menthol has been researched along with Pruritus in 24 studies
Menthol: A monoterpene cyclohexanol produced from mint oils.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A cream that contains menthol and diphenhydramine is widely prepared in hospital pharmacies and prescribed to patients for the treatment of pruritus associated with chronic kidney disease." | 7.81 | Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus. ( Machida, Y; Onuki, Y; Sakurai, S; Seike, C; Takayama, K; Yokawa, T, 2015) |
| "The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL)." | 7.69 | Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. ( Hui, XY; Maibach, H; Szolar, C; Yosipovitch, G, 1996) |
| "Pruritus is a common side effect." | 5.35 | Hydroxyethyl starch-induced pruritus relieved by a combination of menthol and camphor. ( English, JC; Haught, JM; Jukic, DM, 2008) |
| "A phenol one percent and menthol one percent combination has significant therapeutic effects for mustard gas-induced pruritus in chemical warfare-injured veterans, in comparison with the placebo." | 5.12 | Phenol and menthol in the treatment of chronic skin lesions following mustard gas exposure. ( Bigdeli, M; Dashti-Khavidaki, S; Davoodi, SM; Khalili, H; Panahi, Y, 2007) |
| " The aim of our study was to evaluate the efficacy of a detergent containing dihydroavenanthramide D 5% combined with a moisturizer containing 1% of menthol for the treatment of chronic pruritus associated with xerosis in elderly KS patients." | 3.96 | Efficacy of a detergent combined with a moisturizer for the treatment of pruritus associated with xerosis in an elderly population affected by Kaposi's sarcoma. ( Brambilla, L; Consonni, D; Genovese, G; Tourlaki, A, 2020) |
| "A cream that contains menthol and diphenhydramine is widely prepared in hospital pharmacies and prescribed to patients for the treatment of pruritus associated with chronic kidney disease." | 3.81 | Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus. ( Machida, Y; Onuki, Y; Sakurai, S; Seike, C; Takayama, K; Yokawa, T, 2015) |
| "The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL)." | 3.69 | Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. ( Hui, XY; Maibach, H; Szolar, C; Yosipovitch, G, 1996) |
| "Histamine 1% was applied to the volar forearms using skin prick-test lancets." | 2.84 | Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Hilborg, SD; Jerwiarz, A; Melholt, C; Randers, A; Simoni, A, 2017) |
| "Chronic pruritus is a common problem in patients with inflammatory skin diseases as well as in subjects with dry or sensitive skin." | 2.53 | Itch Management: Topical Agents. ( Metz, M; Staubach, P, 2016) |
| "Pruritus is the predominant symptom of skin disease." | 2.46 | Therapy of pruritus. ( Patel, T; Yosipovitch, G, 2010) |
| "Pruritus is a common side effect." | 1.35 | Hydroxyethyl starch-induced pruritus relieved by a combination of menthol and camphor. ( English, JC; Haught, JM; Jukic, DM, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Palkar, R | 1 |
| Ongun, S | 1 |
| Catich, E | 1 |
| Li, N | 1 |
| Borad, N | 1 |
| Sarkisian, A | 1 |
| McKemy, DD | 1 |
| Tourlaki, A | 1 |
| Genovese, G | 1 |
| Consonni, D | 1 |
| Brambilla, L | 1 |
| Nanes, BA | 1 |
| Chong, BF | 1 |
| Cao, T | 1 |
| Tey, HL | 1 |
| Yosipovitch, G | 4 |
| Misery, L | 1 |
| Santerre, A | 1 |
| Batardière, A | 1 |
| Hornez, N | 1 |
| Nedelec, AS | 1 |
| Le Caër, F | 1 |
| Bourgeois, P | 1 |
| Huet, F | 1 |
| Neufang, G | 1 |
| Greco, V | 1 |
| Fattore, D | 1 |
| Annunziata, MC | 1 |
| Fabbrocini, G | 1 |
| Hondebrink, L | 1 |
| Opstelten, W | 1 |
| Onuki, Y | 1 |
| Machida, Y | 1 |
| Yokawa, T | 1 |
| Seike, C | 1 |
| Sakurai, S | 1 |
| Takayama, K | 1 |
| Pradhananga, S | 1 |
| Shim, WS | 1 |
| Andersen, HH | 1 |
| Melholt, C | 1 |
| Hilborg, SD | 1 |
| Jerwiarz, A | 1 |
| Randers, A | 1 |
| Simoni, A | 1 |
| Elberling, J | 1 |
| Arendt-Nielsen, L | 1 |
| Metz, M | 1 |
| Staubach, P | 1 |
| Alenmyr, L | 1 |
| Högestätt, ED | 1 |
| Zygmunt, PM | 1 |
| Greiff, L | 1 |
| Frölich, M | 1 |
| Enk, A | 1 |
| Diepgen, TL | 1 |
| Weisshaar, E | 1 |
| Naono-Nakayama, R | 1 |
| Sunakawa, N | 1 |
| Ikeda, T | 1 |
| Nishimori, T | 1 |
| Patel, T | 2 |
| HEILGEMEIR, G | 1 |
| Lateef, F | 1 |
| Panahi, Y | 1 |
| Davoodi, SM | 1 |
| Khalili, H | 1 |
| Dashti-Khavidaki, S | 1 |
| Bigdeli, M | 1 |
| Haught, JM | 1 |
| Jukic, DM | 1 |
| English, JC | 1 |
| Bromm, B | 1 |
| Scharein, E | 1 |
| Darsow, U | 1 |
| Ring, J | 1 |
| Szolar, C | 1 |
| Hui, XY | 1 |
| Maibach, H | 1 |
| Vilaplana, J | 1 |
| Romaguera, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
5 reviews available for menthol and Pruritus
| Article | Year |
|---|---|
SnapshotDx Quiz: June 2018.
Topics: Administration, Cutaneous; Antipruritics; Chronic Disease; Cold Temperature; Humans; Menthol; Prurit | 2018 |
Chronic Pruritus in the Geriatric Population.
Topics: Aged; Aged, 80 and over; Aging; Antidepressive Agents; Antipruritics; Calcineurin Inhibitors; Capsai | 2018 |
Itch Management: Topical Agents.
Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Local; Antipruritics; Camphor; Cannabino | 2016 |
Therapy of pruritus.
Topics: Adrenal Cortex Hormones; Antidepressive Agents; Antipsychotic Agents; Capsaicin; Emollients; Histami | 2010 |
The management of chronic pruritus in the elderly.
Topics: Administration, Oral; Administration, Topical; Aged; Antipruritics; Cannabinoids; Capsaicin; Central | 2010 |
2 trials available for menthol and Pruritus
| Article | Year |
|---|---|
Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans.
Topics: Acrolein; Antipruritics; Cold Temperature; Doxepin; Female; Healthy Volunteers; Histamine; Histamine | 2017 |
Phenol and menthol in the treatment of chronic skin lesions following mustard gas exposure.
Topics: Administration, Topical; Antipruritics; Chemical Warfare Agents; Double-Blind Method; Drug Combinati | 2007 |
17 other studies available for menthol and Pruritus
| Article | Year |
|---|---|
Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.
Topics: Animals; Antipruritics; Behavior, Animal; Capsaicin; Chloroquine; Chronic Disease; Cryotherapy; Dise | 2018 |
Efficacy of a detergent combined with a moisturizer for the treatment of pruritus associated with xerosis in an elderly population affected by Kaposi's sarcoma.
Topics: Aged; Aged, 80 and over; Detergents; Emollients; Female; Humans; Male; Menthol; ortho-Aminobenzoates | 2020 |
Real-life study of anti-itching effects of a cream containing menthoxypropanediol, a TRPM8 agonist, in atopic dermatitis patients.
Topics: Adult; Antipruritics; Dermatitis, Atopic; Female; Humans; Male; Menthol; Middle Aged; Pruritus; Skin | 2019 |
Combination of permethrin 5% cream with liquid cleanser containing Chlorhexidine, agents from Szechuan peppers, menthol and camphor in scabies treatment.
Topics: Adolescent; Adult; Anti-Infective Agents, Local; Antipruritics; Camphor; Capsicum; Chlorhexidine; Dr | 2019 |
A woman with an itchy hyperpigmentation on her back.
Topics: Aged; Back; Female; Histamine Antagonists; Humans; Hyperpigmentation; Menthol; Pain; Pruritus; Skin; | 2019 |
Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus.
Topics: Diphenhydramine; Drug Stability; Histamine H1 Antagonists; Humans; Hydrophobic and Hydrophilic Inter | 2015 |
Caffeic acid exhibits anti-pruritic effects by inhibition of multiple itch transmission pathways in mice.
Topics: Animals; Behavior, Animal; Caffeic Acids; Chloroquine; HEK293 Cells; Histamine; Humans; Menthol; Mic | 2015 |
TRPV1-mediated itch in seasonal allergic rhinitis.
Topics: Acrolein; Adult; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Antipruritics; Arachidonic Acid | 2009 |
Successful treatment of therapy-resistant pruritus in lichen amyloidosis with menthol.
Topics: Administration, Topical; Aged; Amyloidosis; Antipruritics; Drug Resistance; Female; Humans; Lichenoi | 2009 |
Differential effects of substance P or hemokinin-1 on transient receptor potential channels, TRPV1, TRPA1 and TRPM8, in the rat.
Topics: Acrolein; Animals; Ankyrins; Behavior, Animal; Calcium Channels; Diterpenes; Injections, Spinal; Mal | 2010 |
[Synergy of drug and vehicle in the treatment of itching dermatoses].
Topics: Camphor; Gels; Humans; Hyoscyamus; Menthol; Pruritus; Skin Diseases | 1955 |
Dandruff, seborrheic dermatitis, and psoriasis drug products containing coal tar and menthol for over-the-counter human use; amendment to the monograph. Final rule.
Topics: Antipruritics; Coal Tar; Consumer Product Safety; Dermatitis, Seborrheic; Drug Therapy, Combination; | 2007 |
Of pruritus and terrorism...
Topics: Antipruritics; Chemical Warfare Agents; Decontamination; Humans; Menthol; Mustard Gas; Phenol; Pruri | 2007 |
Hydroxyethyl starch-induced pruritus relieved by a combination of menthol and camphor.
Topics: Administration, Topical; Adult; Aortic Aneurysm; Aortic Dissection; Camphor; Drug Administration Sch | 2008 |
Effects of menthol and cold on histamine-induced itch and skin reactions in man.
Topics: Adult; Cold Temperature; Histamine; Humans; Male; Menthol; Pruritus; Skin; Temperature; Time Factors | 1995 |
Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin.
Topics: Administration, Topical; Adult; Biophysical Phenomena; Biophysics; Female; Histamine; Hot Temperatur | 1996 |
Allergic contact dermatitis due to eucalyptol in an anti-inflammatory cream.
Topics: Adult; Allergens; Anti-Inflammatory Agents; Cyclohexanols; Dermatitis, Allergic Contact; Dermatitis, | 2000 |