menotropins and Infant--Newborn--Diseases

Five quintuplet pregnancies, following induction of ovulation with clomiphene and HMG-HCG, are the subject of this communication. In 3 women, pregnancy was associated with ovarian overstimulation, and two patients required emergency surgery because of torsion of an ovarian cyst. Two women aborted in mid-trimester, while the other 3 delivered by cesarean section at 33-35 wk gestation. 15 babies were born, weighing 700-2200 g. 8 infants suffered from respiratory distress syndrome and 5 babies were born with correctable malformations. 13 newborns survived, and all are mentally and physically well-developed. Four of the 5 women conceived again. The management of the patients during multiple gestation and the outcome of pregnancy are discussed.

Topics: Clomiphene; Female; Gonadotropins, Pituitary; Humans; Infant, Newborn; Infant, Newborn, Diseases; Menotropins; Ovulation; Ovulation Induction; Pregnancy; Pregnancy Maintenance; Pregnancy, Multiple; Quintuplets; Sex Ratio