meperidine has been researched along with Liver Cirrhosis in 7 studies
Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of moderate cirrhosis on the bioavailability and systemic clearance of three model analgesic compounds (pethidine, pentazocine, and salicylamide) with substantial first-pass metabolism was examined in 8 cirrhotic subjects and 4 agematched healthy controls." | 1.26 | Enhanced bioavailability and decreased clearance of analgesics in patients with cirrhosis. ( Blaschke, TF; Gregory, PB; Meffin, PJ; Neal, EA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weston, BR | 1 |
| Chadalawada, V | 1 |
| Chalasani, N | 1 |
| Kwo, P | 1 |
| Overley, CA | 1 |
| Symms, M | 1 |
| Strahl, E | 1 |
| Rex, DK | 1 |
| Schenker, S | 3 |
| Hoyumpa, AM | 1 |
| Wilkinson, GR | 2 |
| Neal, EA | 1 |
| Meffin, PJ | 1 |
| Gregory, PB | 1 |
| Blaschke, TF | 1 |
| Klotz, U | 2 |
| McHorse, TS | 2 |
| Wilkinson, G | 1 |
| Melikian, V | 1 |
| Eddy, JD | 1 |
| Paton, A | 1 |
| Lippmann, M | 1 |
| Lorhan, PH | 1 |
1 review available for meperidine and Liver Cirrhosis
| Article | Year |
|---|---|
The effect of parenchymal liver disease on the disposition and elimination of sedatives and analgesics.
Topics: Analgesics; Anti-Anxiety Agents; Barbiturates; Diazepam; Half-Life; Hepatitis; Humans; Hypnotics and | 1975 |
1 trial available for meperidine and Liver Cirrhosis
| Article | Year |
|---|---|
Nurse-administered propofol versus midazolam and meperidine for upper endoscopy in cirrhotic patients.
Topics: Aged; Ambulatory Care; Chronic Disease; Conscious Sedation; Dose-Response Relationship, Drug; Drug A | 2003 |
5 other studies available for meperidine and Liver Cirrhosis
| Article | Year |
|---|---|
Enhanced bioavailability and decreased clearance of analgesics in patients with cirrhosis.
Topics: Adult; Biological Availability; Half-Life; Humans; Liver; Liver Circulation; Liver Cirrhosis; Liver | 1979 |
The effect of cirrhosis on the disposition and elimination of meperidine in man.
Topics: Adult; Chromatography, Gas; Half-Life; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; | 1974 |
Impaired elimination of meperidine in patients with liver disease.
Topics: Acute Disease; Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Biotransformatio | 1974 |
The stimulant effect of drugs on indocyanine green clearance by the liver.
Topics: Adult; Aged; Anticonvulsants; Densitometry; Drug Therapy; Ear, External; Female; Half-Life; Haloperi | 1972 |
Anesthetic management of the patient with portacaval shunts.
Topics: Adult; Aged; Anesthesia, General; Blood Volume; Esophageal and Gastric Varices; Female; Gastrointest | 1968 |