menthol has been researched along with Nerve Pain in 19 studies
Menthol: A monoterpene cyclohexanol produced from mint oils.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topical high-concentration L-menthol consistently induces cold hypersensitivity in animals and humans, thus constituting a predictable surrogate model of cold allodynia and hyperalgesia." | 8.90 | A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia. ( Andersen, HH; Arendt-Nielsen, L; Eskelund, PW; Gazerani, P; Møller, HG; Olsen, RV, 2014) |
| "Menthol has previously been suggested as a model for hypersensitivity, but it has not yet been investigated if different levels of neuropathic pain may influence the effects of menthol or if topical application of menthol may act as a model for hypersensitivity in patients with phantom limb pain." | 5.39 | The effects of menthol on cold allodynia and wind-up-like pain in upper limb amputees with different levels of phantom limb pain. ( Arendt-Nielsen, L; Jensen, TS; Nikolajsen, L; Svensson, P; Vase, L, 2013) |
| "Both treatments resulted in cold and mechanical allodynia." | 5.38 | Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats. ( Aoki, M; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K, 2012) |
| "Topical high-concentration L-menthol consistently induces cold hypersensitivity in animals and humans, thus constituting a predictable surrogate model of cold allodynia and hyperalgesia." | 4.90 | A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia. ( Andersen, HH; Arendt-Nielsen, L; Eskelund, PW; Gazerani, P; Møller, HG; Olsen, RV, 2014) |
| " Potent analgesic activity was observed in models of neuropathic pain, and the compound blocked capsaicin induced allodynia, showing dermal accumulation with little transdermal absorption." | 3.96 | Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic. ( Ann, J; Blumberg, PM; Choi, K; Esch, TE; Ha, HJ; Hwang, SW; Kim, H; Kim, HS; Kim, M; Kim, YH; Lee, J; Pearce, LV; Thorat, SA; Turcios, NA, 2020) |
| "Hyperalgesia was induced by capsaicin and cinnamaldehyde on heat pain thresholds and by menthol on cold pain thresholds (Cohen d=2." | 2.90 | TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers. ( Lötsch, J; Weyer-Menkhoff, I, 2019) |
| "The area of mechanical pin-prick hyperalgesia was quantified." | 2.79 | Topical high-concentration menthol: reproducibility of a human surrogate pain model. ( Baron, R; Binder, A; Hüllemann, P; Mahn, F; Wasner, G, 2014) |
| "Current treatment strategies for painful diabetic neuropathy (PDN) include oral medications, which are costly and may have adverse effects." | 2.78 | Nutmeg extracts for painful diabetic neuropathy: a randomized, double-blind, controlled study. ( Maharaj, RG; Motilal, S, 2013) |
| "The use of topiceuticals in localized neuropathic pain associated with malignancy remain a valuable option with many advantages over systemic treatments." | 2.55 | The role of topiceuticals in cancer pain. ( Paisley, P; Serpell, M, 2017) |
| "Effective treatment of neuropathic pain without unacceptable side effects is challenging." | 1.42 | Cancer treatment-related neuropathic pain: proof of concept study with menthol--a TRPM8 agonist. ( Colvin, LA; Fallon, MT; Fleetwood-Walker, SM; Krishan, A; Mitchell, R; Scott, AC; Storey, DJ; Weir, CJ, 2015) |
| "Menthol was applied topically to the hind paws of naive and spinal nerve-ligated (SNL) rats." | 1.40 | Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol. ( Brice, NL; Dickenson, AH; Gonçalves, L; Hendrick, A; Leveridge, M; Mack, SR; Patel, R, 2014) |
| "When menthol was administered to ION-CCI rats, total contact time was further reduced and total contact number increased at the cooling temperatures." | 1.39 | Operant behavioral responses to orofacial cold stimuli in rats with chronic constrictive trigeminal nerve injury: effects of menthol and capsazepine. ( Gu, JG; Ling, JX; Xu, GY; Zuo, X, 2013) |
| "Menthol has previously been suggested as a model for hypersensitivity, but it has not yet been investigated if different levels of neuropathic pain may influence the effects of menthol or if topical application of menthol may act as a model for hypersensitivity in patients with phantom limb pain." | 1.39 | The effects of menthol on cold allodynia and wind-up-like pain in upper limb amputees with different levels of phantom limb pain. ( Arendt-Nielsen, L; Jensen, TS; Nikolajsen, L; Svensson, P; Vase, L, 2013) |
| "Both treatments resulted in cold and mechanical allodynia." | 1.38 | Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats. ( Aoki, M; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K, 2012) |
| "Central neuropathic pain following lesions within the CNS, such as spinal cord injury, is one of the most excruciating types of chronic pain and one of the most difficult to treat." | 1.35 | Residual spinothalamic tract pathways predict development of central pain after spinal cord injury. ( Engel, S; Lee, BB; McLachlan, E; Wasner, G, 2008) |
| "In eight neuropathic pain patients (six of peripheral, two of central origin), 40% menthol was applied topically to an area of preexisting cold allodynia." | 1.35 | The effect of menthol on cold allodynia in patients with neuropathic pain. ( Baron, R; Binder, A; McLachlan, EM; Naleschinski, D; Schattschneider, J; Wasner, G, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 13 (68.42) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Ann, J | 1 |
| Kim, HS | 1 |
| Thorat, SA | 1 |
| Kim, H | 1 |
| Ha, HJ | 1 |
| Choi, K | 1 |
| Kim, YH | 1 |
| Kim, M | 1 |
| Hwang, SW | 1 |
| Pearce, LV | 1 |
| Esch, TE | 1 |
| Turcios, NA | 1 |
| Blumberg, PM | 1 |
| Lee, J | 1 |
| Argôlo, IPR | 1 |
| Parisi, JR | 1 |
| Silva, JRTD | 1 |
| Silva, MLD | 1 |
| Paisley, P | 1 |
| Serpell, M | 1 |
| Weyer-Menkhoff, I | 1 |
| Lötsch, J | 1 |
| Zuo, X | 1 |
| Ling, JX | 1 |
| Xu, GY | 1 |
| Gu, JG | 1 |
| Andersen, HH | 1 |
| Olsen, RV | 1 |
| Møller, HG | 1 |
| Eskelund, PW | 1 |
| Gazerani, P | 1 |
| Arendt-Nielsen, L | 2 |
| Mahn, F | 1 |
| Hüllemann, P | 1 |
| Wasner, G | 3 |
| Baron, R | 2 |
| Binder, A | 2 |
| Patel, R | 1 |
| Gonçalves, L | 1 |
| Leveridge, M | 1 |
| Mack, SR | 1 |
| Hendrick, A | 1 |
| Brice, NL | 1 |
| Dickenson, AH | 1 |
| Fallon, MT | 1 |
| Storey, DJ | 1 |
| Krishan, A | 1 |
| Weir, CJ | 1 |
| Mitchell, R | 2 |
| Fleetwood-Walker, SM | 2 |
| Scott, AC | 1 |
| Colvin, LA | 1 |
| Brid, T | 1 |
| Miranda, G | 1 |
| Lozano, B | 1 |
| Baamonde, A | 1 |
| Lee, BB | 1 |
| Engel, S | 1 |
| McLachlan, E | 1 |
| Pan, R | 1 |
| Tian, Y | 1 |
| Gao, R | 1 |
| Li, H | 1 |
| Zhao, X | 1 |
| Barrett, JE | 1 |
| Hu, H | 1 |
| Aoki, M | 1 |
| Mori, A | 1 |
| Nakahara, T | 1 |
| Sakamoto, K | 1 |
| Ishii, K | 1 |
| Motilal, S | 1 |
| Maharaj, RG | 1 |
| Journigan, VB | 1 |
| Zaveri, NT | 1 |
| Vase, L | 1 |
| Svensson, P | 1 |
| Nikolajsen, L | 1 |
| Jensen, TS | 1 |
| Proudfoot, CJ | 1 |
| Garry, EM | 1 |
| Cottrell, DF | 1 |
| Rosie, R | 1 |
| Anderson, H | 1 |
| Robertson, DC | 1 |
| Naleschinski, D | 1 |
| Schattschneider, J | 1 |
| McLachlan, EM | 1 |
| Lotz, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| High-concentration L-menthol as a Counter-irritant to TRPA1-induced Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde[NCT02653703] | 14 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for menthol and Nerve Pain
| Article | Year |
|---|---|
The role of topiceuticals in cancer pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Local; Cancer Pain; Capsaicin; Clinical | 2017 |
A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia.
Topics: Animals; Humans; Hyperalgesia; Menthol; Neuralgia; Pain Measurement; Pain Threshold; Translational R | 2014 |
TRPM8 ion channel ligands for new therapeutic applications and as probes to study menthol pharmacology.
Topics: Animals; Antineoplastic Agents; Cold Temperature; Female; Humans; Inflammation; Ligands; Male; Menth | 2013 |
3 trials available for menthol and Nerve Pain
| Article | Year |
|---|---|
TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers.
Topics: Acrolein; Adult; Capsaicin; Cold Temperature; Cross-Over Studies; Female; Healthy Volunteers; Hot Te | 2019 |
Topical high-concentration menthol: reproducibility of a human surrogate pain model.
Topics: Adult; Antipruritics; Female; Healthy Volunteers; Humans; Hyperalgesia; Male; Menthol; Middle Aged; | 2014 |
Nutmeg extracts for painful diabetic neuropathy: a randomized, double-blind, controlled study.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Analgesics; Diabetic Neuropathies; Double-B | 2013 |
13 other studies available for menthol and Nerve Pain
| Article | Year |
|---|---|
Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.
Topics: Analgesics; Animals; Capsaicin; CHO Cells; Cricetulus; Drug Discovery; Hyperalgesia; Mice, Inbred IC | 2020 |
Participation of Potential Transient Receptors in the Antinociceptive Effect of Pharmacopuncture.
Topics: Acupuncture; Analgesics; Animals; Capsaicin; Male; Menthol; Neuralgia; Pain Measurement; Rats; Rats, | 2022 |
Operant behavioral responses to orofacial cold stimuli in rats with chronic constrictive trigeminal nerve injury: effects of menthol and capsazepine.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Conditioning, Operant; Facial Nerve; Facial | 2013 |
Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol.
Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Hyperalgesia; Male; Menthol; Morpholi | 2014 |
Cancer treatment-related neuropathic pain: proof of concept study with menthol--a TRPM8 agonist.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Analgesics; Antineoplastic Agents; Female; | 2015 |
Topical L-menthol for Postradiotherapy Neuropathic Pain: A Case Report.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Breast Neoplasms; Carcinoma, Ductal, Breast; Fema | 2015 |
Residual spinothalamic tract pathways predict development of central pain after spinal cord injury.
Topics: Adult; Capsaicin; Cold Temperature; Female; Histamine; Hot Temperature; Humans; Male; Menthol; Middl | 2008 |
Central mechanisms of menthol-induced analgesia.
Topics: Action Potentials; Analgesia; Animals; Behavior, Animal; Brain; Calcium Channel Blockers; Calcium Ch | 2012 |
Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats.
Topics: Analgesics; Animals; Antineoplastic Agents; Behavior, Animal; Calcitonin; Cold Temperature; Hyperalg | 2012 |
The effects of menthol on cold allodynia and wind-up-like pain in upper limb amputees with different levels of phantom limb pain.
Topics: Administration, Topical; Adult; Aged; Cold Temperature; Female; Humans; Hyperalgesia; Male; Menthol; | 2013 |
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
Topics: Acrolein; Amino Acids; Analgesia; Analysis of Variance; Animals; Blotting, Western; Cold Temperature | 2006 |
The effect of menthol on cold allodynia in patients with neuropathic pain.
Topics: Adult; Aged; Cold Temperature; Female; Humans; Hyperesthesia; Male; Menthol; Middle Aged; Neuralgia; | 2008 |
[Therapeutic experiences with Dolo-Menthoneuringel].
Topics: Back Pain; Drug Combinations; Evaluation Studies as Topic; Gels; Heparin; Humans; Menthol; Neuralgia | 1973 |