Page last updated: 2024-10-30

meperidine and Addiction, Opioid

meperidine has been researched along with Addiction, Opioid in 32 studies

Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the proportion of drug abuse related to opioid analgesics and the trends in medical use and abuse of 5 opioid analgesics used to treat severe pain: fentanyl, hydromorphone, meperidine, morphine, and oxycodone."3.70Trends in medical use and abuse of opioid analgesics. ( Dahl, JL; Gilson, AM; Joranson, DE; Ryan, KM, 2000)
"Meperidine was measured by GC-FID during 72 h after intramuscular administration of meperidine to an addict."1.29Investigation of meperidine and its metabolites in urine of an addict by gas chromatography-flame ionization detection and gas chromatography-mass spectrometry. ( Hu, X; Liu, F; Luo, Y, 1994)
"Rats treated with morphine showed withdrawal signs such as hyperirritability, salivation, diarrhea, and weight loss."1.28Physical dependence potential of an enkephalin analog, EK-399, in rats. ( Nishida, N, 1990)
"Amphetamine alone was rarely the cause of death but the drug was seen in an increasing number of deaths in recent years."1.28[Narcotic abuse in Jylland. A study based on narcotics and deaths of addicts examined at the Institute of Forensic Medicine, University of Aarhus during the period 1981-1988. 2. Deaths among addicts]. ( Kaa, E, 1990)
" Chronic administration of codeine (0."1.27Urinary sex-dependent low molecular weight proteins as a sign of narcotic dependence in male rats. ( Akiba, I; Endou, H; Sakai, F; Suzuki, T; Yanaura, S, 1983)
"Meperidine was the preferred opiate."1.26Drug addiction among Quebec physicians. ( Lambert, J; Wallot, H, 1982)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199016 (50.00)18.7374
1990's7 (21.88)18.2507
2000's6 (18.75)29.6817
2010's3 (9.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rolland, B1
Bera-Louville, A1
Deheul, S1
Roche, J1
Blond, S1
Cottencin, O1
Rozas-Muñoz, E1
García-Muret, MP1
Puig, L1
Lewis, J1
Shimmon, R1
Fu, S1
WEEKS, JR1
ROSENTHAL, T1
PATRICK, SW1
KRUG, DC1
Little, M1
Hansen, GR1
Shipton, E1
Nakaki, T1
Muraki, T1
Tokunaga, Y1
Kato, R1
Suzuki, T3
Yoshii, T1
Yanaura, S4
Akiba, I2
Endou, H2
Sakai, F2
Langston, JW1
Ballard, P1
Tetrud, JW1
Irwin, I1
Smith, M1
Wallot, H1
Lambert, J1
Cuvillier, P1
Gomez, J1
Dupont, T1
Socolovsky, C1
Peltier, JM1
Goucke, CR1
Graziotti, PJ1
Liu, F1
Hu, X1
Luo, Y1
Gruber, RP1
Jackson, BS1
Fletcher, C1
Baker, D1
Miller, TA1
Joranson, DE1
Ryan, KM1
Gilson, AM1
Dahl, JL1
Berbatis, CG1
Sunderland, VB1
Bulsara, M1
Lintzeris, N1
Davis, GC1
Williams, AC1
Markey, SP1
Ebert, MH1
Caine, ED1
Reichert, CM1
Kopin, IJ1
Tagashira, E1
Izumi, T1
Tuttle, S1
Nishida, N1
Kaa, E1
Koren, G1
Maurice, L1
Brinton, LF1
Fincannon, J1
Hagelsten, JO1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Opioid-Induced Hyperalgesia in Prescription Opioid Abusers: Effects of Pregabalin[NCT01821430]Phase 24 participants (Actual)Interventional2013-03-31Terminated (stopped due to poor recruitment)
Effects of Chronic Musculoskeletal Pain and Opioidergic Versus Placebo Interventions on Neuroendocrine Function in Men[NCT00737737]Phase 48 participants (Actual)Interventional2008-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Is Chronic Opioid Treatment Associated With Changes in Adrenocorticotropic Hormone (ACTH), Cortisol, Luteinizing Hormone (LH) and Testosterone Secretion?

(NCT00737737)
Timeframe: 4 weeks

Interventionng/ml (Number)
OpioidNA
PlaceboNA

Is Placebo Analgesia Associated With a Similar Hormonal Response as Elicited by an Opioid Analgesic?

(NCT00737737)
Timeframe: 4 weeks

Interventionng/ml (Number)
OpioidNA
PlaceboNA

Reviews

3 reviews available for meperidine and Addiction, Opioid

ArticleYear
The drug-seeking patient in the emergency room.
    Emergency medicine clinics of North America, 2005, Volume: 23, Issue:2

    Topics: Analgesics, Opioid; Chronic Disease; Emergency Medicine; Emergency Service, Hospital; Humans; Meperi

2005
Should New Zealand continue signing up to the Pethidine Protocol?
    The New Zealand medical journal, 2006, Mar-10, Volume: 119, Issue:1230

    Topics: Analgesics, Opioid; Cost-Benefit Analysis; Drug and Narcotic Control; Drug Evaluation; Drug Interact

2006
Pediatric uses of opioids.
    Pediatric clinics of North America, 1989, Volume: 36, Issue:5

    Topics: Child; Child, Preschool; Codeine; Drug Interactions; Fentanyl; Humans; Infant; Infant, Newborn; Mepe

1989

Other Studies

29 other studies available for meperidine and Addiction, Opioid

ArticleYear
[Iatrogenic dependence to meperidine in the elderly].
    Presse medicale (Paris, France : 1983), 2014, Volume: 43, Issue:6 Pt 1

    Topics: Administration, Oral; Aged; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Buprenorphine; Chron

2014
Chronic ulceration and fibrosis of the forearm.
    JAMA dermatology, 2015, Volume: 151, Issue:3

    Topics: Adult; Chronic Disease; Fibrosis; Forearm; Humans; Male; Meperidine; Narcotics; Opioid-Related Disor

2015
Pethidinic acid: corroboration of a doctor's denial of pethidine re-use.
    Journal of analytical toxicology, 2013, Volume: 37, Issue:3

    Topics: Analgesics, Opioid; Biomarkers; Biotransformation; Calibration; Humans; Limit of Detection; Meperidi

2013
EXPERIMENTAL NARCOTIC ADDICTION.
    Scientific American, 1964, Volume: 210

    Topics: Animals; Codeine; Conditioning, Psychological; Equipment and Supplies; Haplorhini; Injections, Intra

1964
CONGENITAL NEONATAL NARCOTICS ADDICTION: A NATURAL HISTORY.
    American journal of public health and the nation's health, 1964, Volume: 54

    Topics: Chlorpromazine; Female; Humans; Maternal-Fetal Exchange; Meperidine; Methadone; Morphine Dependence;

1964
Big black spider bite from the desert region of Western Australia.
    Emergency medicine Australasia : EMA, 2005, Volume: 17, Issue:2

    Topics: Adult; Analgesics, Opioid; Angiolipoma; Diagnosis, Differential; Humans; Male; Meperidine; Opioid-Re

2005
Plasma cyclic AMP in the pethidine-dependent rat.
    Japanese journal of pharmacology, 1981, Volume: 31, Issue:6

    Topics: Animals; Blood Glucose; Cyclic AMP; Humans; Male; Meperidine; Opioid-Related Disorders; Rats; Rats,

1981
[Assessment of morphine-type physical dependence liability in mice using the drug-admixed food method].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1984, Volume: 84, Issue:1

    Topics: Administration, Oral; Animals; Codeine; Disease Models, Animal; Humans; Male; Meperidine; Mice; Mice

1984
Narcotic physical dependence and urinary sex-dependent low molecular weight proteins in male rats.
    Journal of pharmacobio-dynamics, 1983, Volume: 6, Issue:3

    Topics: Animals; Female; Humans; Male; Meperidine; Molecular Weight; Morphine; Naloxone; Opioid-Related Diso

1983
Urinary sex-dependent low molecular weight proteins as a sign of narcotic dependence in male rats.
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1983, Volume: 3, Issue:2

    Topics: Albuminuria; Animals; Codeine; Humans; Male; Meperidine; Molecular Weight; Opioid-Related Disorders;

1983
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.
    Science (New York, N.Y.), 1983, Feb-25, Volume: 219, Issue:4587

    Topics: Adult; Female; Humans; Male; Meperidine; Opioid-Related Disorders; Parkinson Disease, Secondary; Sub

1983
Sharing: another definition of caring.
    Nursing, 1982, Volume: 12, Issue:7

    Topics: Adult; Female; Humans; Meperidine; Nursing Staff, Hospital; Opioid-Related Disorders

1982
Drug addiction among Quebec physicians.
    Canadian Medical Association journal, 1982, Apr-15, Volume: 126, Issue:8

    Topics: Age Factors; Depression; Ethnicity; Humans; Life Style; Marriage; Meperidine; Opioid-Related Disorde

1982
[A case of acute rhabdomyolysis in poisoning by morphine-like drugs].
    LARC medical, 1982, Volume: 2, Issue:11

    Topics: Acute Disease; Adult; Humans; Male; Meperidine; Muscular Diseases; Opioid-Related Disorders; Opium

1982
Painful lessons: opioids, iatrogenic dependence and professional standards.
    The Medical journal of Australia, 1995, Nov-06, Volume: 163, Issue:9

    Topics: Drug Utilization; Humans; Iatrogenic Disease; Meperidine; Opioid-Related Disorders; Pain

1995
Investigation of meperidine and its metabolites in urine of an addict by gas chromatography-flame ionization detection and gas chromatography-mass spectrometry.
    Journal of chromatography. B, Biomedical applications, 1994, Aug-19, Volume: 658, Issue:2

    Topics: Biotransformation; Gas Chromatography-Mass Spectrometry; Humans; Meperidine; Opioid-Related Disorder

1994
A member's experience with the state medical board.
    Plastic and reconstructive surgery, 1996, Volume: 97, Issue:6

    Topics: Analgesics, Opioid; California; Female; Humans; Licensure, Medical; Medical Records; Meperidine; Opi

1996
An administrative blunder. A nurse accused of mishandling controlled substances continues practicing.
    The Journal of nursing administration, 1997, Volume: 27, Issue:12

    Topics: Documentation; Drug and Narcotic Control; Employment; Female; Humans; Male; Meperidine; Nursing Staf

1997
Trends in medical use and abuse of opioid analgesics.
    JAMA, 2000, Apr-05, Volume: 283, Issue:13

    Topics: Analgesics, Opioid; Drug Utilization; Fentanyl; Humans; Hydromorphone; Meperidine; Morphine; Opioid-

2000
Trends in licit opioid use in Australia, 1984-1998: comparative analysis of international and jurisdictional data.
    The Medical journal of Australia, 2000, Nov-20, Volume: 173, Issue:10

    Topics: Australia; Developed Countries; Drug Utilization; Humans; Meperidine; Methadone; Morphine; Narcotics

2000
Discipline following conviction in the district court.
    The New Zealand medical journal, 2001, Jul-13, Volume: 114, Issue:1135

    Topics: Alcohol Drinking; Humans; Meperidine; Morphine Dependence; New Zealand; Opioid-Related Disorders; Ph

2001
Chronic Parkinsonism secondary to intravenous injection of meperidine analogues.
    Psychiatry research, 1979, Volume: 1, Issue:3

    Topics: Adult; Bromocriptine; Carbidopa; Chronic Disease; Humans; Levodopa; Locus Coeruleus; Male; Meperidin

1979
Screening method for drug dependence liability using drug-admixed food (DAF) method.
    Pharmacology & therapeutics. Part B: General & systematic pharmacology, 1979, Volume: 5, Issue:1-3

    Topics: Animals; Barbiturates; Codeine; Drug Evaluation, Preclinical; Food; Humans; Male; Meperidine; Method

1979
Letter to a nurse-addict's friend.
    The American journal of nursing, 1991, Volume: 91, Issue:11

    Topics: Female; Humans; Interprofessional Relations; Meperidine; Nurses; Oncology Nursing; Opioid-Related Di

1991
Physical dependence potential of an enkephalin analog, EK-399, in rats.
    Japanese journal of pharmacology, 1990, Volume: 53, Issue:4

    Topics: Animals; Body Weight; Enkephalins; Infusions, Intravenous; Male; Meperidine; Morphine; Naloxone; Opi

1990
[Narcotic abuse in Jylland. A study based on narcotics and deaths of addicts examined at the Institute of Forensic Medicine, University of Aarhus during the period 1981-1988. 2. Deaths among addicts].
    Ugeskrift for laeger, 1990, Apr-09, Volume: 152, Issue:15

    Topics: Adolescent; Adult; Alcoholic Intoxication; Amphetamine; Denmark; Dextropropoxyphene; Female; Heroin

1990
Who is to blame?
    North Carolina medical journal, 1988, Volume: 49, Issue:11

    Topics: Headache; Humans; Male; Meperidine; Opioid-Related Disorders; Physician's Role; Role

1988
Meperidine addiction associated with amphoteracin treatment in leukemia: case study and staff reaction.
    Archives of psychiatric nursing, 1988, Volume: 2, Issue:5

    Topics: Amphotericin B; Female; Humans; Iatrogenic Disease; Leukemia, Myeloid, Acute; Meperidine; Opioid-Rel

1988
[Designer narcotics].
    Ugeskrift for laeger, 1987, Apr-20, Volume: 149, Issue:17

    Topics: Amphetamines; Cocaine; Fentanyl; Humans; Meperidine; Mescaline; Narcotics; Opioid-Related Disorders

1987