meperidine has been researched along with HbS Disease in 39 studies
Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if a single dose of intramuscular ketorolac given on presentation to the emergency department has a narcotic-sparing effect in adult patients with sickle cell vaso-occlusive crisis pain." | 9.07 | Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992) |
| "Reports of seizures associated with meperidine have led to a growing reliance on intravenous morphine, usually with patient-controlled devices." | 5.30 | Low frequency of meperidine-associated seizures in sickle cell disease. ( Nadvi, SZ; Ravindranath, Y; Sarnaik, S, 1999) |
| "To determine if a single dose of intramuscular ketorolac given on presentation to the emergency department has a narcotic-sparing effect in adult patients with sickle cell vaso-occlusive crisis pain." | 5.07 | Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992) |
| "Reports of seizures associated with meperidine have led to a growing reliance on intravenous morphine, usually with patient-controlled devices." | 1.30 | Low frequency of meperidine-associated seizures in sickle cell disease. ( Nadvi, SZ; Ravindranath, Y; Sarnaik, S, 1999) |
| "Four patients had generalized seizures only with meperidine administration, all of whom had nonfocal EEG and radiological studies." | 1.29 | The spectrum of epilepsy in sickle cell anemia. ( Ballas, SK; Gzesh, DJ; Liu, JE, 1994) |
| "The gene for sickle cell disease is carried by 8% of the African-American population in the United States." | 1.28 | Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992) |
| " Patients number 8 through 16 gave higher ratings probably because a more idealized dosage regimen was being used by that time in the study." | 1.28 | Patient-controlled analgesia in patients with sickle cell vaso-occlusive crisis. ( Castro, O; Finke, H; McPherson, E; Perlin, E; Pittman, J, 1990) |
| " Patients given continuous infusions required more narcotic to control their pain and had more side effects than those treated with bolus injections alone, suggesting a dose-response relationship between narcotic dose and several known side effects." | 1.27 | Intravenous narcotic therapy for children with severe sickle cell pain crisis. ( Buchanan, GR; Cole, TB; Smith, SJ; Sprinkle, RH, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (20.51) | 18.7374 |
| 1990's | 23 (58.97) | 18.2507 |
| 2000's | 7 (17.95) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Phillips, WJ | 1 |
| Jones, J | 1 |
| McCarter, J | 1 |
| Uzun, B | 1 |
| Kekec, Z | 1 |
| Gurkan, E | 1 |
| Perlman, KM | 1 |
| Myers-Phariss, S | 1 |
| Rhodes, JC | 1 |
| Charles, KS | 1 |
| Osagie, K | 1 |
| Battini, RK | 1 |
| Morgan, MT | 1 |
| Howland, MA | 1 |
| Goldfrank, LR | 1 |
| Ballas, SK | 3 |
| Perlin, E | 2 |
| Finke, H | 2 |
| Castro, O | 2 |
| Rana, S | 1 |
| Pittman, J | 2 |
| Burt, R | 1 |
| Ruff, C | 1 |
| McHugh, D | 1 |
| Yang, YM | 1 |
| Hoff, C | 1 |
| Hamm, C | 1 |
| Mankad, V | 1 |
| Boerth, RC | 1 |
| Friedrich, L | 1 |
| Liu, JE | 1 |
| Gzesh, DJ | 1 |
| Richardson, P | 2 |
| Steingart, R | 2 |
| Ward, SJ | 1 |
| Simini, B | 1 |
| Forbes, K | 1 |
| Hanks, GW | 1 |
| Justins, DM | 1 |
| Cherry, DA | 1 |
| Meltzer, BA | 1 |
| Fertleman, CR | 1 |
| Gallagher, A | 1 |
| Rossiter, MA | 1 |
| Daggett, P | 1 |
| Agble, YM | 1 |
| D'Sa, S | 1 |
| Parker, N | 1 |
| Clare, N | 1 |
| Nadvi, SZ | 1 |
| Sarnaik, S | 1 |
| Ravindranath, Y | 1 |
| Sanders, DY | 1 |
| Severance, HW | 1 |
| Pollack, CV | 1 |
| Pegelow, CH | 1 |
| Walson, PD | 1 |
| Harrison, JF | 1 |
| Liesner, R | 1 |
| Davies, SC | 1 |
| Wright, SW | 1 |
| Norris, RL | 1 |
| Mitchell, TR | 1 |
| Longenecker, GL | 1 |
| Beyers, BJ | 1 |
| Mankad, VN | 1 |
| Pryle, BJ | 1 |
| Grech, H | 1 |
| Stoddart, PA | 1 |
| Carson, R | 1 |
| O'Mahoney, T | 1 |
| Reynolds, F | 1 |
| McPherson, E | 1 |
| Friedman, EW | 1 |
| Webber, AB | 1 |
| Osborn, HH | 1 |
| Schwartz, S | 1 |
| Cole, TB | 1 |
| Sprinkle, RH | 1 |
| Smith, SJ | 1 |
| Buchanan, GR | 1 |
| Venkataraman, M | 1 |
| Westerman, MP | 1 |
| Abbuhl, S | 1 |
| Jacobson, S | 1 |
| Murphy, JG | 1 |
| Gibson, G | 1 |
| Schreiner, J | 1 |
| Marx, GF | 1 |
| Karayalcin, G | 1 |
| Imran, M | 1 |
| Rosner, F | 1 |
| Bellina, JH | 1 |
| Bickers, JN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887] | Phase 2 | 150 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days
| Intervention | Days (Median) |
|---|---|
| Inhaled Nitric Oxide | 4.06 |
| Placebo | 3.11 |
(NCT00094887)
Timeframe: within 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 5 |
| Placebo | 7 |
Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 8 |
| Placebo | 7 |
"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days
| Intervention | Hours (Median) |
|---|---|
| Inhaled Nitric Oxide | 61.83 |
| Placebo | 55.16 |
The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| during first 24 hours | during 30-day follow-up | |
| Inhaled Nitric Oxide | 0 | 9 |
| Placebo | 0 | 17 |
The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days
| Intervention | mg (Median) | |
|---|---|---|
| within 8 hours | within 40 days | |
| Inhaled Nitric Oxide | 16.25 | 153.75 |
| Placebo | 17.25 | 211.37 |
3 trials available for meperidine and HbS Disease
| Article | Year |
|---|---|
Efficacy of tramadol vs meperidine in vasoocclusive sickle cell crisis.
Topics: Acute Disease; Analgesics, Opioid; Anemia, Sickle Cell; Blood Pressure; Emergency Service, Hospital; | 2010 |
Enhancement of pain control with ketorolac tromethamine in patients with sickle cell vaso-occlusive crisis.
Topics: Adult; Analgesics; Anemia, Sickle Cell; Constriction, Pathologic; Digestive System Diseases; Double- | 1994 |
Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect.
Topics: Acute Disease; Adult; Analgesics; Anemia, Sickle Cell; Double-Blind Method; Emergencies; Female; Hum | 1992 |
36 other studies available for meperidine and HbS Disease
| Article | Year |
|---|---|
Meperidine for acute sickle cell crisis: what is the rationale?
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Humans; Meperidine; Pain | 2008 |
A shift from demerol (meperidine) to dilaudid (hydromorphone) improves pain control and decreases admissions for patients in sickle cell crisis.
Topics: Anemia, Sickle Cell; Clinical Protocols; Emergency Service, Hospital; Humans; Hydromorphone; Meperid | 2004 |
Hospital admissions for acute painful crisis in Trinidad and Tobago. Are the British Committee for Standards in Haematology (BCSH) guidelines applicable?
Topics: Adolescent; Adult; Analgesics, Opioid; Anemia, Sickle Cell; Female; Guideline Adherence; Hospitaliza | 2006 |
Use of meperidine as the analgesic of choice in treating pain from acute painful sickle cell crisis.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Humans; Meperidine; Pain | 2008 |
Why meperidine should not make a comeback in treating patients with sickle cell disease.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Humans; Meperidine; Pain | 2008 |
Meperidine for acute sickle cell pain in the emergency department: revisited controversy.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Emergency Service, Hospital; Half-Life; Humans; Meperidine; | 2008 |
Pharmacokinetics of meperidine in sickle cell patients.
Topics: Anemia, Sickle Cell; Humans; Meperidine | 1995 |
The spectrum of epilepsy in sickle cell anemia.
Topics: Adult; Anemia, Sickle Cell; Brain; Electroencephalography; Epilepsy; Female; Humans; Magnetic Resona | 1994 |
Acute-phase response and sickle crisis.
Topics: Acute-Phase Reaction; Anemia, Sickle Cell; Humans; Meperidine; Pain | 1993 |
Meperidine and ketorolac in the treatment of painful sickle cell crisis.
Topics: Analgesics; Anemia, Sickle Cell; Humans; Ketorolac; Meperidine; Pain; Tolmetin | 1993 |
Sickle cell pain crisis.
Topics: Analgesia; Analgesia, Patient-Controlled; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Meperidin | 1996 |
Sickle cell pain crisis.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Humans; Meperidine; Morphine; Pain | 1996 |
Sickle cell pain crisis.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Humans; Meperidine; Morphine; Pain | 1996 |
Sickle cell pain crisis.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Contraindications; Humans; Meperidine; Pain; Practice Guide | 1996 |
Evaluation of fast track admission policy for children with sickle cell crises: questionnaire survey of parents' preferences.
Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Child; Child, Preschool; Decision Making; Emerg | 1997 |
Fast track admission for children with sickle cell crises. Should morphine or pethidine be given?
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Child; Child, Preschool; Humans; Meperidine; Morphine | 1998 |
Management of sickle cell disease. Non-addictive analgesics can be as effective as morphine and pethidine.
Topics: Acetaminophen; Analgesics, Opioid; Anemia, Sickle Cell; Child; Child, Preschool; Codeine; Drug Combi | 1998 |
Fast track admission for children with sickle cell crises. Opiates other than pethidine are better.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Child; Child, Preschool; Decision Making; Humans; Meperidin | 1998 |
Management of sickle cell disease. Management would improve if doctors listened more to patients.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Communication; Humans; Infusions, Intravenous; Meperidine; | 1998 |
Low frequency of meperidine-associated seizures in sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Female; Humans; Infant; Infant, Newborn; Injections, Intravenous; M | 1999 |
Treatment of painful sickle cell leg ulcers with topical opioids.
Topics: Administration, Topical; Adult; Aged; Anemia, Sickle Cell; Female; Humans; Leg Ulcer; Meperidine; Na | 2002 |
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory | 1992 |
Survey of pain management therapy provided for children with sickle cell disease.
Topics: Acetaminophen; Analgesics; Anemia, Sickle Cell; Child; Child, Preschool; Codeine; Drug Administratio | 1992 |
Neurologic abnormalities in sickle cell disease: role of meperidine.
Topics: Anemia, Sickle Cell; Child; Humans; Meperidine; Nervous System Diseases | 1992 |
Pethidine in sickle cell crisis.
Topics: Anemia, Sickle Cell; Humans; Meperidine; Pain | 1992 |
Platelet regulatory prostanoids and platelet release products in sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Aspirin; beta-Thromboglobulin; Blood Platelets; Epoprostenol; Human | 1992 |
Toxicity of norpethidine in sickle cell crisis.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Cholinesterase Inhibitors; Female; Humans; Male; Meperidine; | 1992 |
Patient-controlled analgesia in patients with sickle cell vaso-occlusive crisis.
Topics: Adult; Analgesia; Anemia, Sickle Cell; Female; Humans; Hydroxyzine; Infusion Pumps; Male; Meperidine | 1990 |
Oral analgesia for treatment of painful crisis in sickle cell anemia.
Topics: Administration, Oral; Adult; Anemia, Sickle Cell; Emergencies; Emergency Service, Hospital; Female; | 1986 |
Intravenous narcotic therapy for children with severe sickle cell pain crisis.
Topics: Adolescent; Anemia, Sickle Cell; Child; Female; Humans; Infusions, Intravenous; Male; Meperidine; Mo | 1986 |
Meperidine usage in patients with sickle cell crisis.
Topics: Anemia, Sickle Cell; Humans; Meperidine; Pain | 1986 |
B-cell changes occur in patients with sickle cell anemia.
Topics: Adult; Anemia, Sickle Cell; Antibodies, Monoclonal; B-Lymphocytes; Hemolytic Plaque Technique; Human | 1985 |
Serum concentrations of meperidine in patients with sickle cell crisis.
Topics: Absorption; Adult; Anemia, Sickle Cell; Body Weight; Chromatography, Gas; Female; Humans; Injections | 1986 |
[Obstetrical anaesthesia in sickle cell haemopathia (author's transl)].
Topics: Anemia, Sickle Cell; Anesthesia, Intravenous; Anesthesia, Obstetrical; Anesthetics; Black People; Cy | 1974 |
Priapism in sickle cell disease: report of five cases.
Topics: Adult; Anemia, Sickle Cell; Blood Transfusion; Chlorpromazine; Codeine; Diethylstilbestrol; Drainage | 1972 |
Modern management of sickle cell disease in pregnancy.
Topics: Abortion, Spontaneous; Anemia, Sickle Cell; Black or African American; Blood Transfusion; Blood Visc | 1974 |