meperidine has been researched along with Disease Models, Animal in 11 studies
Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Morphine, pethidine and fentanyl, which showed a biphasic dose-response relationship with respect to seizure modulation, abolished the anticonvulsant activity of propofol to exhibit their own intrinsic activity in proconvulsant doses." | 5.29 | Interactions between opioid drugs and propofol in laboratory models of seizures. ( Ahmad, I; Pleuvry, BJ, 1995) |
| " The analgesic activity was examined against oxytocin-induced dysmenorrhea in mice." | 3.78 | Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. ( Chen, T; Duan, JA; Gu, W; Hua, Y; Jiang, H; Su, S; Tang, Y; Wang, Y; Zhou, W, 2012) |
| " The anticonvulsant activity of F1,6BP was determined in rat models of acute seizures induced by pilocarpine, kainic acid, or pentylenetetrazole." | 3.74 | Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats. ( Khan, FA; Lian, XY; Stringer, JL, 2007) |
| "The latency and incidence of seizures were recorded by an observer who was uninformed of the estrous cycle and dietary treatment conditions of the rats." | 1.33 | Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. ( Frye, CA; Harney, JP; Rhodes, ME; Talluri, J, 2005) |
| " Morphine, pethidine and fentanyl, which showed a biphasic dose-response relationship with respect to seizure modulation, abolished the anticonvulsant activity of propofol to exhibit their own intrinsic activity in proconvulsant doses." | 1.29 | Interactions between opioid drugs and propofol in laboratory models of seizures. ( Ahmad, I; Pleuvry, BJ, 1995) |
| "Xylazine was significantly more effective in obtunding deep pain (P less than 0." | 1.26 | Objective tests of analgesic drugs in ponies. ( Lumb, WV; Pippi, NL, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peştean, C | 1 |
| Taulescu, M | 1 |
| Ober, C | 1 |
| Cătoi, C | 1 |
| Miclăuş, V | 1 |
| Oana, L | 1 |
| Bodolea, C | 1 |
| Fox, MA | 1 |
| Jensen, CL | 1 |
| Murphy, DL | 1 |
| Su, S | 1 |
| Hua, Y | 1 |
| Wang, Y | 1 |
| Gu, W | 1 |
| Zhou, W | 1 |
| Duan, JA | 1 |
| Jiang, H | 1 |
| Chen, T | 1 |
| Tang, Y | 1 |
| Rhodes, ME | 1 |
| Talluri, J | 1 |
| Harney, JP | 1 |
| Frye, CA | 1 |
| Fu, CY | 1 |
| Tang, XL | 1 |
| Yang, Q | 1 |
| Chen, Q | 1 |
| Wang, R | 1 |
| Lian, XY | 1 |
| Khan, FA | 1 |
| Stringer, JL | 1 |
| Alreja, M | 1 |
| Mutalik, P | 1 |
| Nayar, U | 1 |
| Manchanda, SK | 1 |
| Suzuki, T | 1 |
| Yoshii, T | 1 |
| Yanaura, S | 1 |
| Ahmad, I | 1 |
| Pleuvry, BJ | 1 |
| Pippi, NL | 1 |
| Lumb, WV | 1 |
| Baum, T | 1 |
| Eckfeld, DK | 1 |
| Shropshire, AT | 1 |
| Rowles, G | 1 |
| Varner, LL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Randomized, Open-label, Controlled Trial to Assess Effectiveness and Safety of Rhea Health Tone® as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia[NCT04627519] | 85 participants (Actual) | Interventional | 2020-12-09 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for meperidine and Disease Models, Animal
| Article | Year |
|---|---|
The effect of chronic toxicity of pethidine on the spinal cord: an experimental model in rabbits.
Topics: Adjuvants, Anesthesia; Animals; Disease Models, Animal; Humans; Male; Meperidine; Rabbits; Random Al | 2013 |
Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Behavioral Symptoms; Disease Mo | 2009 |
Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Boswellia; Carrageenan; Chromatography, Liquid; Commi | 2012 |
Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats.
Topics: Allylamine; Analysis of Variance; Animals; Animals, Newborn; Diet; Disease Models, Animal; Drug Comb | 2005 |
Effects of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on the antinociceptive activity of pethidine administered at the peripheral and supraspinal level.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Re | 2007 |
Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats.
Topics: Acute Disease; Allylamine; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Deoxygl | 2007 |
The formalin test: a tonic pain model in the primate.
Topics: Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Female; Formaldehyde; Hand; Maca | 1984 |
[Assessment of morphine-type physical dependence liability in mice using the drug-admixed food method].
Topics: Administration, Oral; Animals; Codeine; Disease Models, Animal; Humans; Male; Meperidine; Mice; Mice | 1984 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; | 1995 |
Objective tests of analgesic drugs in ponies.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Fentanyl; Horse Diseases; Horses; Male; Meperid | 1979 |
Observations on models used for the evaluation of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutte | 1971 |