Page last updated: 2024-10-30

meperidine and Aging

meperidine has been researched along with Aging in 16 studies

Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The risk of respiratory depression increased with age."1.32Side effects of opioids during short-term administration: effect of age, gender, and race. ( Baumgarten, M; Boston, R; Carr, DB; Cepeda, MS; Farrar, JT; Strom, BL, 2003)
" The pharmacokinetics of meperidine varied greatly between the subjects, with a median elimination half-life of 10."1.28Pharmacokinetics and pharmacodynamics of intravenous meperidine in neonates and infants. ( Koivisto, M; Olkkola, KT; Pokela, ML; Ryhänen, P, 1992)
" When the drug was given intravenously (2 mg kg-1), plasma levels declined in a biexponential manner, with an elimination half-life of 62."1.28Pharmacokinetics of pethidine administered intramuscularly and intravenously to dogs over 10 years old. ( Kalthum, W; Waterman, AE, 1990)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199010 (62.50)18.7374
1990's4 (25.00)18.2507
2000's2 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cepeda, MS1
Farrar, JT1
Baumgarten, M1
Boston, R1
Carr, DB1
Strom, BL1
Nicák, A1
Kohút, A1
Sallingová, Z1
Yeh, SY1
Krebs, HA1
Church, JJ1
Holmberg, L2
Odar-Cederlöf, I2
Boréus, LO2
Heyner, L1
Ehrnebo, M2
Kristoffersen, MB1
Kjaer Hansen, EK1
Jostell, KG1
Stockman, O1
Chalon, J1
Walpert, L1
Ramanathan, S1
Eisner, M1
Tang, CK1
Katz, R1
Turndorf, H1
Nilsson, JL1
Kurth, CD1
Steven, JM1
Nicolson, SC1
Woodhouse, A1
Mather, LE2
Hall, LG1
Oyen, LJ1
Murray, MJ1
Chan, K2
Kendall, MJ2
Wells, WD2
Mitchard, M2
Tucker, GT1
Pflug, AE1
Lindop, MJ1
Wilkerson, C1
Pokela, ML1
Olkkola, KT1
Koivisto, M1
Ryhänen, P1
Waterman, AE1
Kalthum, W1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461]137 participants (Actual)Observational2009-07-31Completed
Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery[NCT02346110]Phase 440 participants (Actual)Interventional2015-04-30Completed
Near Infrared Spectroscopy Monitoring of Cerebral Oxygen Saturation in Neonatal Cardiac Surgery - Comparison With Common Methods of Estimating Adequate Systemic Perfusion[NCT00166101]25 participants (Actual)Observational2002-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for meperidine and Aging

ArticleYear
Analgesic agents. Pharmacology and application in critical care.
    Critical care clinics, 2001, Volume: 17, Issue:4

    Topics: Aging; Analgesics; Analgesics, Opioid; Critical Illness; Humans; Intensive Care Units; Kidney; Liver

2001

Trials

2 trials available for meperidine and Aging

ArticleYear
Continuous infusion of meptazinol and pethidine in the relief of post-operative pain.
    Postgraduate medical journal, 1983, Volume: 59 Suppl 1

    Topics: Abdomen; Adult; Aging; Azepines; Female; Humans; Infusions, Parenteral; Male; Meperidine; Meptazinol

1983
The influence of age upon opioid analgesic use in the patient-controlled analgesia (PCA) environment.
    Anaesthesia, 1997, Volume: 52, Issue:10

    Topics: Adult; Aged; Aging; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; Drug Adm

1997

Other Studies

13 other studies available for meperidine and Aging

ArticleYear
Side effects of opioids during short-term administration: effect of age, gender, and race.
    Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta

2003
Side effects of opioids during short-term administration: effect of age, gender, and race.
    Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta

2003
Side effects of opioids during short-term administration: effect of age, gender, and race.
    Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta

2003
Side effects of opioids during short-term administration: effect of age, gender, and race.
    Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta

2003
[Analgesia and age. I. Age-conditioned changes in the analgesic effect of strong analgesics in rats].
    Casopis lekaru ceskych, 1984, Mar-09, Volume: 123, Issue:10

    Topics: Aging; Analgesia; Animals; Meperidine; Morphine; Rats; Time Factors

1984
Development of narcotic drug metabolizing enzymes in the newborn rat.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 213, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Carboxylic Ester Hydrolases; Female; Glucuronosyltran

1980
Comparative disposition of pethidine and norpethidine in old and young patients.
    European journal of clinical pharmacology, 1982, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Aging; Female; Half-Life; Humans; Injections, Intravenous; Male; Meperidine; Time

1982
Chlormethiazole (Heminevrin), pethidine and nitrous oxide as compared to halothane for general anesthesia.
    Acta anaesthesiologica Scandinavica, 1982, Volume: 26, Issue:4

    Topics: Aged; Aging; Anesthesia, General; Chlormethiazole; Halothane; Humans; Kinetics; Meperidine; Middle A

1982
Meperidine-promethazine combination and learning function of mice and of their progeny.
    Canadian Anaesthetists' Society journal, 1982, Volume: 29, Issue:6

    Topics: Aging; Animals; Drug Interactions; Learning; Meperidine; Mice; Promethazine; Respiration; Sleep; Tim

1982
Pethidine binding to blood cells and plasma proteins in old and young subjects.
    European journal of clinical pharmacology, 1982, Volume: 23, Issue:5

    Topics: Adult; Aged; Aging; Blood Proteins; Erythrocytes; Female; Humans; Male; Meperidine; Middle Aged; Nep

1982
Cerebral oxygenation during pediatric cardiac surgery using deep hypothermic circulatory arrest.
    Anesthesiology, 1995, Volume: 82, Issue:1

    Topics: Aging; Anesthesia; Brain; Cardiac Surgical Procedures; Child, Preschool; Fentanyl; Hemodynamics; Hum

1995
Factors influencing the excretion and relative physiological availability of pethidine in man.
    The Journal of pharmacy and pharmacology, 1975, Volume: 27, Issue:4

    Topics: Administration, Oral; Aging; Biological Availability; Humans; Hydrogen-Ion Concentration; Injections

1975
Meperidine kinetics in man. Intravenous injection in surgical patients and volunteers.
    Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Alcohol Drinking; Anesthesia; Female; Humans; Injections, Intravenou

1975
The effect of ageing on plasma pethidine concentration.
    British journal of clinical pharmacology, 1975, Volume: 2, Issue:4

    Topics: Adult; Aged; Aging; Blood Proteins; Erythrocytes; Female; Humans; In Vitro Techniques; Injections, I

1975
Pharmacokinetics and pharmacodynamics of intravenous meperidine in neonates and infants.
    Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:4

    Topics: Aging; Female; Half-Life; Humans; Infant; Infant, Newborn; Infant, Premature; Injections, Intravenou

1992
Pharmacokinetics of pethidine administered intramuscularly and intravenously to dogs over 10 years old.
    Research in veterinary science, 1990, Volume: 48, Issue:2

    Topics: Absorption; Aging; Animals; Dogs; Female; Half-Life; Injections, Intramuscular; Injections, Intraven

1990