meperidine has been researched along with Neoplasms in 41 studies
Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Out of the 29 patients with more than one day of PCA, the median (range) of the Mean Pain Score was 44 (13-72) and 33 (3-89) in the morphine (n = 14) and pethidine (n = 15) groups, respectively (P = 0." | 9.15 | PCA analgesia for children with chemotherapy-related mucositis: a double-blind randomized comparison of morphine and pethidine. ( Allonier, C; Demirdjian, S; Hartmann, O; Iacobelli, S; Laplanche, A; Michon, J; Orbach, D; Oudot, C; Pagnier, A; Pein, F; Pichard-Leandri, E; Raimondo, G, 2011) |
| " Out of the 29 patients with more than one day of PCA, the median (range) of the Mean Pain Score was 44 (13-72) and 33 (3-89) in the morphine (n = 14) and pethidine (n = 15) groups, respectively (P = 0." | 5.15 | PCA analgesia for children with chemotherapy-related mucositis: a double-blind randomized comparison of morphine and pethidine. ( Allonier, C; Demirdjian, S; Hartmann, O; Iacobelli, S; Laplanche, A; Michon, J; Orbach, D; Oudot, C; Pagnier, A; Pein, F; Pichard-Leandri, E; Raimondo, G, 2011) |
| " In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
| "Hyperalgesia and allodynia in 4 cancer patients treated with morphine disappeared after discontinuing or substituting morphine with other opioid agonists." | 3.69 | Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists. ( Jensen, NH; Jensen, TS; Sjøgren, P, 1994) |
| " Twelve patients with pain secondary to cancer were simultaneously administered both morphine (10 mg) and pethidine (50 mg) in 10 ml of normal saline via an epidural catheter inserted in the lumbar region (usually L2,3) and attached to a subcutaneously implanted portal reservoir." | 3.67 | The influence of drug polarity on the absorption of opioid drugs into CSF and subsequent cephalad migration following lumbar epidural administration: application to morphine and pethidine. ( Armstrong, PJ; Cherry, DA; Cousins, MJ; Gourlay, GK; Plummer, JL, 1987) |
| "Effective analgesia resulted from the injection of peridural meperidine in two groups of cancer patients, eight with postoperative pain and eight with intractable pain." | 3.66 | Peridural meperidine in humans: analgesic response, pharmacokinetics, and transmission into CSF. ( Cousins, MJ; Glynn, CJ; Graham, JR; Mather, LE; Wilson, PR, 1981) |
| "Treatment with meperidine hydrochloride, currently the most widely used medication for controlling amphotericin B-induced shivering, was compared with nefopam hydrochloride, which has been successfully used to treat post-operative shivering." | 2.68 | Efficacy of nefopam for the prevention and treatment of amphotericin B-induced shivering. ( Cogliati, A; Conti, G; Dell'Utri, D; Gasparetto, A; Orsi, P; Pelaia, P; Rosa, G, 1997) |
| "The low prescription rate of opioids in chronic pain in Taiwan is not similar as those in high opioid-consuming countries, such as United States." | 1.72 | Prevalence of opioid prescriptions in Taiwan (2008-2018). ( Chu, CC; Chu, LL; Chu, YR; Ho, CH; Teng, SF; Wang, JJ, 2022) |
| "Ten patients with neuropathic cancer pain, not responding to conventional opioid therapy, were treated with continuous intrathecal administration of meperidine." | 1.33 | Plasma concentrations of meperidine and normeperidine following continuous intrathecal meperidine in patients with neuropathic cancer pain. ( Kruis, MR; van der Vegt, MH; van Kan, HJ; Vranken, JH, 2005) |
| "Insufficient knowledge about cancer pain on the part of physicians is an important factor responsible for ineffective cancer pain relief." | 1.33 | Physicians' knowledge about pharmacological management of cancer pain--with special reference on their prescribing responses to simulated patients with cancer pain. ( Ger, LP; Ho, ST; Lai, KH; Lee, MC; Sun, WZ; Wong, JO; Wu, HB, 2006) |
| "Induction of apoptosis in cancer cells by anti-cancer drugs and biosynthetic inhibitors of cells surface glycolipids in the human colon carcinoma cells (Colo-205) are of interest in recent years." | 1.32 | Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP. ( Banerjee, S; Basu, M; Basu, S; Bradley, M; Inokuchi, J; Ma, R; Mikulla, B; Moulton, C, 2004) |
| " Comparison of data from the two observation periods showed the following: Average relative bioavailability 0." | 1.28 | Bioavailability and analgesic effect of sustained release cetobemidone capsules in cancer patients with chronic pain of malignant origin. ( Andersen, LS; Kjaer, M; Nielsen, H; Olsen, FE; Philipsen, J; Velander, G, 1992) |
| "Continuous Reaction Time (CRT) was measured in cancer patients receiving peripherally acting analgesics either alone (n = 16) or in combination with opioids (n = 16)." | 1.28 | Reaction time in cancer patients receiving peripherally acting analgesics alone or in combination with opioids. ( Banning, A; Kaiser, F; Sjøgren, P, 1992) |
| "195 children with cancer diagnosed in 1971-March 1991 and born in the two major Bristol maternity hospitals in 1965-87 were compared with 558 controls identified from the delivery books for the use of pethidine during labour and administration of vitamin K." | 1.28 | Childhood cancer, intramuscular vitamin K, and pethidine given during labour. ( Birmingham, K; Golding, J; Greenwood, R; Mott, M, 1992) |
| "90 (SD) and the mean relative bioavailability of the mixture was slightly above 100%." | 1.27 | Analgesic effect and bioavailability of oral ketogan given as tablets or mixture to patients with chronic pain of malignant origin. ( Kjaer, M; Nielsen, H, 1988) |
| "Normeperidine levels were 0." | 1.26 | Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer. ( Cheigh, J; Houde, R; Inturrisi, CE; Reidenberg, MM; Saal, S; Szeto, HH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (51.22) | 18.7374 |
| 1990's | 9 (21.95) | 18.2507 |
| 2000's | 8 (19.51) | 29.6817 |
| 2010's | 2 (4.88) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Tukey, RH | 1 |
| Strassburg, CP | 1 |
| Wang, JJ | 1 |
| Chu, YR | 1 |
| Teng, SF | 1 |
| Chu, CC | 1 |
| Ho, CH | 1 |
| Chu, LL | 1 |
| Oudot, C | 1 |
| Laplanche, A | 1 |
| Orbach, D | 1 |
| Pein, F | 1 |
| Michon, J | 1 |
| Raimondo, G | 1 |
| Pichard-Leandri, E | 1 |
| Allonier, C | 1 |
| Iacobelli, S | 1 |
| Pagnier, A | 1 |
| Demirdjian, S | 1 |
| Hartmann, O | 1 |
| Kim, MH | 1 |
| Park, H | 1 |
| Park, EC | 1 |
| Park, K | 1 |
| SAUR, HT | 1 |
| COENEN, W | 1 |
| PHILIPSZOON, AJ | 1 |
| BOS, JH | 1 |
| CHURCHILL-DAVIDSON, I | 1 |
| Weinman, BP | 1 |
| Basu, S | 1 |
| Ma, R | 1 |
| Mikulla, B | 1 |
| Bradley, M | 1 |
| Moulton, C | 1 |
| Basu, M | 1 |
| Banerjee, S | 1 |
| Inokuchi, J | 1 |
| Vranken, JH | 2 |
| van der Vegt, MH | 2 |
| van Kan, HJ | 2 |
| Kruis, MR | 1 |
| Wu, HB | 1 |
| Lee, MC | 1 |
| Lai, KH | 1 |
| Ho, ST | 1 |
| Sun, WZ | 1 |
| Wong, JO | 1 |
| Ger, LP | 1 |
| Kaiko, RF | 2 |
| Foley, KM | 1 |
| Grabinski, PY | 1 |
| Heidrich, G | 1 |
| Rogers, AG | 1 |
| Inturrisi, CE | 4 |
| Reidenberg, MM | 2 |
| Enig, B | 1 |
| Stambaugh, JE | 1 |
| Lane, C | 1 |
| Wallenstein, SL | 1 |
| Rogers, A | 1 |
| Grabinski, P | 1 |
| Houde, RW | 1 |
| Rankin, MA | 1 |
| Gustafsson, LL | 1 |
| Garle, M | 1 |
| Johannisson, J | 1 |
| Rane, A | 1 |
| Stenport, J | 1 |
| Walson, P | 1 |
| Glynn, CJ | 1 |
| Mather, LE | 1 |
| Cousins, MJ | 2 |
| Graham, JR | 1 |
| Wilson, PR | 1 |
| Müller, H | 1 |
| Börner, U | 1 |
| Stoyanov, M | 1 |
| Gleumes, L | 1 |
| Hempelmann, G | 1 |
| Luczak, J | 1 |
| Sjøgren, P | 2 |
| Jensen, NH | 1 |
| Jensen, TS | 1 |
| Kjaer, M | 3 |
| Nielsen, H | 3 |
| Andersen, LS | 2 |
| Rosa, G | 1 |
| Dell'Utri, D | 1 |
| Conti, G | 1 |
| Pelaia, P | 1 |
| Cogliati, A | 1 |
| Orsi, P | 1 |
| Gasparetto, A | 1 |
| Pasero, C | 1 |
| McCaffery, M | 1 |
| Klepstad, P | 1 |
| Skogvoll, E | 1 |
| Kaasa, S | 1 |
| Borchgrevink, PC | 1 |
| Grier, MR | 1 |
| Howard, M | 1 |
| Cohen, F | 1 |
| Szeto, HH | 2 |
| Houde, R | 1 |
| Saal, S | 1 |
| Cheigh, J | 1 |
| Olsen, FE | 1 |
| Philipsen, J | 1 |
| Velander, G | 1 |
| Banning, A | 1 |
| Kaiser, F | 1 |
| Golding, J | 1 |
| Greenwood, R | 1 |
| Birmingham, K | 1 |
| Mott, M | 1 |
| Tunca, M | 1 |
| Yelken, J | 1 |
| Stirrat, G | 1 |
| Gourlay, GK | 1 |
| Cherry, DA | 1 |
| Plummer, JL | 1 |
| Armstrong, PJ | 1 |
| Ingemar, F | 1 |
| Ahlgren, H | 1 |
| Ahlgren, MBE | 1 |
| Coates, GT | 1 |
| Roelofs, RI | 1 |
| Engel, WK | 1 |
| Guliaev, GV | 1 |
| Goloskov, NP | 1 |
| Breusenko, EIa | 1 |
| Skvabchenkov, IuN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Survey of Knowledge and Attitude of Pain in Anesthesia Residents of Thailand[NCT05369923] | 140 participants (Anticipated) | Observational | 2022-10-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for meperidine and Neoplasms
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
6 trials available for meperidine and Neoplasms
| Article | Year |
|---|---|
PCA analgesia for children with chemotherapy-related mucositis: a double-blind randomized comparison of morphine and pethidine.
Topics: Adolescent; Analgesics, Opioid; Antineoplastic Agents; Child; Child, Preschool; Double-Blind Method; | 2011 |
[Sublingual buprenorphine in the treatment of pain caused by cancer. Transition to buprenorphine from other opiates].
Topics: Adult; Aged; Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Female; Humans; Male; Mepe | 1983 |
Regional epidural analgesia: kinetics of pethidine.
Topics: Anesthesia, Conduction; Anesthesia, Epidural; Animals; Humans; Injections, Spinal; Kinetics; Meperid | 1982 |
[Epidural application of opiates in chronic pain due to malignoma (author's transl)].
Topics: Adult; Aged; Catheterization; Female; Fentanyl; Humans; Male; Meperidine; Middle Aged; Morphine; Nar | 1981 |
[Bioavailability and analgetic effect of sustained-release ketobemidone capsules in patients with chronic pain of cancer].
Topics: Adult; Analgesics, Opioid; Biological Availability; Capsules; Delayed-Action Preparations; Female; H | 1993 |
Efficacy of nefopam for the prevention and treatment of amphotericin B-induced shivering.
Topics: Adult; Aged; Amphotericin B; Analgesics, Non-Narcotic; Analgesics, Opioid; Antifungal Agents; Antine | 1997 |
34 other studies available for meperidine and Neoplasms
| Article | Year |
|---|---|
Prevalence of opioid prescriptions in Taiwan (2008-2018).
Topics: Analgesics, Opioid; Chronic Pain; Drug Prescriptions; Humans; Meperidine; Morphine; Neoplasms; Oxyco | 2022 |
Attitude and knowledge of physicians about cancer pain management: young doctors of South Korea in their early career.
Topics: Adrenal Cortex Hormones; Adult; Analgesics, Opioid; Anticonvulsants; Antidepressive Agents; Attitude | 2011 |
[ON THE CONTROL OF PAIN IN CANCER].
Topics: Aminopyrine; Humans; Meperidine; Neoplasms; Pain | 1963 |
[THE DIRECTION OF SPONTANEOUS NYSTAGMUS AND POSITIONAL NYSTAGMUS].
Topics: Alcoholic Intoxication; Brain; Brain Neoplasms; Electrophysiology; Labyrinth Diseases; Meperidine; N | 1964 |
HYPERBARIC OXYGENATIN. THE SMALL PATIENT CHAMBER, RADIOTHERAPY.
Topics: Anesthesia; Anesthesia, Intravenous; Equipment and Supplies; Humans; Hyperbaric Oxygenation; Meperid | 1965 |
2003 LeTourneau Award. Freedom from pain. Establishing a constitutional right to pain relief.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Civil Rights; Female; Humans; Male; Meperidine; | 2003 |
Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP.
Topics: Antineoplastic Agents; Apoptosis; Carbon Radioisotopes; Caspase 3; Caspases; Cell Line, Tumor; Ceram | 2004 |
Plasma concentrations of meperidine and normeperidine following continuous intrathecal meperidine in patients with neuropathic cancer pain.
Topics: Aged; Analgesics, Opioid; Female; Humans; Injections, Spinal; Male; Meperidine; Middle Aged; Neoplas | 2005 |
Physicians' knowledge about pharmacological management of cancer pain--with special reference on their prescribing responses to simulated patients with cancer pain.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Drug Prescriptions; Female; Humans; Know | 2006 |
Stability and compatibility of a meperidine-clonidine mixture in portable pump reservoirs for the management of cancer pain syndromes.
Topics: Analgesics; Analgesics, Opioid; Clonidine; Complex Mixtures; Drug Combinations; Drug Stability; Huma | 2006 |
Central nervous system excitatory effects of meperidine in cancer patients.
Topics: Adolescent; Adult; Aged; Central Nervous System Diseases; Child; Emotions; Female; Humans; Male; Mep | 1983 |
Analgesic efficacy and pharmacokinetic evaluation of meperidine and hydroxyzine, alone and in combination.
Topics: Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Double-Blind Method; Dru | 1983 |
Relative analgesic potency of intramuscular heroin and morphine in cancer patients with postoperative pain and chronic pain due to cancer.
Topics: Adult; Aged; Analgesics; Chronic Disease; Female; Heroin; Humans; Injections, Intramuscular; Levorph | 1981 |
Use of drugs for pain with cancer patients.
Topics: Adult; Aged; Analgesics; Female; Humans; Hypnotics and Sedatives; Male; Meperidine; Middle Aged; Neo | 1982 |
Peridural meperidine in humans: analgesic response, pharmacokinetics, and transmission into CSF.
Topics: Adult; Aged; Catheterization; Epidural Space; Female; Humans; Kinetics; Male; Meperidine; Middle Age | 1981 |
Palliative/hospice care in Poland.
Topics: Drug Utilization; Forecasting; Hospices; Humans; Meperidine; Morphine; Neoplasms; Organizational Obj | 1993 |
Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists.
Topics: Adult; Aged; Analgesics, Opioid; Child; Delayed-Action Preparations; Female; Humans; Hyperalgesia; M | 1994 |
Hydromorphone.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Hydromorphone; Meperidine; Morphine; Neoplasms; Pain | 2001 |
Circadian distribution of oral opioid consumption in cancer patients.
Topics: Adult; Aged; Analgesics, Opioid; Circadian Rhythm; Drug Administration Schedule; Female; Humans; Mal | 2000 |
Beliefs and values associated with administering narcotic analgesic to terminally ill patients.
Topics: Analgesics, Opioid; Attitude of Health Personnel; Decision Making; Female; Humans; Male; Meperidine; | 1979 |
Disposition of narcotics in patients with renal disease.
Topics: Animals; Biotransformation; Half-Life; Humans; Kidney Failure, Chronic; Meperidine; Neoplasms | 1977 |
Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer.
Topics: Acute Kidney Injury; Adult; Aged; Analgesia; Female; Humans; Male; Meperidine; Middle Aged; Neoplasm | 1977 |
Simultaneous determination of meperidine and normeperidine in biofluids.
Topics: Amniotic Fluid; Animals; Cats; Chromatography, Gas; Chromatography, Liquid; Female; Humans; Male; Me | 1976 |
Bioavailability and analgesic effect of sustained release cetobemidone capsules in cancer patients with chronic pain of malignant origin.
Topics: Adult; Aged; Analgesics, Opioid; Biological Availability; Capsules; Delayed-Action Preparations; Fem | 1992 |
Reaction time in cancer patients receiving peripherally acting analgesics alone or in combination with opioids.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum | 1992 |
Childhood cancer, intramuscular vitamin K, and pethidine given during labour.
Topics: Administration, Oral; Analgesia, Obstetrical; Child; Child, Preschool; Confounding Factors, Epidemio | 1992 |
Undertreatment of cancer pain.
Topics: Humans; Meperidine; Morphine; Neoplasms; Pain | 1991 |
Epidemiology and the woman in the street.
Topics: Attitude to Health; Child; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meperidine; Neo | 1991 |
Analgesic effect and bioavailability of oral ketogan given as tablets or mixture to patients with chronic pain of malignant origin.
Topics: Administration, Oral; Adult; Aged; Allylamine; Amines; Drug Combinations; Female; Half-Life; Humans; | 1988 |
The influence of drug polarity on the absorption of opioid drugs into CSF and subsequent cephalad migration following lumbar epidural administration: application to morphine and pethidine.
Topics: Blood-Brain Barrier; Chemical Phenomena; Chemistry; Drug Therapy, Combination; Humans; Injections, E | 1987 |
Epidural administration of opiates by a new device.
Topics: Anesthesia, Epidural; Buprenorphine; Catheters, Indwelling; Humans; Infusion Pumps; Meperidine; Morp | 1987 |
Treatment for cancer pain.
Topics: Heroin; Humans; Meperidine; Neoplasms; Pain | 1986 |
Myopathies associated with systemic diseases.
Topics: Alcoholism; Anti-Bacterial Agents; Chloroquine; Collagen Diseases; Endocrine System Diseases; Erythe | 1971 |
[Effect of premedication with droperidol, atropine, and promedol on basic indices of blood circulation in patients with tumors of the head and neck].
Topics: Atropine; Blood Pressure; Cardiac Output; Droperidol; Electrocardiography; Head; Head and Neck Neopl | 1974 |