A REVIEW OF FOURTEEN CASES.
Topics: Adolescent; Anesthesia; Antihypertensive Agents; Cesarean Section; Child; Drug Therapy; Eclampsia; F | 1964 |
Meperidine-induced seizure after revision hip arthroplasty.
Topics: Acetabulum; Adult; Analgesics; Arthroplasty, Replacement, Hip; Female; Hip Dislocation; Humans; Mepe | 2004 |
Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats.
Topics: Allylamine; Analysis of Variance; Animals; Animals, Newborn; Diet; Disease Models, Animal; Drug Comb | 2005 |
Seizures in an Alzheimer's disease patient as a complication of colonoscopy premedication with meperidine.
Topics: Adjuvants, Anesthesia; Alzheimer Disease; Colitis, Lymphocytic; Colonoscopy; Female; Follow-Up Studi | 2008 |
Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats.
Topics: Acute Disease; Allylamine; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Deoxygl | 2007 |
Epileptiform convulsions in children following premedication with Pamergan SP100.
Topics: Body Weight; Child; Female; Humans; Injections, Intramuscular; Male; Meperidine; Promethazine; Scopo | 1967 |
Analgesic acitivity of namoxyrate (2-[4-biphenylyl] butyric acid 2-dimethylaminoethanol salt).
Topics: Amino Alcohols; Analgesics; Animals; Aspirin; Biphenyl Compounds; Bradykinin; Butyrates; Codeine; De | 1967 |
A selective role for delta-receptors in the regulation of opioid-induced changes in seizure threshold.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Meperidine; Rats; Rats | 1983 |
Studies on the excitatory and inhibitory influence of intracerebroventricularly injected opioids on seizure thresholds in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Flurothyl; Injections, Intraventricular; Male; Mep | 1984 |
Meperidine and central neurotoxicity.
Topics: Central Nervous System Diseases; Humans; Meperidine; Myoclonus; Seizures | 1983 |
Interaction of diazepam with meperidine or normeperidine on analgesia and lethality.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Male; Meperidine; Nociceptor | 1982 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; | 1995 |
Meperidine neurotoxicity after organ transplantation.
Topics: Adult; Central Nervous System; Humans; Kidney Transplantation; Male; Meperidine; Pancreas Transplant | 1994 |
The spectrum of epilepsy in sickle cell anemia.
Topics: Adult; Anemia, Sickle Cell; Brain; Electroencephalography; Epilepsy; Female; Humans; Magnetic Resona | 1994 |
Minimizing meperidine use.
Topics: Acute Disease; Aged; Analgesics, Opioid; Contraindications; Humans; Meperidine; Pain; Practice Patte | 1996 |
Unusual causes of convulsions in a hyperbaric chamber.
Topics: Adult; Analgesics, Opioid; Diving; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Humans; Hy | 1998 |
Pethidine-associated seizure in a healthy adolescent receiving pethidine for postoperative pain control.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Humans; Male; Meperidine; Pain, Posto | 1998 |
Comparison of lytic cocktail and magnesium sulphate regimens in eclampsia: a retrospective analysis.
Topics: Adult; Analgesics, Opioid; Anticonvulsants; Blood Pressure; Central Nervous System Agents; Chlorprom | 1998 |
Medical causes of seizure.
Topics: Analgesics, Opioid; Humans; Meperidine; Seizures | 1998 |
Norpethidine accumulation and generalized seizure during pethidine patient-controlled analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Female; Humans; Ileostomy; Laparotomy; Mep | 1999 |
Low frequency of meperidine-associated seizures in sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Female; Humans; Infant; Infant, Newborn; Injections, Intravenous; M | 1999 |
Electric shock titration: effects of meperidine, anileridine and alphaprodine.
Topics: Alphaprodine; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroshock; Haplorhini; | 1978 |
Differential effects of opioids on flurothyl seizure thresholds in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Flurothyl; Male; Meperidine; Narcotics; P | 1979 |
Drug-induced extrapyramidal symptoms.
Topics: Cyclizine; Diagnosis, Differential; Extrapyramidal Tracts; Humans; Meperidine; Seizures; Seizures, F | 1979 |
Classification of opioids on the basis of change in seizure threshold in rats.
Topics: Animals; Drug Tolerance; Flurothyl; Male; Meperidine; Naloxone; Narcotics; Pentazocine; Rats; Seizur | 1979 |
[Electrophysiologic shifts in the functional antagonism between phosphororganic pesticides and their antidotes].
Topics: Animals; Brain; Cats; Electrocardiography; Electroencephalography; Electromyography; Heart; Insectic | 1977 |
Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer.
Topics: Acute Kidney Injury; Adult; Aged; Analgesia; Female; Humans; Male; Meperidine; Middle Aged; Neoplasm | 1977 |
Antagonism of the convulsant effects of heroin, d-propoxyphene, meperidine, normeperidine and thebaine by naloxone in mice.
Topics: Animals; Anticonvulsants; Dextropropoxyphene; Heroin; Male; Meperidine; Mice; Naloxone; Nipecotic Ac | 1975 |
Accidental subarachnoid injection of gallamine. A case report.
Topics: Anesthesia, Spinal; Blood Pressure; Chromatography, Thin Layer; Dexamethasone; Diazepam; Gallamine T | 1975 |
Survey of pain management therapy provided for children with sickle cell disease.
Topics: Acetaminophen; Analgesics; Anemia, Sickle Cell; Child; Child, Preschool; Codeine; Drug Administratio | 1992 |
Toxicity of norpethidine in sickle cell crisis.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Cholinesterase Inhibitors; Female; Humans; Male; Meperidine; | 1992 |
Normeperidine-induced seizures in hereditary coproporphyria.
Topics: Adult; Cholinesterase Inhibitors; Coproporphyrins; Female; Humans; Infant; Liver Diseases; Meperidin | 1990 |
Meperidine-associated seizures in a child.
Topics: Child, Preschool; Humans; Male; Meperidine; Seizures | 1990 |
Management of heat stroke.
Topics: Chlorpromazine; Heat Exhaustion; Humans; Meperidine; Seizures | 1989 |
[The effect of neuroleptics and neuroleptic/analgesic combinations on the sensitivity to seizures in mice].
Topics: Analgesics; Animals; Antipsychotic Agents; Disease Susceptibility; Droperidol; Drug Interactions; Fe | 1988 |
Meperidine-induced seizure in a patient without renal dysfunction or sickle cell anemia.
Topics: Adult; Drug Interactions; Female; Humans; Meperidine; Prochlorperazine; Seizures | 1986 |
Normeperidine toxicity.
Topics: Adult; Biotransformation; Colonic Neoplasms; Diazepam; Female; Humans; Injections, Intramuscular; Me | 1986 |
The "lytic cocktail" induces recurrence of fits in the treatment of eclampsia.
Topics: Chlorpromazine; Delivery, Obstetric; Eclampsia; Female; Humans; Labor, Obstetric; Meperidine; Pregna | 1985 |
Neurotoxicity of meperidine.
Topics: Administration, Oral; Adult; Emergencies; Female; Hamartoma; Humans; Kidney Neoplasms; Meperidine; M | 1985 |
Inhibition of writhing by narcotic antagonists.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Drug Antagonism; Meperidine; Mice; | 1966 |
Effects of drugs acting alone and in combination on the motor activity of intact mice.
Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central | 1970 |
Effect of stimulus intensity on the potency of some analgetic agents.
Topics: Analgesics; Animals; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Interaction | 1973 |
Action of picric acid on the effects of some drugs acting on the central nervous system, with special reference to opioids.
Topics: Amphetamine; Analgesia; Analgesics; Animals; Benzimidazoles; Drug Synergism; Female; Male; Meperidin | 1971 |
Effectiveness of various doses of premedicating drugs used for dental procedures in altering toxicity of procaine and lidocaine.
Topics: Dental Care; Drug Synergism; Lidocaine; Meperidine; Preanesthetic Medication; Procaine; Promethazine | 1971 |
Cardiovascular and neurological effects of 4,000 mg of procaine.
Topics: Adult; Aminobenzoates; Atropine; Bis-Trimethylammonium Compounds; Blood Pressure; Electrocardiograph | 1970 |
Effects of general depressant drugs on the electrical responses of isolated slabs of cat's cerebral cortex.
Topics: Action Potentials; Aminobutyrates; Anesthesia, General; Anesthesia, Local; Animals; Cats; Cerebral C | 1970 |
The effect of central nervous system depressants on the tolerance to local anesthetic solutions.
Topics: Anesthetics, Local; Animals; Barbiturates; Chlorpromazine; Drug Synergism; Lidocaine; Male; Meperidi | 1971 |
Prevention of writhing and other effects of narcotics and narcotic antagonists in mice.
Topics: Analgesics; Animals; Behavior, Animal; Bridged-Ring Compounds; Male; Meperidine; Mice; Morphine; Nal | 1968 |
Chlormethiazole in the prevention of eclampsia and the reduction of perinatal mortality.
Topics: Adolescent; Adult; Birth Weight; Chlormethiazole; Drug Synergism; Eclampsia; Female; Humans; Hypnoti | 1969 |