menthol has been researched along with Cough in 20 studies
Menthol: A monoterpene cyclohexanol produced from mint oils.
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with chronic cough, pre-inhalation of menthol reduces cough sensitivity to inhaled capsaicin and influences inspiratory flows." | 9.17 | Inhalation of menthol reduces capsaicin cough sensitivity and influences inspiratory flows in chronic cough. ( Bende, M; Millqvist, E; Ternesten-Hasséus, E, 2013) |
| "Inhalation of l-menthol inhibits cough and has been shown to reduce respiratory discomfort associated with loaded breathing." | 9.09 | [Does the inhalation of a 1% L-menthol solution in the premedication of fiberoptic bronchoscopy affect coughing and the sensation of dyspnea?]. ( Butnarasu, SJ; Haidl, P; Kemper, P; Klauke, M; Köhler, D; Wehde, H, 2001) |
| "Menthol is a commonly used ingredient in many over the counter cough remedies, but there is little objective evidence as to its efficacy." | 9.07 | Effect of inhaled menthol on citric acid induced cough in normal subjects. ( Grattan, TJ; Higgins, KS; Marshall, AE; Morice, AH, 1994) |
| "Lotussin and linctus diphenhydramine were compared for efficacy and patient preference in fifty patients suffering from post-infective cough." | 9.04 | A trial of Lotussin and linctus diphenhydramine in patients wth an irritant cough. ( Matts, SG, 1977) |
| "The authors report a highly probable and clinically relevant interaction between warfarin and the popular cough lozenges 'Fisherman's Friends' in a 67-year-old man, whereby ingestion of these lozenges for approximately 1 month was associated with a significant reduction in international normalised ratio to subtherapeutic levels." | 7.77 | Clinically significant interaction between warfarin and popular cough lozenges 'Fisherman's Friend'. ( Boyle, S; Walters, MR, 2011) |
| " The patient reported that he had been taking 8-10 menthol cough drops/day due to dry conditions at his workplace during the time period that the INR decreased." | 7.76 | Probable warfarin interaction with menthol cough drops. ( Coderre, K; Dyer, E; Faria, C, 2010) |
| "To report a case of possible interaction of menthol cough drops (Halls) with warfarin in a patient awaiting cardioversion." | 7.73 | Possible warfarin interaction with menthol cough drops. ( Kassebaum, PJ; Shaw, DL; Tomich, DJ, 2005) |
| "Cough is a vital protective reflex that is triggered by both mechanical and chemical stimuli." | 6.77 | Sweet taste and menthol increase cough reflex thresholds. ( Breslin, PA; Dalton, P; Wise, PM, 2012) |
| "Menthol has no effect on objective measures of flow but significantly increases the perception of nasal patency." | 6.73 | Does inhaling menthol affect nasal patency or cough? ( Beardsmore, C; Houghton, T; Kenia, P, 2008) |
| " The search terms used were 'TRP channel AND plant compound', 'cough AND plant compound', 'cough AND TRP channels AND plant compound', 'cough AND P2X3 AND plant compound' and 'P2X3 AND plant compound' where plant compound represents menthol or camphor or eucalyptus or turpentine or thymol." | 5.41 | Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies. ( Morice, AH; Sadofsky, LR; Stinson, RJ, 2023) |
| "To investigate the efficacy and safety of CS1002, an over-the-counter cough treatment containing diphenhydramine, ammonium chloride and levomenthol in a cocoa-based demulcent." | 5.24 | Rococo study: a real-world evaluation of an over-the-counter medicine in acute cough (a multicentre, randomised, controlled study). ( Birring, SS; Brew, J; Edwards, V; Kilbourn, A; Morice, AH; Wilson, R, 2017) |
| "In patients with chronic cough, pre-inhalation of menthol reduces cough sensitivity to inhaled capsaicin and influences inspiratory flows." | 5.17 | Inhalation of menthol reduces capsaicin cough sensitivity and influences inspiratory flows in chronic cough. ( Bende, M; Millqvist, E; Ternesten-Hasséus, E, 2013) |
| "Inhalation of l-menthol inhibits cough and has been shown to reduce respiratory discomfort associated with loaded breathing." | 5.09 | [Does the inhalation of a 1% L-menthol solution in the premedication of fiberoptic bronchoscopy affect coughing and the sensation of dyspnea?]. ( Butnarasu, SJ; Haidl, P; Kemper, P; Klauke, M; Köhler, D; Wehde, H, 2001) |
| "Menthol is a commonly used ingredient in many over the counter cough remedies, but there is little objective evidence as to its efficacy." | 5.07 | Effect of inhaled menthol on citric acid induced cough in normal subjects. ( Grattan, TJ; Higgins, KS; Marshall, AE; Morice, AH, 1994) |
| "Lotussin and linctus diphenhydramine were compared for efficacy and patient preference in fifty patients suffering from post-infective cough." | 5.04 | A trial of Lotussin and linctus diphenhydramine in patients wth an irritant cough. ( Matts, SG, 1977) |
| "Capsaicin, a TRPV1 agonist, stimulates both the cough and swallowing reflexes." | 4.93 | Chemical Senses Affecting Cough and Swallowing. ( Ebihara, S; Ebihara, T; Izukura, H; Miyagi, M; Okuni, I; Sekiya, H, 2016) |
| "The cold-sensitive cation channel TRPM8 is a target for menthol, which is used routinely as a cough suppressant and as an additive to tobacco and food products." | 3.79 | The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol. ( Brozmanova, M; Canning, BJ; Kollarik, M; Mori, N; Plevkova, J; Poliacek, I; Surdenikova, L; Tatar, M, 2013) |
| "The authors report a highly probable and clinically relevant interaction between warfarin and the popular cough lozenges 'Fisherman's Friends' in a 67-year-old man, whereby ingestion of these lozenges for approximately 1 month was associated with a significant reduction in international normalised ratio to subtherapeutic levels." | 3.77 | Clinically significant interaction between warfarin and popular cough lozenges 'Fisherman's Friend'. ( Boyle, S; Walters, MR, 2011) |
| " The patient reported that he had been taking 8-10 menthol cough drops/day due to dry conditions at his workplace during the time period that the INR decreased." | 3.76 | Probable warfarin interaction with menthol cough drops. ( Coderre, K; Dyer, E; Faria, C, 2010) |
| "Cough is a vital protective reflex that is triggered by both mechanical and chemical stimuli." | 2.77 | Sweet taste and menthol increase cough reflex thresholds. ( Breslin, PA; Dalton, P; Wise, PM, 2012) |
| "Menthol has no effect on objective measures of flow but significantly increases the perception of nasal patency." | 2.73 | Does inhaling menthol affect nasal patency or cough? ( Beardsmore, C; Houghton, T; Kenia, P, 2008) |
| "Codeine is not necessary in the treatment of cough." | 2.53 | [Drug therapy for cough]. ( Koskela, H; Naaranlahti, T, 2016) |
| " No serious adverse events were noted." | 1.31 | Efficacy and safety of Ascoril in the management of cough--National Study Group report. ( Ainapure, SS; Desai, A; Korde, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 10 (50.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stinson, RJ | 1 |
| Morice, AH | 4 |
| Sadofsky, LR | 1 |
| Plevkova, J | 1 |
| Kollarik, M | 1 |
| Poliacek, I | 1 |
| Brozmanova, M | 1 |
| Surdenikova, L | 1 |
| Tatar, M | 1 |
| Mori, N | 1 |
| Canning, BJ | 1 |
| D'Ruiz, CD | 1 |
| Graff, DW | 1 |
| Yan, XS | 1 |
| Ebihara, S | 1 |
| Izukura, H | 1 |
| Miyagi, M | 1 |
| Okuni, I | 1 |
| Sekiya, H | 1 |
| Ebihara, T | 1 |
| Koskela, H | 1 |
| Naaranlahti, T | 1 |
| Birring, SS | 1 |
| Brew, J | 1 |
| Kilbourn, A | 1 |
| Edwards, V | 1 |
| Wilson, R | 1 |
| Coderre, K | 1 |
| Faria, C | 1 |
| Dyer, E | 1 |
| Wise, PM | 1 |
| Breslin, PA | 1 |
| Dalton, P | 1 |
| Boyle, S | 1 |
| Walters, MR | 1 |
| Millqvist, E | 1 |
| Ternesten-Hasséus, E | 1 |
| Bende, M | 1 |
| Hasani, A | 1 |
| Pavia, D | 1 |
| Toms, N | 1 |
| Dilworth, P | 1 |
| Agnew, JE | 1 |
| Kassebaum, PJ | 1 |
| Shaw, DL | 1 |
| Tomich, DJ | 1 |
| Kenia, P | 1 |
| Houghton, T | 1 |
| Beardsmore, C | 1 |
| Laude, EA | 1 |
| Grattan, TJ | 2 |
| Marshall, AE | 1 |
| Higgins, KS | 1 |
| Haidl, P | 1 |
| Kemper, P | 1 |
| Butnarasu, SJ | 1 |
| Klauke, M | 1 |
| Wehde, H | 1 |
| Köhler, D | 1 |
| Ainapure, SS | 1 |
| Desai, A | 1 |
| Korde, K | 1 |
| Matts, SG | 1 |
| Ulmer, WT | 1 |
| Schött, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterization of Nicotine Exposure and Urge-to-Smoke Following a Single Controlled Administration and Short-Term Ad Lib Use of Electronic Cigarettes and Conventional Cigarettes in Adult Smokers[NCT02210754] | 24 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
| Application of Visual Laryngoscope-guided Tracheal Intubation in Lateral Position in Thoracic Surgery:A Prospective, Multicenter, Large Sample, Randomized Controlled Study[NCT05482230] | 300 participants (Anticipated) | Interventional | 2022-09-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for menthol and Cough
| Article | Year |
|---|---|
Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies.
Topics: Analgesics; Camphor; Cough; Humans; Menthol; Pain; Transient Receptor Potential Channels; TRPA1 Cati | 2023 |
Chemical Senses Affecting Cough and Swallowing.
Topics: Acids; Angiotensin-Converting Enzyme Inhibitors; Animals; Capsaicin; Cigarette Smoking; Cough; Deglu | 2016 |
[Drug therapy for cough].
Topics: Antitussive Agents; Codeine; Cough; Dextromethorphan; Histamine Antagonists; Honey; Humans; Leukotri | 2016 |
10 trials available for menthol and Cough
| Article | Year |
|---|---|
Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes.
Topics: Adult; Cough; Craving; Cross-Over Studies; Dizziness; Electronic Nicotine Delivery Systems; Female; | 2015 |
Rococo study: a real-world evaluation of an over-the-counter medicine in acute cough (a multicentre, randomised, controlled study).
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ammonium Chloride; Antipruritics; Cacao; | 2017 |
Sweet taste and menthol increase cough reflex thresholds.
Topics: Administration, Inhalation; Adult; Cough; Double-Blind Method; Female; Humans; Male; Menthol; Reflex | 2012 |
Inhalation of menthol reduces capsaicin cough sensitivity and influences inspiratory flows in chronic cough.
Topics: Administration, Inhalation; Adult; Aged; Antitussive Agents; Capsaicin; Chronic Disease; Cough; Doub | 2013 |
Effect of aromatics on lung mucociliary clearance in patients with chronic airways obstruction.
Topics: Aged; Aromatherapy; Bronchitis, Chronic; Camphor; Cough; Cross-Over Studies; Cyclohexanols; Eucalypt | 2003 |
Does inhaling menthol affect nasal patency or cough?
Topics: Administration, Inhalation; Antitussive Agents; Bronchial Provocation Tests; Child; Citric Acid; Cou | 2008 |
Effect of inhaled menthol on citric acid induced cough in normal subjects.
Topics: Administration, Inhalation; Adult; Antitussive Agents; Bronchial Provocation Tests; Citrates; Citric | 1994 |
[Does the inhalation of a 1% L-menthol solution in the premedication of fiberoptic bronchoscopy affect coughing and the sensation of dyspnea?].
Topics: Administration, Inhalation; Adult; Aged; Antitussive Agents; Atropine; Bronchoscopy; Cough; Double-B | 2001 |
A trial of Lotussin and linctus diphenhydramine in patients wth an irritant cough.
Topics: Ammonium Chloride; Antitussive Agents; Chloroform; Citrates; Clinical Trials as Topic; Cough; Dextro | 1977 |
[Chronic obstructive bronchitis. Effect of Gelomyrtol forte in a placebo-controlled double-blind study].
Topics: Cough; Cyclohexanols; Cyclohexenes; Double-Blind Method; Drug Combinations; Eucalyptol; Expectorants | 1991 |
7 other studies available for menthol and Cough
| Article | Year |
|---|---|
The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol.
Topics: Animals; Antitussive Agents; Cold Temperature; Cough; Guinea Pigs; Male; Menthol; Nasal Mucosa; Neur | 2013 |
[Good evidence for phytotherapy drugs].
Topics: Acute Disease; Bronchitis; Cough; Drug Combinations; Evidence-Based Medicine; Guideline Adherence; H | 2015 |
Probable warfarin interaction with menthol cough drops.
Topics: Anticoagulants; Black or African American; Cough; Drug Interactions; Humans; International Normalize | 2010 |
Clinically significant interaction between warfarin and popular cough lozenges 'Fisherman's Friend'.
Topics: Aged; Anticoagulants; Cough; Drug Interactions; Humans; International Normalized Ratio; Male; Mentho | 2011 |
Possible warfarin interaction with menthol cough drops.
Topics: Cough; Drug Interactions; Humans; International Normalized Ratio; Male; Menthol; Middle Aged; Warfar | 2005 |
The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs.
Topics: Administration, Inhalation; Animals; Antitussive Agents; Camphor; Citrates; Citric Acid; Cough; Cycl | 1994 |
Efficacy and safety of Ascoril in the management of cough--National Study Group report.
Topics: Adolescent; Adult; Aged; Bromhexine; Child; Child, Preschool; Cough; Drug Combinations; Expectorants | 2001 |