meperidine and Aging
meperidine has been researched along with Aging in 16 studies
Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The risk of respiratory depression increased with age." | 1.32 | Side effects of opioids during short-term administration: effect of age, gender, and race. ( Baumgarten, M; Boston, R; Carr, DB; Cepeda, MS; Farrar, JT; Strom, BL, 2003) |
| " The pharmacokinetics of meperidine varied greatly between the subjects, with a median elimination half-life of 10." | 1.28 | Pharmacokinetics and pharmacodynamics of intravenous meperidine in neonates and infants. ( Koivisto, M; Olkkola, KT; Pokela, ML; Ryhänen, P, 1992) |
| " When the drug was given intravenously (2 mg kg-1), plasma levels declined in a biexponential manner, with an elimination half-life of 62." | 1.28 | Pharmacokinetics of pethidine administered intramuscularly and intravenously to dogs over 10 years old. ( Kalthum, W; Waterman, AE, 1990) |
Research
Studies (16)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Cepeda, MS | 1 |
| Farrar, JT | 1 |
| Baumgarten, M | 1 |
| Boston, R | 1 |
| Carr, DB | 1 |
| Strom, BL | 1 |
| Nicák, A | 1 |
| Kohút, A | 1 |
| Sallingová, Z | 1 |
| Yeh, SY | 1 |
| Krebs, HA | 1 |
| Church, JJ | 1 |
| Holmberg, L | 2 |
| Odar-Cederlöf, I | 2 |
| Boréus, LO | 2 |
| Heyner, L | 1 |
| Ehrnebo, M | 2 |
| Kristoffersen, MB | 1 |
| Kjaer Hansen, EK | 1 |
| Jostell, KG | 1 |
| Stockman, O | 1 |
| Chalon, J | 1 |
| Walpert, L | 1 |
| Ramanathan, S | 1 |
| Eisner, M | 1 |
| Tang, CK | 1 |
| Katz, R | 1 |
| Turndorf, H | 1 |
| Nilsson, JL | 1 |
| Kurth, CD | 1 |
| Steven, JM | 1 |
| Nicolson, SC | 1 |
| Woodhouse, A | 1 |
| Mather, LE | 2 |
| Hall, LG | 1 |
| Oyen, LJ | 1 |
| Murray, MJ | 1 |
| Chan, K | 2 |
| Kendall, MJ | 2 |
| Wells, WD | 2 |
| Mitchard, M | 2 |
| Tucker, GT | 1 |
| Pflug, AE | 1 |
| Lindop, MJ | 1 |
| Wilkerson, C | 1 |
| Pokela, ML | 1 |
| Olkkola, KT | 1 |
| Koivisto, M | 1 |
| Ryhänen, P | 1 |
| Waterman, AE | 1 |
| Kalthum, W | 1 |
Clinical Trials (3)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461] | 137 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery[NCT02346110] | Phase 4 | 40 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| Near Infrared Spectroscopy Monitoring of Cerebral Oxygen Saturation in Neonatal Cardiac Surgery - Comparison With Common Methods of Estimating Adequate Systemic Perfusion[NCT00166101] | 25 participants (Actual) | Observational | 2002-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for meperidine and Aging
| Article | Year |
|---|---|
Analgesic agents. Pharmacology and application in critical care.
Topics: Aging; Analgesics; Analgesics, Opioid; Critical Illness; Humans; Intensive Care Units; Kidney; Liver | 2001 |
Trials
2 trials available for meperidine and Aging
| Article | Year |
|---|---|
Continuous infusion of meptazinol and pethidine in the relief of post-operative pain.
Topics: Abdomen; Adult; Aging; Azepines; Female; Humans; Infusions, Parenteral; Male; Meperidine; Meptazinol | 1983 |
The influence of age upon opioid analgesic use in the patient-controlled analgesia (PCA) environment.
Topics: Adult; Aged; Aging; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; Drug Adm | 1997 |
Other Studies
13 other studies available for meperidine and Aging
| Article | Year |
|---|---|
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
[Analgesia and age. I. Age-conditioned changes in the analgesic effect of strong analgesics in rats].
Topics: Aging; Analgesia; Animals; Meperidine; Morphine; Rats; Time Factors | 1984 |
Development of narcotic drug metabolizing enzymes in the newborn rat.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Carboxylic Ester Hydrolases; Female; Glucuronosyltran | 1980 |
Comparative disposition of pethidine and norpethidine in old and young patients.
Topics: Adolescent; Adult; Aging; Female; Half-Life; Humans; Injections, Intravenous; Male; Meperidine; Time | 1982 |
Chlormethiazole (Heminevrin), pethidine and nitrous oxide as compared to halothane for general anesthesia.
Topics: Aged; Aging; Anesthesia, General; Chlormethiazole; Halothane; Humans; Kinetics; Meperidine; Middle A | 1982 |
Meperidine-promethazine combination and learning function of mice and of their progeny.
Topics: Aging; Animals; Drug Interactions; Learning; Meperidine; Mice; Promethazine; Respiration; Sleep; Tim | 1982 |
Pethidine binding to blood cells and plasma proteins in old and young subjects.
Topics: Adult; Aged; Aging; Blood Proteins; Erythrocytes; Female; Humans; Male; Meperidine; Middle Aged; Nep | 1982 |
Cerebral oxygenation during pediatric cardiac surgery using deep hypothermic circulatory arrest.
Topics: Aging; Anesthesia; Brain; Cardiac Surgical Procedures; Child, Preschool; Fentanyl; Hemodynamics; Hum | 1995 |
Factors influencing the excretion and relative physiological availability of pethidine in man.
Topics: Administration, Oral; Aging; Biological Availability; Humans; Hydrogen-Ion Concentration; Injections | 1975 |
Meperidine kinetics in man. Intravenous injection in surgical patients and volunteers.
Topics: Adolescent; Adult; Aged; Aging; Alcohol Drinking; Anesthesia; Female; Humans; Injections, Intravenou | 1975 |
The effect of ageing on plasma pethidine concentration.
Topics: Adult; Aged; Aging; Blood Proteins; Erythrocytes; Female; Humans; In Vitro Techniques; Injections, I | 1975 |
Pharmacokinetics and pharmacodynamics of intravenous meperidine in neonates and infants.
Topics: Aging; Female; Half-Life; Humans; Infant; Infant, Newborn; Infant, Premature; Injections, Intravenou | 1992 |
Pharmacokinetics of pethidine administered intramuscularly and intravenously to dogs over 10 years old.
Topics: Absorption; Aging; Animals; Dogs; Female; Half-Life; Injections, Intramuscular; Injections, Intraven | 1990 |