Page last updated: 2024-10-21

menthol and Colicky Pain

menthol has been researched along with Colicky Pain in 3 studies

Menthol: A monoterpene cyclohexanol produced from mint oils.

Research Excerpts

ExcerptRelevanceReference
"We examined the efficacy of the combined use of L-menthol spraying (L-mentholS) as an antispasmodic agent and carbon dioxide insufflation (CO2I) on the adenoma detection rate (ADR) in a prospective, single-center trial with a 2 × 2 factorial design."9.34Effects of L-Menthol and Carbon Dioxide on the Adenoma Detection Rate during Colonoscopy: L-Menthol and Carbon Dioxide on Colonoscopy. ( Endo, Y; Inoue, K; Itoh, Y; Kagawa, K; Katayama, T; Komaki, T; Minagawa, Y; Nagata, A; Naito, Y; Nakamura, H; Oka, K; Okuda, T; Ota, T; Sugino, S; Tsuji, T; Yasue, C, 2020)
"We examined the efficacy of the combined use of L-menthol spraying (L-mentholS) as an antispasmodic agent and carbon dioxide insufflation (CO2I) on the adenoma detection rate (ADR) in a prospective, single-center trial with a 2 × 2 factorial design."5.34Effects of L-Menthol and Carbon Dioxide on the Adenoma Detection Rate during Colonoscopy: L-Menthol and Carbon Dioxide on Colonoscopy. ( Endo, Y; Inoue, K; Itoh, Y; Kagawa, K; Katayama, T; Komaki, T; Minagawa, Y; Nagata, A; Naito, Y; Nakamura, H; Oka, K; Okuda, T; Ota, T; Sugino, S; Tsuji, T; Yasue, C, 2020)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's2 (66.67)2.80

Authors

AuthorsStudies
Shulman, RJ1
Chumpitazi, BP1
Abdel-Rahman, SM1
Garg, U1
Musaad, S1
Kearns, GL1
Weerts, ZZRM1
Keszthelyi, D1
Vork, L1
Aendekerk, NCP1
Frijlink, HW1
Brouwers, JRBJ1
Neef, C1
Jonkers, DMAE1
Masclee, AAM1
Inoue, K1
Okuda, T1
Oka, K1
Sugino, S1
Endo, Y1
Ota, T1
Minagawa, Y1
Yasue, C1
Tsuji, T1
Katayama, T1
Nakamura, H1
Nagata, A1
Komaki, T1
Naito, Y1
Itoh, Y1
Kagawa, K1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Peppermint Oil Pharmacokinetics/Dynamics and Novel Biological Signatures in Children With Functional Abdominal Pain[NCT03295747]Phase 130 participants (Actual)Interventional2017-10-15Completed
Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery[NCT02716285]Phase 3190 participants (Actual)Interventional2016-08-17Completed
A Randomized, Double Blind, Single Dose, Two Treatment, Two Period Crossover Pharmacokinetic Study Comparing a 182mg Colon-targeted-delivery Peppermint Oil Capsule (Tempocol-ColoPulse®) and a 182mg Enteric-coated Peppermint Oil Capsule (Tempocol®) in Heal[NCT02291445]Phase 28 participants (Actual)Interventional2015-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

AUC

Area under the plasma concentration-time curve from t=0 hrs until t=24 hrs. (NCT02291445)
Timeframe: 24 hours

Interventionug*h/L (Median)
Ileocolonic Release PO2331
Small Intestinal Release PO2623

C-max

Menthol-glucuronide (main constituent of peppermint oil after conversion by the liver) peak plasma concentrations (NCT02291445)
Timeframe: 24 hours

Interventionug/L (Median)
Ileocolonic Release PO563.6
Small Intestinal Release PO702

T-lag

Time until a measurable plasma concentration of menthol-glucuronide occurs after oral administration of peppermint oil (45ug/L) (NCT02291445)
Timeframe: 24 hours

Interventionminutes (Median)
Ileocolonic Release PO225
Small Intestinal Release PO37

T-max

Time to reach maximum menthol-glucuronide (main constituent of peppermint oil after conversion by the liver) concentration in plasma (NCT02291445)
Timeframe: 24 hours

Interventionminutes (Median)
Ileocolonic Release PO360
Small Intestinal Release PO180

T1/2

elimination half-life; time required for the plasma concentration of menthol-glucuronide to reach half of its original value. (NCT02291445)
Timeframe: 24 hours

Interventionhours (Median)
Ileocolonic Release PO6.1
Small Intestinal Release PO7.7

Trials

3 trials available for menthol and Colicky Pain

ArticleYear
Randomised trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain.
    British journal of clinical pharmacology, 2022, Volume: 88, Issue:3

    Topics: Abdominal Pain; Child; Humans; Intestine, Small; Mentha piperita; Menthol; Plant Oils

2022
A Novel Ileocolonic Release Peppermint Oil Capsule for Treatment of Irritable Bowel Syndrome: A Phase I Study in Healthy Volunteers.
    Advances in therapy, 2018, Volume: 35, Issue:11

    Topics: Abdominal Pain; Adult; Biological Availability; Capsules; Cross-Over Studies; Double-Blind Method; F

2018
A Novel Ileocolonic Release Peppermint Oil Capsule for Treatment of Irritable Bowel Syndrome: A Phase I Study in Healthy Volunteers.
    Advances in therapy, 2018, Volume: 35, Issue:11

    Topics: Abdominal Pain; Adult; Biological Availability; Capsules; Cross-Over Studies; Double-Blind Method; F

2018
A Novel Ileocolonic Release Peppermint Oil Capsule for Treatment of Irritable Bowel Syndrome: A Phase I Study in Healthy Volunteers.
    Advances in therapy, 2018, Volume: 35, Issue:11

    Topics: Abdominal Pain; Adult; Biological Availability; Capsules; Cross-Over Studies; Double-Blind Method; F

2018
A Novel Ileocolonic Release Peppermint Oil Capsule for Treatment of Irritable Bowel Syndrome: A Phase I Study in Healthy Volunteers.
    Advances in therapy, 2018, Volume: 35, Issue:11

    Topics: Abdominal Pain; Adult; Biological Availability; Capsules; Cross-Over Studies; Double-Blind Method; F

2018
Effects of L-Menthol and Carbon Dioxide on the Adenoma Detection Rate during Colonoscopy: L-Menthol and Carbon Dioxide on Colonoscopy.
    Digestion, 2020, Volume: 101, Issue:3

    Topics: Abdominal Pain; Adenoma; Adult; Aged; Aged, 80 and over; Carbon Dioxide; Colonoscopy; Colorectal Neo

2020