meperidine and Emesis, Postoperative

meperidine has been researched along with Emesis, Postoperative in 30 studies

Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.

Research

Studies (30)

Authors

Clinical Trials (9)

Trial Overview

Trial Outcomes

Median Pain Score During Shift 1, as Measured With the Face, Legs, Activity, Cry, Consolability Scale

Pain is measured with the Face, Legs, Activity, Cry, Consolability scale (FLACC) is a measurement used to assess pain for children between the ages of 2 months and 7 years or individuals that are unable to communicate their pain. The scale is scored in a range of 0-10 with 0 representing no pain. The median pain score over the first shift (24 hours) is reported. (NCT00743730)
Timeframe: First 24 hours on study

Number of Patients Requiring Naloxone for Respiratory Depression

Number of patients requiring naloxone for respiratory depression (our most important side effect) (NCT00743730)
Timeframe: Daily, for up to 3 days

Parent Satisfaction With the Administration Technique

"Parents were asked Overall, how satisfied were you with the pain relief your child received after surgery? Response options were: 1. Very Dissatisfied, 2. Dissatisfied, 3. Satisfied, 4. Very Satisfied. Responses were scored on a 1-4 scale, with Very Dissatisfied = 1; Dissatisfied = 2; Satisfied = 3; Very Satisfied = 4." (NCT00743730)
Timeframe: parents, once at the end of study

Intensive Care Delirium Screening Checklist (ICDSC)

Number of patients who score greater than a 4 on the 0-8 point ICDSC scale to assess delirium scores. 8 separate levels of signs for delirium assessed (1. altered level of consciousness, 2. inattention, 3. disorientation, 4. hallucination, delusion, or psychosis, 5. psychomotor agitation or retardation, 6. inappropriate speech or mood, 7. sleep-wake cycle disturbance, 8. symptom fluctuation), with 0 points awarded when patient does not exhibit above signs of delirium and 1 point awarded per confirmed sign of delirium. Score then totaled, 0 = normal, 1-3 = subsyndromal delirium, 4-8 = delirium. (NCT03198871)
Timeframe: The delirium scores will first be measured every 12 hours for 72 hours after surgery.

Number of Participants With Readmission to the Hospital

If the patient is readmitted to the hospital after being fully discharged, the event will be recorded. (NCT03198871)
Timeframe: From the time of consent until 30 days post-operatively

Postoperative Pain Intensity

Number of patients with unsatisfactory pain relief defined as average numeric rating scale (NRS) more than 5 will be compared between the two groups. This may include patients using IVPCA for pain relief during the first 48 hours postoperative. (NCT03198871)
Timeframe: PACU admission every thirty minutes until discharge to the floor and thereafter every four hours for first 24-hour, then every six hours until 48 hours and then every twelve hours until 72 hours postoperatively.

Time to Ambulation

The time it takes for the patient to successfully ambulate post-surgery will be measured. (NCT03198871)
Timeframe: From date of PACU admission until the date of first documented ambulation, assessed up to 72 hours postoperatively

Time to Bowel Movement

The time it takes for the first bowel movement postoperatively will be measured. (NCT03198871)
Timeframe: From time patient left operating room until the time of first documented bowel movement, assessed up to hospital discharge

Time to Hospital Discharge

The time it takes for the patient to be fully discharged from the hospital post-surgery will be measured. (NCT03198871)
Timeframe: From date of randomization until the date of hospital discharge or 30 days postoperatively, whichever comes first

Time to Oral Intake

The time it takes for the patient to ingest orally post-surgery will be measured. (NCT03198871)
Timeframe: From date of randomization until the date of first documented oral intake, assessed up to 72 hours postoperatively

Time to Readiness for Discharge From Post Anesthesia Care Unit (PACU)

The time from PACU admission to PACU discharge to the floor will be measured. (NCT03198871)
Timeframe: From time of PACU admission until the time of discharge, assessed up to 24 hours postoperatively

Patient Satisfaction

Overall patient satisfaction as well as satisfaction relating to pain management and cost analyses will be measured. These will be measured with a numerical rating scale (NRS) with 0- being worst satisfaction and 10 - best satisfaction. (NCT03198871)
Timeframe: These measurements will be taken at time of discharge up to 30 days, whichever comes first

Post-operative Emesis

Frequency of emesis and rescue antiemetic requirement will be documented (NCT03198871)
Timeframe: These will be evaluated from the time of PACU admission until 72 hours postoperatively.

Post-operative Nausea

Nausea will be evaluated by nausea score from 0 to 10, with 0 equaling no nausea and 10 equaling the worst nausea imaginable. (NCT03198871)
Timeframe: These will be evaluated from the time of PACU admission until 72 hours postoperatively.

SF-12 Health Survey

Survey to assess patient's overall health (via a combination of mental and physical health assessment) at 30 days post-discharge. Two summary scores are reported from the SF-12 - a mental component score (MCS-12) and a physical component score (PCS-12). The scores may be reported as Z-scores (difference compared to the population average, measured in standard deviations). The United States population average PCS-12 and MCS-12 are both 50 points. The United States population standard deviation is 10 points. So each 10 increment of 10 points above or below 50, corresponds to one standard deviation away from the average (NCT03198871)
Timeframe: These measurements will take place at 30-days post hospital discharge

Total Post-operative Narcotic Consumption

Rescue analgesia will be given according to institutional pain management protocol. Unit of Measure recorded as OME (Oral Morphine Equivalent) consumption in mg. (NCT03198871)
Timeframe: From time of PACU admission until the time of discharge and 72-hours postoperatively, whichever comes first

Reviews

2 reviews available for meperidine and Emesis, Postoperative

Trials

24 trials available for meperidine and Emesis, Postoperative

Other Studies

4 other studies available for meperidine and Emesis, Postoperative