menthol has been researched along with Disease Models, Animal in 28 studies
Menthol: A monoterpene cyclohexanol produced from mint oils.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To screen potent terpenoid compounds against allergic inflammation in vitro and in vivo, five terpenoid compounds including menthone, farnesol, oridonin, β-escin and lupeol, were first selected to compare their anti-allergic inflammation potential using mouse lung mast cells in vitro." | 8.12 | Menthone supplementation protects from allergic inflammation in the lungs of asthmatic mice. ( Lin, JY; Su, YH, 2022) |
| "In conclusion, our results suggest that dietary menthol can protect against inflammation and cardiac remodeling after MI through activation of TRPM8." | 7.96 | Dietary Menthol Attenuates Inflammation and Cardiac Remodeling After Myocardial Infarction via the Transient Receptor Potential Melastatin 8. ( Chen, K; Peng, K; Tang, B; Wang, Q; Wang, Z; Yang, D; Yang, P; Yang, Y, 2020) |
| "To evaluate the effects of menthol-containing artificial tears on tear stimulation and ocular surface integrity in normal and dry eye rat models." | 7.88 | Effects of Menthol-Containing Artificial Tears on Tear Stimulation and Ocular Surface Integrity in Normal and Dry Eye Rat Models. ( Ahn, S; Eom, Y; Kang, B; Kim, HM; Lee, HK; Park, J; Song, JS, 2018) |
| "Menthol inhibited phototoxicity-evoked APs and reduced pain behavior when applied topically to mice." | 5.48 | Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. ( Baptista-Hon, D; Bull, F; Dalgaty, F; Gallacher, M; Hales, TG; Ibbotson, SH; Wright, L, 2018) |
| "Menthol is an aromatic compound with high antiinflammatory activity." | 5.46 | The effect of menthol on acute experimental colitis in rats. ( Bozorgi, H; Ghasemi-Pirbaluti, M; Motaghi, E, 2017) |
| "Therapy against anisakiasis requires invasive techniques to extract L3 , and an effective drug against this nematode is needed." | 5.40 | Peppermint (Mentha piperita) and albendazole against anisakiasis in an animal model. ( Martín-Sánchez, J; Navarro, MC; Romero, MC; Valero, A, 2014) |
| "To screen potent terpenoid compounds against allergic inflammation in vitro and in vivo, five terpenoid compounds including menthone, farnesol, oridonin, β-escin and lupeol, were first selected to compare their anti-allergic inflammation potential using mouse lung mast cells in vitro." | 4.12 | Menthone supplementation protects from allergic inflammation in the lungs of asthmatic mice. ( Lin, JY; Su, YH, 2022) |
| "In conclusion, our results suggest that dietary menthol can protect against inflammation and cardiac remodeling after MI through activation of TRPM8." | 3.96 | Dietary Menthol Attenuates Inflammation and Cardiac Remodeling After Myocardial Infarction via the Transient Receptor Potential Melastatin 8. ( Chen, K; Peng, K; Tang, B; Wang, Q; Wang, Z; Yang, D; Yang, P; Yang, Y, 2020) |
| "To evaluate the effects of menthol-containing artificial tears on tear stimulation and ocular surface integrity in normal and dry eye rat models." | 3.88 | Effects of Menthol-Containing Artificial Tears on Tear Stimulation and Ocular Surface Integrity in Normal and Dry Eye Rat Models. ( Ahn, S; Eom, Y; Kang, B; Kim, HM; Lee, HK; Park, J; Song, JS, 2018) |
| "Methotrexate (MTX) is indicated in the symptomatic control of severe, recalcitrant, and disabling psoriasis." | 3.77 | Efficacy study of vesicular gel containing methotrexate and menthol combination on parakeratotic rat skin model. ( Goyal, AK; Kesarla, R; Murthy, RR; Nagle, A, 2011) |
| "The cold- and menthol-sensitive receptor TRPM8 (transient receptor potential melastatin 8) has been suggested to play a role in cold allodynia, an intractable pain seen clinically." | 3.74 | TRPM8 mechanism of cold allodynia after chronic nerve injury. ( Chen, M; Gu, JG; Ling, J; Tan, W; Xing, H, 2007) |
| "Morphine was administered intramuscularly immediately prior to algogen administration." | 1.51 | Nociceptive-like behavior and analgesia in silver catfish (Rhamdia quelen). ( Baldisserotto, B; Barbosa, LB; Bianchini, AE; Ferrari, FT; Heinzmann, BM; Rodrigues, P, 2019) |
| "Menthol inhibited phototoxicity-evoked APs and reduced pain behavior when applied topically to mice." | 1.48 | Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. ( Baptista-Hon, D; Bull, F; Dalgaty, F; Gallacher, M; Hales, TG; Ibbotson, SH; Wright, L, 2018) |
| "Menthol is an aromatic compound with high antiinflammatory activity." | 1.46 | The effect of menthol on acute experimental colitis in rats. ( Bozorgi, H; Ghasemi-Pirbaluti, M; Motaghi, E, 2017) |
| "Some dry eye disease (DED) patients have sensitized responses to corneal stimulation, while others experience hypoalgesia." | 1.42 | Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease. ( Aicher, SA; Hegarty, DM; Hermes, SM, 2015) |
| "However, the role of TRPM8 in visceral hyperalgesia is poorly understood in pathological states such as inflammatory bowel disease." | 1.40 | TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice. ( Fujino, H; Horie, S; Hosoya, T; Matsumoto, K; Murayama, T; Nakamura, H; Tashima, K, 2014) |
| "Menthol was applied topically to the hind paws of naive and spinal nerve-ligated (SNL) rats." | 1.40 | Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol. ( Brice, NL; Dickenson, AH; Gonçalves, L; Hendrick, A; Leveridge, M; Mack, SR; Patel, R, 2014) |
| "Therapy against anisakiasis requires invasive techniques to extract L3 , and an effective drug against this nematode is needed." | 1.40 | Peppermint (Mentha piperita) and albendazole against anisakiasis in an animal model. ( Martín-Sánchez, J; Navarro, MC; Romero, MC; Valero, A, 2014) |
| "Depression was addressed by forced swimming test and smell function was evaluated by smelling different concentrations of menthol." | 1.36 | Abnormal olfactory function demonstrated by manganese-enhanced MRI in mice with experimental neuropsychiatric lupus. ( Agmon-Levin, N; Blank, M; Chapman, J; Kivity, S; Konen, E; Kushnir, T; Manor, D; Reichlin, M; Shoenfeld, Y; Tsarfaty, G; Wasson, C, 2010) |
| "Hypersensitivity was also observed with or without prior bladder distention, although the magnitude of electromyogram responses during ice water testing significantly correlated with the magnitude of electromyogram responses to bladder distention." | 1.35 | Ice water testing reveals hypersensitivity in adult rats that experienced neonatal bladder inflammation: implications for painful bladder syndrome/interstitial cystitis. ( Mebane, H; Ness, TJ; Randich, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 16 (57.14) | 24.3611 |
| 2020's | 7 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goodnough, CL | 1 |
| Wu, Y | 2 |
| Gross, ER | 1 |
| Kaur, J | 1 |
| Kumar, V | 2 |
| Shafi, S | 1 |
| Khare, P | 1 |
| Mahajan, N | 1 |
| Bhadada, SK | 1 |
| Kondepudi, KK | 1 |
| Bhunia, RK | 1 |
| Kuhad, A | 1 |
| Bishnoi, M | 1 |
| Su, YH | 1 |
| Lin, JY | 1 |
| Wang, Z | 2 |
| Sun, Y | 1 |
| Lou, F | 1 |
| Bai, J | 1 |
| Zhou, H | 1 |
| Cai, X | 1 |
| Sun, L | 1 |
| Yin, Q | 1 |
| Tang, S | 1 |
| Fan, L | 1 |
| Xu, Z | 1 |
| Wang, H | 2 |
| Hu, X | 1 |
| Rodrigues, P | 1 |
| Barbosa, LB | 1 |
| Bianchini, AE | 1 |
| Ferrari, FT | 1 |
| Baldisserotto, B | 1 |
| Heinzmann, BM | 1 |
| Wang, Q | 2 |
| Yang, Y | 2 |
| Chen, K | 1 |
| Tang, B | 1 |
| Peng, K | 1 |
| Yang, P | 1 |
| Yang, D | 1 |
| Taylor, DJR | 1 |
| Hamid, SM | 1 |
| Andres, AM | 1 |
| Saadaeijahromi, H | 1 |
| Piplani, H | 1 |
| Germano, JF | 1 |
| Song, Y | 1 |
| Sawaged, S | 1 |
| Feuer, R | 1 |
| Pandol, SJ | 1 |
| Sin, J | 1 |
| Du, J | 1 |
| Liu, D | 1 |
| Zhang, X | 1 |
| Zhou, A | 1 |
| Su, Y | 1 |
| He, D | 1 |
| Fu, S | 1 |
| Gao, F | 1 |
| Ghasemi-Pirbaluti, M | 1 |
| Motaghi, E | 1 |
| Bozorgi, H | 1 |
| Wright, L | 1 |
| Baptista-Hon, D | 1 |
| Bull, F | 1 |
| Dalgaty, F | 1 |
| Gallacher, M | 1 |
| Ibbotson, SH | 1 |
| Hales, TG | 1 |
| Palkar, R | 1 |
| Ongun, S | 1 |
| Catich, E | 1 |
| Li, N | 1 |
| Borad, N | 1 |
| Sarkisian, A | 1 |
| McKemy, DD | 1 |
| Ahn, S | 1 |
| Eom, Y | 1 |
| Kang, B | 1 |
| Park, J | 1 |
| Lee, HK | 1 |
| Kim, HM | 1 |
| Song, JS | 1 |
| Mizuno, K | 1 |
| Kono, T | 1 |
| Suzuki, Y | 1 |
| Miyagi, C | 1 |
| Omiya, Y | 1 |
| Miyano, K | 1 |
| Kase, Y | 1 |
| Uezono, Y | 1 |
| Hosoya, T | 1 |
| Matsumoto, K | 1 |
| Tashima, K | 1 |
| Nakamura, H | 1 |
| Fujino, H | 1 |
| Murayama, T | 1 |
| Horie, S | 1 |
| Patel, R | 1 |
| Gonçalves, L | 1 |
| Leveridge, M | 1 |
| Mack, SR | 1 |
| Hendrick, A | 1 |
| Brice, NL | 1 |
| Dickenson, AH | 1 |
| Romero, MC | 1 |
| Navarro, MC | 1 |
| Martín-Sánchez, J | 1 |
| Valero, A | 1 |
| Aicher, SA | 2 |
| Hermes, SM | 2 |
| Hegarty, DM | 2 |
| Zhang, L | 1 |
| An, X | 1 |
| He, M | 1 |
| Yang, K | 1 |
| Randich, A | 1 |
| Mebane, H | 1 |
| Ness, TJ | 1 |
| Kivity, S | 1 |
| Tsarfaty, G | 1 |
| Agmon-Levin, N | 1 |
| Blank, M | 1 |
| Manor, D | 1 |
| Konen, E | 1 |
| Chapman, J | 1 |
| Reichlin, M | 1 |
| Wasson, C | 1 |
| Shoenfeld, Y | 1 |
| Kushnir, T | 1 |
| Nagle, A | 1 |
| Goyal, AK | 1 |
| Kesarla, R | 1 |
| Murthy, RR | 1 |
| Xu, X | 1 |
| Yu, N | 1 |
| Bai, Z | 1 |
| Xun, Y | 1 |
| Jin, D | 1 |
| Li, Z | 1 |
| Cui, H | 1 |
| Bhadania, M | 1 |
| Joshi, H | 1 |
| Patel, P | 1 |
| Kulkarni, VH | 1 |
| Xing, H | 1 |
| Chen, M | 1 |
| Ling, J | 1 |
| Tan, W | 1 |
| Gu, JG | 1 |
| Santos, FA | 2 |
| Rao, VS | 2 |
| Silva, RM | 1 |
| Tomé, AR | 1 |
| Pompeu, MM | 1 |
| Teixeira, MJ | 1 |
| De Freitas, LA | 1 |
| De Souza, VL | 1 |
| Yu, D | 1 |
| Pearson, SK | 1 |
| Bowen, WH | 1 |
| Luo, D | 1 |
| Kohut, BE | 1 |
| Harper, DS | 1 |
28 other studies available for menthol and Disease Models, Animal
| Article | Year |
|---|---|
Topical analgesic BENGAY® reduces myocardial infarct size in rodents.
Topics: Administration, Topical; Analgesics; Animals; Disease Models, Animal; Male; Menthol; Myocardial Infa | 2021 |
Combination of TRP channel dietary agonists induces energy expending and glucose utilizing phenotype in HFD-fed mice.
Topics: Acrolein; Animals; Capsaicin; Diet, High-Fat; Disease Models, Animal; Energy Metabolism; Menthol; Mi | 2022 |
Menthone supplementation protects from allergic inflammation in the lungs of asthmatic mice.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Dietary Supplements; Disease Models, Anima | 2022 |
Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis.
Topics: Animals; Disease Models, Animal; Immunoglobulins; Keratinocytes; Menthol; Mice; Psoriasis; Transcrip | 2022 |
Nociceptive-like behavior and analgesia in silver catfish (Rhamdia quelen).
Topics: Acetic Acid; Analgesia; Analgesics, Opioid; Animals; Catfishes; Disease Models, Animal; Injections; | 2019 |
Dietary Menthol Attenuates Inflammation and Cardiac Remodeling After Myocardial Infarction via the Transient Receptor Potential Melastatin 8.
Topics: Animals; Anti-Inflammatory Agents; Diet; Disease Models, Animal; Fibrosis; Hemodynamics; Inflammatio | 2020 |
Antiviral Effects of Menthol on Coxsackievirus B.
Topics: Animals; Antiviral Agents; Cells, Cultured; Coxsackievirus Infections; Disease Models, Animal; Enter | 2020 |
Menthol protects dopaminergic neurons against inflammation-mediated damage in lipopolysaccharide (LPS)-Evoked model of Parkinson's disease.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Brain; Cell Line; Cytokines; Disease Models, An | 2020 |
The effect of menthol on acute experimental colitis in rats.
Topics: Acute Disease; Animals; Body Weight; Colitis; Colon; Cytokines; Disease Models, Animal; Hematocrit; | 2017 |
Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy.
Topics: Acrylamides; Animals; Animals, Newborn; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Derm | 2018 |
Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.
Topics: Animals; Antipruritics; Behavior, Animal; Capsaicin; Chloroquine; Chronic Disease; Cryotherapy; Dise | 2018 |
Effects of Menthol-Containing Artificial Tears on Tear Stimulation and Ocular Surface Integrity in Normal and Dry Eye Rat Models.
Topics: Animals; Antipruritics; Conjunctiva; Cornea; Disease Models, Animal; Drug Combinations; Dry Eye Synd | 2018 |
Goshajinkigan, a traditional Japanese medicine, prevents oxaliplatin-induced acute peripheral neuropathy by suppressing functional alteration of TRP channels in rat.
Topics: Acute Disease; Animals; Cold Temperature; Disease Models, Animal; Drugs, Chinese Herbal; Ganglia, Sp | 2014 |
TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice.
Topics: Anilides; Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Hyperalgesia; Male; Ment | 2014 |
Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol.
Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Hyperalgesia; Male; Menthol; Morpholi | 2014 |
Peppermint (Mentha piperita) and albendazole against anisakiasis in an animal model.
Topics: Albendazole; Animals; Anisakiasis; Anisakis; Disease Models, Animal; Female; Larva; Mentha piperita; | 2014 |
Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease.
Topics: Animals; Capsaicin; Cornea; Denervation; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2015 |
Activation of Cold-Sensitive Channels TRPM8 and TRPA1 Inhibits the Proliferative Airway Smooth Muscle Cell Phenotype.
Topics: Actins; Airway Remodeling; Animals; Asthma; Bronchi; Calcium Channel Agonists; Cell Movement; Cell P | 2016 |
Select noxious stimuli induce changes on corneal nerve morphology.
Topics: Animals; Capsaicin; Cornea; Disease Models, Animal; Imaging, Three-Dimensional; Immunohistochemistry | 2017 |
Ice water testing reveals hypersensitivity in adult rats that experienced neonatal bladder inflammation: implications for painful bladder syndrome/interstitial cystitis.
Topics: Administration, Intravesical; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Cystitis | 2009 |
Abnormal olfactory function demonstrated by manganese-enhanced MRI in mice with experimental neuropsychiatric lupus.
Topics: Animals; Autoantibodies; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Femal | 2010 |
Efficacy study of vesicular gel containing methotrexate and menthol combination on parakeratotic rat skin model.
Topics: Administration, Topical; Animals; Dermatologic Agents; Diffusion Chambers, Culture; Disease Models, | 2011 |
Effect of menthol on ocular drug delivery.
Topics: Animals; Aqueous Humor; Blood-Aqueous Barrier; Cornea; Dexamethasone; Disease Models, Animal; Drug D | 2011 |
Protective effect of menthol on β-amyloid peptide induced cognitive deficits in mice.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Behavior, Animal; Brain; Cognition Disorders; Disease | 2012 |
TRPM8 mechanism of cold allodynia after chronic nerve injury.
Topics: Animals; Capsaicin; Cells, Cultured; Chronic Disease; Cold Temperature; Disease Models, Animal; Fema | 2007 |
1,8-cineol, a food flavoring agent, prevents ethanol-induced gastric injury in rats.
Topics: Administration, Oral; Alcoholism; Animals; Antioxidants; Cyclohexanols; Disease Models, Animal; Drug | 2001 |
1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shock.
Topics: Animals; Cyclohexanols; Disease Models, Animal; Eucalyptol; Galactosamine; Lipopolysaccharides; Live | 2001 |
Caries inhibition efficacy of an antiplaque/antigingivitis dentifrice.
Topics: Analysis of Variance; Animals; Anti-Infective Agents, Local; Cariostatic Agents; Cyclohexanols; Dent | 2000 |