meperidine has been researched along with Apoplexy in 5 studies
Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van der Worp, HB | 2 |
| Macleod, MR | 2 |
| Bath, PM | 1 |
| Demotes, J | 1 |
| Durand-Zaleski, I | 1 |
| Gebhardt, B | 1 |
| Gluud, C | 1 |
| Kollmar, R | 2 |
| Krieger, DW | 1 |
| Lees, KR | 1 |
| Molina, C | 1 |
| Montaner, J | 1 |
| Roine, RO | 1 |
| Petersson, J | 1 |
| Staykov, D | 1 |
| Szabo, I | 1 |
| Wardlaw, JM | 1 |
| Schwab, S | 2 |
| Schellinger, PD | 1 |
| Steigleder, T | 1 |
| Köhrmann, M | 1 |
| Lyden, P | 1 |
| Ernstrom, K | 1 |
| Cruz-Flores, S | 1 |
| Gomes, J | 1 |
| Grotta, J | 1 |
| Mullin, A | 1 |
| Rapp, K | 1 |
| Raman, R | 1 |
| Wijman, C | 1 |
| Hemmen, T | 1 |
| Sena, ES | 1 |
| Jeffreys, AL | 1 |
| Cox, SF | 1 |
| Sastra, SA | 1 |
| Churilov, L | 1 |
| Rewell, S | 1 |
| Batchelor, PE | 1 |
| Howells, DW | 1 |
| Kammersgaard, LP | 1 |
| Rasmussen, BH | 1 |
| Jørgensen, HS | 1 |
| Reith, J | 1 |
| Weber, U | 1 |
| Olsen, TS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| EuroHYP-1: European Multicentre, Randomised, Phase III Clinical Trial of Therapeutic Hypothermia Plus Best Medical Treatment Versus Best Medical Treatment Alone for Acute Ischaemic Stroke[NCT01833312] | Phase 3 | 98 participants (Actual) | Interventional | 2013-07-31 | Terminated (stopped due to Slow recruitment, cessation of funding) | ||
| Phase 2/3 Study of Intravenous Thrombolysis and Hypothermia for Acute Treatment of Ischemic Stroke[NCT01123161] | Phase 2/Phase 3 | 120 participants (Actual) | Interventional | 2010-06-30 | Terminated (stopped due to The ICTuS 2 portion of the trial has been halted and data will be analyzed.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mortality prior to the 90-day evaluation. (NCT01123161)
Timeframe: 90 days
| Intervention | participants (Number) |
|---|---|
| Group1: IV t-PA and Normothermia | 5 |
| Group 2 : IV t-PA and Hypothermia and Anti-shivering Treatment | 10 |
Incidence (number) of any intracranial hemorrhage (ICH) (whether or not symptomatic) within 48 hours of stroke onset will be presented by treatment group and overall. (NCT01123161)
Timeframe: 48 hours
| Intervention | participants (Number) |
|---|---|
| Group1: IV t-PA and Normothermia | 13 |
| Group 2 : IV t-PA and Hypothermia and Anti-shivering Treatment | 9 |
Incidence (number) of Symptomatic ICH (sICH) within 48 hours of stroke onset will be presented by treatment group and overall. Patients with neuroworsening (4 or more point increase in NIHSS , or a decline in the NIHSS consciousness item 1A score of more than 1 point, or a motor deterioration lasting more than 8 hours, all not due to iatrogenic cause) and hemorrhage seen on brain images in whom the investigator attributes the clinical change to the hemorrhage. (NCT01123161)
Timeframe: 48 hours
| Intervention | participants (Number) |
|---|---|
| Group1: IV t-PA and Normothermia | 2 |
| Group 2 : IV t-PA and Hypothermia and Anti-shivering Treatment | 1 |
Number subjects diagnosed with pneumonia according to CDC criteria will be presented by treatment group and overall, regardless of seriousness (NCT01123161)
Timeframe: 7 days or discharge whichever comes first
| Intervention | participants (Number) |
|---|---|
| Group1: IV t-PA and Normothermia | 6 |
| Group 2 : IV t-PA and Hypothermia and Anti-shivering Treatment | 12 |
The National Institutes of Health Stroke Scale (NIHSS) is used to quantify neurological deficit. The scale ranges from 0 (best) to 42 points (worst). Between scores of 0 to 42, higher values reflect progressively greater deficit. (NCT01123161)
Timeframe: 90 days
| Intervention | units on a scale (Mean) |
|---|---|
| Group1: IV t-PA and Normothermia | 6.1 |
| Group 2 : IV t-PA and Hypothermia and Anti-shivering Treatment | 4.8 |
The Barthel index measures independence in activities of daily living from 0 (worst) to 100 (best) in 5 point increments. Higher scores between 0 and 100 reflect progressively greater levels of independence. Scores were dichotomized at 90 so that a score of 95 or 100 was considered a successful treatment. (NCT01123161)
Timeframe: 90 days
| Intervention | participants (Number) |
|---|---|
| Group1: IV t-PA and Normothermia | 25 |
| Group 2 : IV t-PA and Hypothermia and Anti-shivering Treatment | 24 |
Modified Rankin describes disability: 0 is free of any disability or symptoms, 6 is death, and higher grades between 0 and 6 reflect progressively greater disability (NCT01123161)
Timeframe: 90 days
| Intervention | participants (Number) |
|---|---|
| Group1: IV t-PA and Normothermia | 21 |
| Group 2 : IV t-PA and Hypothermia | 21 |
3 trials available for meperidine and Apoplexy
| Article | Year |
|---|---|
EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Brain Ischemia; Buspirone; Clinical Protocols; Europe; Huma | 2014 |
Determinants of effective cooling during endovascular hypothermia.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Area Under Curve; Bu | 2012 |
Feasibility and safety of inducing modest hypothermia in awake patients with acute stroke through surface cooling: A case-control study: the Copenhagen Stroke Study.
Topics: Acute Disease; Aged; Analgesics, Opioid; Blood Cell Count; Blood Chemical Analysis; Blood Pressure; | 2000 |
2 other studies available for meperidine and Apoplexy
| Article | Year |
|---|---|
Ice-cold saline for the induction of mild hypothermia in patients with acute ischemic stroke: a pilot study.
Topics: Acute Disease; Aged; Analgesics, Opioid; Blood Cell Count; Blood Chemical Analysis; Brain Ischemia; | 2009 |
The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine.
Topics: Animals; Behavior, Animal; Brain Infarction; Cerebrovascular Circulation; Hypothermia, Induced; Male | 2013 |