meperidine and Muscle Contraction studies

Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.

Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Research Excerpts

Excerpt	Relevance	Reference
"Mivacurium infusion was titrated to give a 90% block of first twitch height."	2.68	Recovery from mivacurium block with or without anticholinesterase following continuous infusion in obstetric patients. ( Chan, AM; Hui, TW; Jan, GS; Lo, JW; Tong, WN, 1996)
"In order to evaluate the anticholinergic effect of fentanyl and pethidine, the influence of these drugs on the cumulative dose-response curves of carbacholine on the guinea-pig ileum has been investigated."	1.29	Fentanyl and pethidine are antagonists on muscarinic receptors in guinea-pig ileum. ( Hustveit, O; Setekleiv, J, 1993)
"Pretreatment with atropine or naloxone reduced the frequency of contractions significantly (P less than 0."	1.28	Differing effects of pethidine and morphine on human sphincter of Oddi motility. ( Baker, RA; Owen, H; Saccone, GT; Thune, A; Toouli, J, 1990)
"Droperidol caused no increase in twitch, but it depressed the twitch by 50% at concentrations of 9."	1.27	Myoneural effects of pethidine and droperidol. ( Boros, M; Chaudhry, IA; Duncalf, RM; Foldes, FF; Nagashima, H; Sherman, EH, 1984)
" The effect of acetylcholine is also significantly potentiated by pretreatment with 6-hydroxydopamine or denervation, but not by reserpine, while the dose-response curve for carbachol is not affected by the specific cholinesterase inhibitor BW 284 C51, denervation or 6-hydroxydopamine."	1.26	Uptake and release of catecholamines in sympathetic nerve fibers in the spleen of the cod, Gadus morhua. ( Holmgren, S; Nilsson, S, 1976)

Research

Studies (39)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Duration of the Second Stage of Labour

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (89.74)	18.7374
1990's	4 (10.26)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
SCOGGIN, WA	1
MCGAUGHEY, HS	1
JOHNSON, WL	1
THORNTON, WN	1
ZOURLAS, PA	1
MARSHALL, M	1
Sica-Blanco, Y	1
Rozada, H	1
Remedio, MR	1
Filler, WW	1
Hall, WC	1
Filler, NW	1
Durham, HD	1
Frank, GB	2
Rattan, S	1
Goyal, RK	1
Waters, A	1
Harder, DR	1
Boros, M	1
Chaudhry, IA	1
Nagashima, H	1
Duncalf, RM	1
Sherman, EH	1
Foldes, FF	1
Zrubek, H	1
Doraczyński, H	1
Pańczyk, T	1
Oleszczuk, J	1
Sawulicka-Oleszczuk, H	1
Witkowski, G	1
Shen, JF	1
Lin, YF	1
Wu, QP	1
Hustveit, O	1
Setekleiv, J	1
Jan, GS	1
Tong, WN	1
Chan, AM	1
Hui, TW	1
Lo, JW	1
Sanna, SK	1
Daniel, EE	1
Waterfall, WE	1
Lewis, TD	1
Marzio, L	1
Holmgren, S	1
Nilsson, S	1
Sugai, N	1
Worsley, R	1
Payne, JP	1
Thune, A	1
Baker, RA	1
Saccone, GT	1
Owen, H	1
Toouli, J	1
Helgesen, KG	2
Tindall, A	2
Shetty, SS	1
Schneider, E	1
Brune, K	1
Bergsjo, P	1
Hughes, J	1
Kosterlitz, HW	1
Leslie, FM	1
Grundy, HF	1
Tritthart, H	1
Dunne, JT	1
Miliigan, JE	1
Thomas, BW	1
Epstein, RA	1
Jackson, SH	1
Bowman, WC	1
Buwembo, JB	1
Csapo, AI	1
Kivikoski, A	1
Wiest, WG	1
Lauersen, NH	1
Fuchs, F	1
Struthers, NW	1
Metz, HS	1
Rice, LS	1
Strauer, BE	1
Henmi, Z	1
Horii, D	1
Mitsushima, T	1
Kawazura, H	1
Hayashi, H	1
Fennessy, MR	1
Heimans, RL	1
Rand, MJ	1
DeVoe, SJ	2
DeVoe, K	1
Rigsby, WC	1
McDaniels, BA	1
Barclay, ML	1
Weinberg, JH	1
Aladjem, S	1
Zakut, H	1
Mannor, SM	1
Serr, DM	1
Vallvé, C	1
Sharkey, J	1
Kaplan, N	1
Newman, HR	1
Elkin, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Is There Any Effect of Meperidine on the Length of Duration of Labor? A Prospective Randomized Controlled Trial.[NCT01555671]	Phase 4	250 participants (Actual)	Interventional	2012-01-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The period of time until the birth of the baby, since the patient being followed for delivery (NCT01555671)
Timeframe: 24h

The Duration of Active Phase of Labour

Intervention	minutes (Mean)
Meperidine Administration Group	24
Plasebo Group	27

The primary outcome is to evaluate whether meperidine is effective in shortening the duration of the active phase of labor (NCT01555671)
Timeframe: 24h

Total Duration of Labour

Intervention	minutes (Mean)
Meperidine Administration Group	249
Plasebo Group	304

Total time of delivery of patients who gave birth including the second stage of delivery (NCT01555671)
Timeframe: 24h

Article	Year
UTERINE CONTRACTILITY IN PRIMATES: A COMPARATIVE STUDY. Surgical forum, 1963, Volume: 14 Topics: Animals; Cyclopropanes; Diphenylacetic Acids; Ether; Female; Haplorhini; Humans; Magnesium; Meperidi	1963
IN VITRO AND IN VIVO EFFECTS OF SPARINE (PROMAZINE HYDROCHLORIDE) ON HUMAN UTERINE CONTRACTILITY. American journal of obstetrics and gynecology, 1964, Mar-15, Volume: 88 Topics: Female; Humans; In Vitro Techniques; Labor, Obstetric; Meperidine; Muscle Contraction; Pregnancy; Pr	1964
ACTION OF SUXAMETHONIUM ON PTOSIS DUE TO THIRD-NERVE PALSY. British medical journal, 1964, Oct-31, Volume: 2, Issue:5417 Topics: Aneurysm; Atropine; Blepharoptosis; Carotid Arteries; Contracture; Eyelids; Humans; Meperidine; Musc	1964
Effect of meperidine on uterine contractility during pregnancy and prelabor. American journal of obstetrics and gynecology, 1967, Apr-15, Volume: 97, Issue:8 Topics: Female; Fetal Death; Fetus; Heart Rate; Humans; Injections, Intravenous; Labor, Obstetric; Meperidin	1967
Analgesia in obstetrics. The effect of analgesia on uterine contractility and fetal heart rate. American journal of obstetrics and gynecology, 1967, Jul-15, Volume: 98, Issue:6 Topics: Adult; Anesthesia, Conduction; Anesthesia, Obstetrical; Autonomic Nerve Block; Female; Fetal Heart;	1967
Dual action of meperidine on the frog neuromuscular junction: a prejunctional, opiate receptor-mediated depression of transmitter release and a postjunctional, nonopiate receptor effect on the endplate. Archives internationales de pharmacodynamie et de therapie, 1981, Volume: 251, Issue:1 Topics: Acetylcholine; Action Potentials; Animals; Electric Stimulation; In Vitro Techniques; Meperidine; Mo	1981
Identification and localization of opioid receptors in the opossum lower esophageal sphincter. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:2 Topics: Animals; Esophagogastric Junction; Female; Male; Meperidine; Muscle Contraction; Naloxone; Narcotics	1983
Electromechanical coupling in rat basilar artery in response to morphine. Neurosurgery, 1983, Volume: 13, Issue:6 Topics: Animals; Basilar Artery; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Electric Con	1983
Myoneural effects of pethidine and droperidol. British journal of anaesthesia, 1984, Volume: 56, Issue:2 Topics: 4-Aminopyridine; Aminopyridines; Animals; Droperidol; Drug Interactions; Electric Stimulation; In Vi	1984
[Effect of dolantin and serotonin on the degree of perfusion tension in gestotic placenta]. Ginekologia polska, 1980, Volume: 51, Issue:12 Topics: Arteries; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Meperidine; Muscle	1980
[Effects of morphine, pethidine and fentanyl on isolated rabbit trachea]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1994, Volume: 15, Issue:5 Topics: Animals; Female; Fentanyl; In Vitro Techniques; Male; Meperidine; Morphine; Muscle Contraction; Musc	1994
Fentanyl and pethidine are antagonists on muscarinic receptors in guinea-pig ileum. Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:6 Topics: Animals; Binding, Competitive; Carbachol; Dose-Response Relationship, Drug; Fentanyl; Guinea Pigs; I	1993
Postoperative gastrointestinal electrical and mechanical activities in a patient with idiopathic intestinal pseudoobstruction. Gastroenterology, 1978, Volume: 74, Issue:1 Topics: Acetylcholine; Action Potentials; Atropine; Bethanechol Compounds; Carbachol; Electric Stimulation;	1978
Uptake and release of catecholamines in sympathetic nerve fibers in the spleen of the cod, Gadus morhua. European journal of pharmacology, 1976, Volume: 39, Issue:1 Topics: Acetylcholine; Animals; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-),	1976
Tetanic force development of adductor pollicis muscle in anesthetized man. Journal of applied physiology, 1975, Volume: 39, Issue:5 Topics: Adult; Aged; Anesthesia, General; Electric Stimulation; Humans; Male; Meperidine; Middle Aged; Muscl	1975
Differing effects of pethidine and morphine on human sphincter of Oddi motility. The British journal of surgery, 1990, Volume: 77, Issue:9 Topics: Adult; Aged; Atropine; Dose-Response Relationship, Drug; Female; Humans; Male; Manometry; Meperidine	1990
Different effects of morphine and pethidine on longitudinal and circular muscle tension of bovine coronary artery in vitro. Journal of cardiothoracic anesthesia, 1989, Volume: 3, Issue:5 Suppl 1 Topics: Animals; Cattle; Coronary Vessels; Endothelium, Vascular; Female; Male; Meperidine; Morphine; Muscle	1989
Effects of morphine and pethidine in vitro on longitudinal and circular muscle tension of bovine coronary artery. European journal of anaesthesiology, 1989, Volume: 6, Issue:5 Topics: Animals; Cattle; Coronary Vessels; In Vitro Techniques; Meperidine; Morphine; Muscle Contraction; Mu	1989
Mechanism for the opioid-induced twitch potentiations of frog's skeletal muscle. Canadian journal of physiology and pharmacology, 1986, Volume: 64, Issue:7 Topics: Animals; Calcium; Dextrorphan; Etorphine; In Vitro Techniques; Meperidine; Methadone; Morphine; Musc	1986
Opioid activity and distribution of fentanyl metabolites. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 334, Issue:3 Topics: Animals; Female; Fentanyl; Guinea Pigs; Ileum; Meperidine; Morphine; Muscle Contraction; Muscle, Smo	1986
Proceedings: Assessment of the agonist and antagonist activities of narcotic analgesic drugs by means of the mouse vas deferens. British journal of pharmacology, 1974, Volume: 51, Issue:1 Topics: Analgesics, Opioid; Animals; Codeine; Dose-Response Relationship, Drug; Electric Stimulation; Guinea	1974
Effects of pethidine and nalorphine on the mechanical and electrical activities of mammalian isolated ventricular muscle. British journal of pharmacology, 1972, Volume: 46, Issue:1 Topics: Action Potentials; Adenosine Triphosphatases; Animals; Cats; Guinea Pigs; Haplorhini; Heart; Heart V	1972
The effect of magnesium sulfate on anoxia and resuscitation in the neonate. American journal of obstetrics and gynecology, 1971, Feb-01, Volume: 109, Issue:3 Topics: Adrenal Medulla; Animals; Animals, Newborn; Asphyxia Neonatorum; Eclampsia; Female; Halothane; Heart	1971
Repetitive muscle depolarization from single indirect stimulation in anesthetized man. Journal of applied physiology, 1970, Volume: 28, Issue:4 Topics: Anesthetics; Cyclopropanes; Electric Stimulation; Electromyography; Ethers; Ethyl Ethers; Halothane;	1970
Effects of narcotic analgesics on contractions of the chick isolated, innervated oesophagus. The Journal of pharmacy and pharmacology, 1972, Volume: 24, Issue:9 Topics: Acetylcholine; Analgesics; Animals; Chickens; Cyclazocine; Dextropropoxyphene; Electric Stimulation;	1972
Massive initial prostaglandin impact in postconceptional therapy. Prostaglandins, 1972, Volume: 2, Issue:2 Topics: Abortion, Induced; Adult; Amniotic Fluid; Estradiol; Female; Humans; Hydroxyzine; Injections; Meperi	1972
Experience with Shirodkar's operation and postoperative alcohol treatment. Acta obstetricia et gynecologica Scandinavica, 1973, Volume: 52, Issue:1 Topics: Abortion, Threatened; Amobarbital; Delivery, Obstetric; Ethanol; Female; Fetal Death; Gestational Ag	1973
An experimental model for evaluating drug effects on the ureter. British journal of urology, 1973, Volume: 45, Issue:1 Topics: Animals; Dogs; Female; Histamine; Isoproterenol; Kidney; Meperidine; Methods; Models, Biological; Mo	1973
Human eye movements following horizontal rectus muscle disinsertion. Archives of ophthalmology (Chicago, Ill. : 1960), 1973, Volume: 90, Issue:4 Topics: Electrooculography; Eye Movements; Humans; Male; Meperidine; Methods; Middle Aged; Muscle Contractio	1973
Contractile responses to morphine, piritramide, meperidine, and fentanyl: a comparative study of effects on the isolated ventricular myocardium. Anesthesiology, 1972, Volume: 37, Issue:3 Topics: Analgesics; Animals; Biomechanical Phenomena; Cats; Electric Stimulation; Fentanyl; Heart Ventricles	1972
[Pharmacological studies of a new analgesic, 1-(m-methoxyphenyl)-2-dimethylaminomethylcyclohexanol(1) hydrochloride (K-315). 1. Analgesic effects and general pharmacological action]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:1 Topics: Action Potentials; Alcohols; Aminopyrine; Analgesics; Animals; Antitussive Agents; Blood Pressure; B	1972
Comparison of effect of morphine-like analgesics on transmurally stimulated guinea-pig ileum. British journal of pharmacology, 1969, Volume: 37, Issue:2 Topics: Analgesics; Animals; Codeine; Cyclic N-Oxides; Drug Tolerance; Electric Stimulation; Female; Fentany	1969
Effect of meperidine on uterine contractility. American journal of obstetrics and gynecology, 1969, Dec-01, Volume: 105, Issue:7 Topics: Female; Humans; Labor, Induced; Labor, Obstetric; Meperidine; Muscle Contraction; Pregnancy; Uterus	1969
Effect of meperidine on uterine contractility. American journal of obstetrics and gynecology, 1970, Aug-15, Volume: 107, Issue:8 Topics: Female; Humans; Meperidine; Muscle Contraction; Uterus	1970
[Effect of promethazine on uterine contractions]. Harefuah, 1970, Jan-15, Volume: 78, Issue:2 Topics: Drug Antagonism; Drug Synergism; Female; Humans; Labor, Obstetric; Meperidine; Muscle Contraction; O	1970
[The effects of spasmolytics on the mechanical and electrical activity of isolated rat uterus]. Arzneimittel-Forschung, 1967, Volume: 17, Issue:7 Topics: Acetylcholine; Action Potentials; Animals; Depression, Chemical; Female; In Vitro Techniques; Meperi	1967
The role of potassium in ureteral physiology and pharmacology. Investigative urology, 1968, Volume: 6, Issue:2 Topics: Action Potentials; Animals; Diphenhydramine; Dogs; Epinephrine; Female; Histamine; Isoproterenol; Me	1968

meperidine and Muscle Contraction