menthol has been researched along with Dry Eye Syndromes in 9 studies
Menthol: A monoterpene cyclohexanol produced from mint oils.
Dry Eye Syndromes: Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the sensitivity of corneal cold receptors to a known transient receptor potential melastatin 8 (TRPM8) agonist, menthol, in dry eye and normals, and to determine whether factors such as disease duration or age affect responses." | 9.24 | Dynamic Sensitivity of Corneal TRPM8 Receptors to Menthol Instillation in Dry Eye Versus Normal Subjects. ( Abelson, MB; Angjeli, E; Corcoran, P; Hollander, DA; Lane, K; Ousler, GW; Rimmer, D, 2017) |
| "To evaluate the role of transient receptor potential melastatin 8 (TRPM8) activity in menthol-induced cold sensitivity and its qualitative perception in patients with dry eye (DE)." | 8.02 | Role of transient receptor potential melastatin 8 activity in menthol-induced cold sensitivity and its qualitative perception in dry eye. ( Inoue, S; Ishida, R; Kaido, M; Kawashima, M; Nakamura, S; Tsubota, K, 2021) |
| " Previously, we have shown that dry eye, induced by lacrimal gland excision (LGE) in rats, sensitized corneal cool cells to the transient receptor potential melastatin 8 (TRPM8) agonist menthol and to cool stimulation." | 7.91 | Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1. ( Fujii, N; Hatta, A; Kurose, M; Meng, ID; Okamoto, K; Sullivan, C; Yamamura, K, 2019) |
| "To evaluate the effects of menthol-containing artificial tears on tear stimulation and ocular surface integrity in normal and dry eye rat models." | 7.88 | Effects of Menthol-Containing Artificial Tears on Tear Stimulation and Ocular Surface Integrity in Normal and Dry Eye Rat Models. ( Ahn, S; Eom, Y; Kang, B; Kim, HM; Lee, HK; Park, J; Song, JS, 2018) |
| "To assess the sensitivity of corneal cold receptors to a known transient receptor potential melastatin 8 (TRPM8) agonist, menthol, in dry eye and normals, and to determine whether factors such as disease duration or age affect responses." | 5.24 | Dynamic Sensitivity of Corneal TRPM8 Receptors to Menthol Instillation in Dry Eye Versus Normal Subjects. ( Abelson, MB; Angjeli, E; Corcoran, P; Hollander, DA; Lane, K; Ousler, GW; Rimmer, D, 2017) |
| "To evaluate the role of transient receptor potential melastatin 8 (TRPM8) activity in menthol-induced cold sensitivity and its qualitative perception in patients with dry eye (DE)." | 4.02 | Role of transient receptor potential melastatin 8 activity in menthol-induced cold sensitivity and its qualitative perception in dry eye. ( Inoue, S; Ishida, R; Kaido, M; Kawashima, M; Nakamura, S; Tsubota, K, 2021) |
| " Previously, we have shown that dry eye, induced by lacrimal gland excision (LGE) in rats, sensitized corneal cool cells to the transient receptor potential melastatin 8 (TRPM8) agonist menthol and to cool stimulation." | 3.91 | Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1. ( Fujii, N; Hatta, A; Kurose, M; Meng, ID; Okamoto, K; Sullivan, C; Yamamura, K, 2019) |
| "To evaluate the effects of menthol-containing artificial tears on tear stimulation and ocular surface integrity in normal and dry eye rat models." | 3.88 | Effects of Menthol-Containing Artificial Tears on Tear Stimulation and Ocular Surface Integrity in Normal and Dry Eye Rat Models. ( Ahn, S; Eom, Y; Kang, B; Kim, HM; Lee, HK; Park, J; Song, JS, 2018) |
| "Lacrimal gland excision (LGE) induced dry eye produces more severe corneal damage in female mice, yet signs of LGE-induced ocular pain and anxiety in male and female mice have not been characterized." | 1.56 | Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors. ( Demers, D; Denis, TE; Kalliel, JR; Mecum, NE; Meng, ID; Sullivan, CE, 2020) |
| "Some dry eye disease (DED) patients have sensitized responses to corneal stimulation, while others experience hypoalgesia." | 1.42 | Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease. ( Aicher, SA; Hegarty, DM; Hermes, SM, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Mecum, NE | 1 |
| Demers, D | 1 |
| Sullivan, CE | 1 |
| Denis, TE | 1 |
| Kalliel, JR | 1 |
| Meng, ID | 2 |
| Kaido, M | 1 |
| Inoue, S | 1 |
| Kawashima, M | 1 |
| Ishida, R | 1 |
| Nakamura, S | 1 |
| Tsubota, K | 2 |
| Arita, R | 1 |
| Morishige, N | 1 |
| Sakamoto, I | 1 |
| Imai, N | 1 |
| Shimada, Y | 1 |
| Igaki, M | 1 |
| Suzuki, A | 1 |
| Itoh, K | 1 |
| Corcoran, P | 1 |
| Hollander, DA | 1 |
| Ousler, GW | 1 |
| Angjeli, E | 1 |
| Rimmer, D | 1 |
| Lane, K | 1 |
| Abelson, MB | 1 |
| Ahn, S | 1 |
| Eom, Y | 1 |
| Kang, B | 1 |
| Park, J | 1 |
| Lee, HK | 1 |
| Kim, HM | 1 |
| Song, JS | 1 |
| Hatta, A | 1 |
| Kurose, M | 1 |
| Sullivan, C | 1 |
| Okamoto, K | 1 |
| Fujii, N | 1 |
| Yamamura, K | 1 |
| Aicher, SA | 1 |
| Hermes, SM | 1 |
| Hegarty, DM | 1 |
| Chen, GL | 1 |
| Lei, M | 1 |
| Zhou, LP | 1 |
| Zeng, B | 1 |
| Zou, F | 1 |
| Parra, A | 1 |
| Madrid, R | 1 |
| Echevarria, D | 1 |
| del Olmo, S | 1 |
| Morenilla-Palao, C | 1 |
| Acosta, MC | 1 |
| Gallar, J | 1 |
| Dhaka, A | 1 |
| Viana, F | 1 |
| Belmonte, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-Label, Single-Center Study to Evaluate Symptom Response and Tear Film Cooling Dynamics of Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra)[NCT02985827] | Phase 4 | 48 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants completed the cooling scale after receiving 1 dose of Rohto (r) Hydra at 6 time points (0, 0.5, 1, 2, 3, and 4 minutes post-treatment), and the scores were summed across these time points. The cooling scale was on a scale of 0 to 10, where 0=not cool and 10=very cool. The summed total was on a scale of 0= not cool and 60=very cool. (NCT02985827)
Timeframe: 4 Minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Dry Eye Participants | 24.6 |
| Normal Participants | 12.1 |
Participants completed the cooling scale after receiving 1 dose of Systane (r) Ultra at 6 time points (0, 0.5, 1, 2, 3, and 4 minutes post-treatment), and the scores were summed across these time points. The cooling scale was on a scale of 0 to 10, where 0=not cool and 10=very cool. The summed total was on a scale of 0= not cool and 60=very cool. (NCT02985827)
Timeframe: 4 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Dry Eye Participants | 12.6 |
| Normal Participants | 5.2 |
1 trial available for menthol and Dry Eye Syndromes
| Article | Year |
|---|---|
Dynamic Sensitivity of Corneal TRPM8 Receptors to Menthol Instillation in Dry Eye Versus Normal Subjects.
Topics: Administration, Ophthalmic; Adult; Aged; Antipruritics; Cornea; Cross-Over Studies; Double-Blind Met | 2017 |
8 other studies available for menthol and Dry Eye Syndromes
| Article | Year |
|---|---|
Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors.
Topics: Animals; Anxiety; Capsaicin; Dry Eye Syndromes; Eye Pain; Female; Lacrimal Apparatus; Male; Menthol; | 2020 |
Role of transient receptor potential melastatin 8 activity in menthol-induced cold sensitivity and its qualitative perception in dry eye.
Topics: Aged; Cross-Sectional Studies; Dry Eye Syndromes; Humans; Menthol; Middle Aged; Perception; Prospect | 2021 |
Effects of a warm compress containing menthol on the tear film in healthy subjects and dry eye patients.
Topics: Adult; Cornea; Dry Eye Syndromes; Eyelids; Female; Healthy Volunteers; Humans; Male; Menthol; Middle | 2017 |
Effects of Menthol-Containing Artificial Tears on Tear Stimulation and Ocular Surface Integrity in Normal and Dry Eye Rat Models.
Topics: Animals; Antipruritics; Conjunctiva; Cornea; Disease Models, Animal; Drug Combinations; Dry Eye Synd | 2018 |
Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1.
Topics: Animals; Capsaicin; Cornea; Dry Eye Syndromes; Electrophysiological Phenomena; Lacrimal Apparatus; M | 2019 |
Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease.
Topics: Animals; Capsaicin; Cornea; Denervation; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2015 |
Borneol Is a TRPM8 Agonist that Increases Ocular Surface Wetness.
Topics: Animals; Calcium; Camphanes; Cell Survival; Cells, Cultured; Dry Eye Syndromes; Electrophysiological | 2016 |
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea.
Topics: 4-Aminopyridine; Animals; Cold Temperature; Cornea; Dry Eye Syndromes; Menthol; Mice; Mice, Transgen | 2010 |