Page last updated: 2024-10-21

menthol and Pruritus

menthol has been researched along with Pruritus in 24 studies

Menthol: A monoterpene cyclohexanol produced from mint oils.

Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

Research Excerpts

ExcerptRelevanceReference
"A cream that contains menthol and diphenhydramine is widely prepared in hospital pharmacies and prescribed to patients for the treatment of pruritus associated with chronic kidney disease."7.81Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus. ( Machida, Y; Onuki, Y; Sakurai, S; Seike, C; Takayama, K; Yokawa, T, 2015)
"The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL)."7.69Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. ( Hui, XY; Maibach, H; Szolar, C; Yosipovitch, G, 1996)
"Pruritus is a common side effect."5.35Hydroxyethyl starch-induced pruritus relieved by a combination of menthol and camphor. ( English, JC; Haught, JM; Jukic, DM, 2008)
"A phenol one percent and menthol one percent combination has significant therapeutic effects for mustard gas-induced pruritus in chemical warfare-injured veterans, in comparison with the placebo."5.12Phenol and menthol in the treatment of chronic skin lesions following mustard gas exposure. ( Bigdeli, M; Dashti-Khavidaki, S; Davoodi, SM; Khalili, H; Panahi, Y, 2007)
" The aim of our study was to evaluate the efficacy of a detergent containing dihydroavenanthramide D 5% combined with a moisturizer containing 1% of menthol for the treatment of chronic pruritus associated with xerosis in elderly KS patients."3.96Efficacy of a detergent combined with a moisturizer for the treatment of pruritus associated with xerosis in an elderly population affected by Kaposi's sarcoma. ( Brambilla, L; Consonni, D; Genovese, G; Tourlaki, A, 2020)
"A cream that contains menthol and diphenhydramine is widely prepared in hospital pharmacies and prescribed to patients for the treatment of pruritus associated with chronic kidney disease."3.81Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus. ( Machida, Y; Onuki, Y; Sakurai, S; Seike, C; Takayama, K; Yokawa, T, 2015)
"The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL)."3.69Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. ( Hui, XY; Maibach, H; Szolar, C; Yosipovitch, G, 1996)
"Histamine 1% was applied to the volar forearms using skin prick-test lancets."2.84Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Hilborg, SD; Jerwiarz, A; Melholt, C; Randers, A; Simoni, A, 2017)
"Chronic pruritus is a common problem in patients with inflammatory skin diseases as well as in subjects with dry or sensitive skin."2.53Itch Management: Topical Agents. ( Metz, M; Staubach, P, 2016)
"Pruritus is the predominant symptom of skin disease."2.46Therapy of pruritus. ( Patel, T; Yosipovitch, G, 2010)
"Pruritus is a common side effect."1.35Hydroxyethyl starch-induced pruritus relieved by a combination of menthol and camphor. ( English, JC; Haught, JM; Jukic, DM, 2008)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.17)18.7374
1990's2 (8.33)18.2507
2000's7 (29.17)29.6817
2010's13 (54.17)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Palkar, R1
Ongun, S1
Catich, E1
Li, N1
Borad, N1
Sarkisian, A1
McKemy, DD1
Tourlaki, A1
Genovese, G1
Consonni, D1
Brambilla, L1
Nanes, BA1
Chong, BF1
Cao, T1
Tey, HL1
Yosipovitch, G4
Misery, L1
Santerre, A1
Batardière, A1
Hornez, N1
Nedelec, AS1
Le Caër, F1
Bourgeois, P1
Huet, F1
Neufang, G1
Greco, V1
Fattore, D1
Annunziata, MC1
Fabbrocini, G1
Hondebrink, L1
Opstelten, W1
Onuki, Y1
Machida, Y1
Yokawa, T1
Seike, C1
Sakurai, S1
Takayama, K1
Pradhananga, S1
Shim, WS1
Andersen, HH1
Melholt, C1
Hilborg, SD1
Jerwiarz, A1
Randers, A1
Simoni, A1
Elberling, J1
Arendt-Nielsen, L1
Metz, M1
Staubach, P1
Alenmyr, L1
Högestätt, ED1
Zygmunt, PM1
Greiff, L1
Frölich, M1
Enk, A1
Diepgen, TL1
Weisshaar, E1
Naono-Nakayama, R1
Sunakawa, N1
Ikeda, T1
Nishimori, T1
Patel, T2
HEILGEMEIR, G1
Lateef, F1
Panahi, Y1
Davoodi, SM1
Khalili, H1
Dashti-Khavidaki, S1
Bigdeli, M1
Haught, JM1
Jukic, DM1
English, JC1
Bromm, B1
Scharein, E1
Darsow, U1
Ring, J1
Szolar, C1
Hui, XY1
Maibach, H1
Vilaplana, J1
Romaguera, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]Phase 213 participants (Actual)Interventional2017-05-23Terminated (stopped due to Efficacy was not seen after interim analysis)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

InterventionIntensity score (Mean)
Topical KeAmLi Combo62.7
Topical Ketamine63.1
Topical Amitriptyline69.2
Topical Lidocaine65.8
Topical Vehicle61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,
InterventionmN (Mean)
Mechanical Detection ThresholdMechanical Pain Threshold
Topical Amitriptyline3.573423965152.4768146
Topical KeAmLi Combo3.519376956152.3293608
Topical Ketamine3.464204768135.9
Topical Lidocaine3.546037659126.9
Topical Vehicle3.525692637148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

,,,,
InterventionDegrees celsius (Mean)
Warm Detection ThresholdHeat Pain Threshold
Topical Amitriptyline33.940.0
Topical KeAmLi Combo33.639.8
Topical Ketamine34.040.0
Topical Lidocaine33.739.4
Topical Vehicle33.839.7

Reviews

5 reviews available for menthol and Pruritus

ArticleYear
SnapshotDx Quiz: June 2018.
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:6

    Topics: Administration, Cutaneous; Antipruritics; Chronic Disease; Cold Temperature; Humans; Menthol; Prurit

2018
Chronic Pruritus in the Geriatric Population.
    Dermatologic clinics, 2018, Volume: 36, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Antidepressive Agents; Antipruritics; Calcineurin Inhibitors; Capsai

2018
Itch Management: Topical Agents.
    Current problems in dermatology, 2016, Volume: 50

    Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Local; Antipruritics; Camphor; Cannabino

2016
Therapy of pruritus.
    Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:10

    Topics: Adrenal Cortex Hormones; Antidepressive Agents; Antipsychotic Agents; Capsaicin; Emollients; Histami

2010
The management of chronic pruritus in the elderly.
    Skin therapy letter, 2010, Volume: 15, Issue:8

    Topics: Administration, Oral; Administration, Topical; Aged; Antipruritics; Cannabinoids; Capsaicin; Central

2010

Trials

2 trials available for menthol and Pruritus

ArticleYear
Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans.
    Acta dermato-venereologica, 2017, 01-04, Volume: 97, Issue:1

    Topics: Acrolein; Antipruritics; Cold Temperature; Doxepin; Female; Healthy Volunteers; Histamine; Histamine

2017
Phenol and menthol in the treatment of chronic skin lesions following mustard gas exposure.
    Singapore medical journal, 2007, Volume: 48, Issue:5

    Topics: Administration, Topical; Antipruritics; Chemical Warfare Agents; Double-Blind Method; Drug Combinati

2007

Other Studies

17 other studies available for menthol and Pruritus

ArticleYear
Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:6

    Topics: Animals; Antipruritics; Behavior, Animal; Capsaicin; Chloroquine; Chronic Disease; Cryotherapy; Dise

2018
Efficacy of a detergent combined with a moisturizer for the treatment of pruritus associated with xerosis in an elderly population affected by Kaposi's sarcoma.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2020, Volume: 155, Issue:4

    Topics: Aged; Aged, 80 and over; Detergents; Emollients; Female; Humans; Male; Menthol; ortho-Aminobenzoates

2020
Real-life study of anti-itching effects of a cream containing menthoxypropanediol, a TRPM8 agonist, in atopic dermatitis patients.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2019, Volume: 33, Issue:2

    Topics: Adult; Antipruritics; Dermatitis, Atopic; Female; Humans; Male; Menthol; Middle Aged; Pruritus; Skin

2019
Combination of permethrin 5% cream with liquid cleanser containing Chlorhexidine, agents from Szechuan peppers, menthol and camphor in scabies treatment.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2019, Volume: 154, Issue:5

    Topics: Adolescent; Adult; Anti-Infective Agents, Local; Antipruritics; Camphor; Capsicum; Chlorhexidine; Dr

2019
A woman with an itchy hyperpigmentation on her back.
    BMJ (Clinical research ed.), 2019, Apr-11, Volume: 365

    Topics: Aged; Back; Female; Histamine Antagonists; Humans; Hyperpigmentation; Menthol; Pain; Pruritus; Skin;

2019
Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus.
    Chemical & pharmaceutical bulletin, 2015, Volume: 63, Issue:6

    Topics: Diphenhydramine; Drug Stability; Histamine H1 Antagonists; Humans; Hydrophobic and Hydrophilic Inter

2015
Caffeic acid exhibits anti-pruritic effects by inhibition of multiple itch transmission pathways in mice.
    European journal of pharmacology, 2015, Sep-05, Volume: 762

    Topics: Animals; Behavior, Animal; Caffeic Acids; Chloroquine; HEK293 Cells; Histamine; Humans; Menthol; Mic

2015
TRPV1-mediated itch in seasonal allergic rhinitis.
    Allergy, 2009, Volume: 64, Issue:5

    Topics: Acrolein; Adult; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Antipruritics; Arachidonic Acid

2009
Successful treatment of therapy-resistant pruritus in lichen amyloidosis with menthol.
    Acta dermato-venereologica, 2009, Volume: 89, Issue:5

    Topics: Administration, Topical; Aged; Amyloidosis; Antipruritics; Drug Resistance; Female; Humans; Lichenoi

2009
Differential effects of substance P or hemokinin-1 on transient receptor potential channels, TRPV1, TRPA1 and TRPM8, in the rat.
    Neuropeptides, 2010, Volume: 44, Issue:1

    Topics: Acrolein; Animals; Ankyrins; Behavior, Animal; Calcium Channels; Diterpenes; Injections, Spinal; Mal

2010
[Synergy of drug and vehicle in the treatment of itching dermatoses].
    Die Medizinische, 1955, Oct-15, Issue:42

    Topics: Camphor; Gels; Humans; Hyoscyamus; Menthol; Pruritus; Skin Diseases

1955
Dandruff, seborrheic dermatitis, and psoriasis drug products containing coal tar and menthol for over-the-counter human use; amendment to the monograph. Final rule.
    Federal register, 2007, Mar-06, Volume: 72, Issue:43

    Topics: Antipruritics; Coal Tar; Consumer Product Safety; Dermatitis, Seborrheic; Drug Therapy, Combination;

2007
Of pruritus and terrorism...
    Singapore medical journal, 2007, Volume: 48, Issue:5

    Topics: Antipruritics; Chemical Warfare Agents; Decontamination; Humans; Menthol; Mustard Gas; Phenol; Pruri

2007
Hydroxyethyl starch-induced pruritus relieved by a combination of menthol and camphor.
    Journal of the American Academy of Dermatology, 2008, Volume: 59, Issue:1

    Topics: Administration, Topical; Adult; Aortic Aneurysm; Aortic Dissection; Camphor; Drug Administration Sch

2008
Effects of menthol and cold on histamine-induced itch and skin reactions in man.
    Neuroscience letters, 1995, Mar-10, Volume: 187, Issue:3

    Topics: Adult; Cold Temperature; Histamine; Humans; Male; Menthol; Pruritus; Skin; Temperature; Time Factors

1995
Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin.
    Archives of dermatological research, 1996, Volume: 288, Issue:5-6

    Topics: Administration, Topical; Adult; Biophysical Phenomena; Biophysics; Female; Histamine; Hot Temperatur

1996
Allergic contact dermatitis due to eucalyptol in an anti-inflammatory cream.
    Contact dermatitis, 2000, Volume: 43, Issue:2

    Topics: Adult; Allergens; Anti-Inflammatory Agents; Cyclohexanols; Dermatitis, Allergic Contact; Dermatitis,

2000