meperidine has been researched along with Cancer of Cervix in 2 studies
Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thanthong, S | 1 |
| Rojthamarat, S | 1 |
| Worasawate, W | 1 |
| Vichitvejpaisal, P | 1 |
| Nantajit, D | 1 |
| Ieumwananontachai, N | 1 |
| Dai, YH | 1 |
| Ou, KL | 1 |
| Chu, PW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Meperidine and Fentanyl on Pain Scale and Quality of Life in Cervical Cancer Patients Receiving Brachytherapy: A Double-blind, Randomized Controlled Trial[NCT02684942] | Phase 4 | 40 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Sum of fentanyl dose when finish each fraction of brachytherapy (NCT02684942)
Timeframe: after complete treatment.
| Intervention | ug. (Mean) |
|---|---|
| Fentanyl | 100.18 |
Sum of meperidine dose when finish each fraction of brachytherapy (NCT02684942)
Timeframe: after complete treatment.
| Intervention | mg. (Mean) |
|---|---|
| Meperidine | 50.13 |
Size of ovoids that a pair part of brachytherapy applicator insert in vagina trough cervix. (NCT02684942)
Timeframe: after complete applicator insertion.
| Intervention | Centimeter (Median) |
|---|---|
| Meperidine | 2 |
| Fentanyl | 2 |
Size of tumor at cervix measured by the doctor before insert applicator. (NCT02684942)
Timeframe: Before insert applicator in each fraction of brachytherapy.
| Intervention | CM. (Mean) |
|---|---|
| Meperidine | 2.23 |
| Fentanyl | 2.21 |
Perceived pain score according to standard 10-cm visual analog scales (VAS) was assessed before injection of medicine for every 15 minutes up to 120 minutes.The minimum and maximum scores were 0, 10. Score 0 means no pain, 1-3 mild pain, 4-6 moderate pain, 7-9 severe pain and 10 worst pain. (NCT02684942)
Timeframe: From date of the first fraction until date of the last fraction of brachytherapy, once a week for four weeks
| Intervention | units on a scale (Mean) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| baseline | 0 minute | 15 minute | 30 minute | 45 minute | 60 minute | 75 minute | 90 minute | 105 minute | 120 minute | |
| Fentanyl | 0.14 | 0.40 | 0.65 | 1.24 | 1.70 | 0.81 | 0.53 | 0.13 | 0.13 | 0.13 |
| Meperidine | 0.04 | 0.49 | 0.59 | 1.05 | 1.33 | 0.61 | 0.49 | 0.24 | 0.24 | 0.24 |
Perceived Quality of life (EQ-5D) was assessed before the first brachytherpy and immediately after completion of each of the 4 brachytherapy fractions. The EQ-5D have 5 dimensions: mobility, self-care, usual activities, topics each content 3 responses: no problems, some problems, extreme problems. (NCT02684942)
Timeframe: From date of the first fraction of brachytherapy until date of the last fraction of brachytherapy,once a week for 4 weeks
| Intervention | participants (Number) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No problems in mobility | Some problems in mobility | Severe problems in mobility | No problem in self-care | Some problem in self-care | Severe problem in self-care | No problem in usual activities | Some problem in usual activities | Severe problem in usual activities | No problem in pain/discomfort | Some problem in pain/discomfort | Severe problem in pain/discomfort | No problem in anxiety/depression | Some problem in anxiety/depression | Severe problem in anxiety/depression | |
| Fentanyl | 58 | 18 | 1 | 69 | 6 | 2 | 53 | 21 | 3 | 23 | 53 | 1 | 42 | 33 | 2 |
| Meperidine | 62 | 16 | 1 | 68 | 11 | 0 | 55 | 22 | 2 | 27 | 49 | 3 | 46 | 32 | 1 |
1 trial available for meperidine and Cancer of Cervix
| Article | Year |
|---|---|
Comparison of efficacy of meperidine and fentanyl in terms of pain management and quality of life in patients with cervical cancer receiving intracavitary brachytherapy: a double-blind, randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Brachytherapy; Double-Blind Method; Female; Fent | 2017 |
1 other study available for meperidine and Cancer of Cervix
| Article | Year |
|---|---|
Cerebellar and oculomotor dysfunction induced by rapid infusion of pethidine.
Topics: Adult; Analgesics, Opioid; Carcinoma, Squamous Cell; Cerebellar Ataxia; Dysarthria; Female; Humans; | 2014 |