menotropins and Hydatidiform-Mole

A case of a triplet pregnancy involving a dizygous twin pregnancy and a complete hydatidiform mole after therapy with human menopausal gonadotropin and human chorionic gonadotropin is reported. Two female fetuses, two placentas in one mass with two amnions and two chorions, and a tumor mass with a grapelike appearance were spontaneously delivered at 19 weeks of gestation. The deoxyribonucleic acid fingerprints of the two placentas and tumor tissue were compared with those of the parents. The fingerprints of the placentas showed patterns different from each other; however, all their polymorphic fragments could be traced back to either the father or mother. All polymorphic fragments of the tumor tissue were inherited only from the father (androgenesis). These results indicated that this triplet pregnancy involved a dizygous twin pregnancy and a complete hydatidiform mole.

Topics: Adult; Chorionic Gonadotropin; DNA Fingerprinting; Female; Humans; Hydatidiform Mole; Infant, Newborn; Menotropins; Ovulation Induction; Pregnancy; Pregnancy, Multiple; Twins, Dizygotic; Uterine Neoplasms

A case is presented of a twin gestation comprising a grossly normal fetus and placenta coexisting with a separate hydatidiform mole which ended in an abortion. Both developed following ovulation induction with human menopausal gonadotrophin and human chorionic gonadotrophin. The literature is reviewed and clinical aspects of this rare entity are discussed.

Topics: Abortion, Spontaneous; Chorionic Gonadotropin; Female; Humans; Hydatidiform Mole; Menotropins; Ovulation Induction; Pregnancy; Twins

Paternal dispermy can be the pathogenesis of complete molar pregnancy.. A 23-year-old, white woman, gravida 4, para 1, was pregnant with a twin gestation by ovulation induction with metrodin. Ultrasound evaluation confirmed an intrauterine pregnancy in conjunction with what appeared to be a hydatidiform mole. The karyotype in the molar pregnancy, obtained from chorionic villus sampling, showed a pair of paternally derived inverted chromosomes 9, confirming the diagnosis of a complete mole. Uncontrollable hemorrhage with a rapid rise in the beta-human chorionic gonadotropin titer necessitated evacuation of the uterus. The patient was followed with beta-human chorionic gonadotropin titers for a year, with no evidence of recurrence.. This case illustrates paternal disomy in a complete molar pregnancy documented by a paternal chromosome 9 inversion.

Topics: Adult; Chorionic Gonadotropin, beta Subunit, Human; Chromosome Inversion; Chromosomes, Human, Pair 9; Diseases in Twins; Fathers; Female; Humans; Hydatidiform Mole; Menotropins; Ovulation Induction; Pregnancy; Prenatal Diagnosis; Twins

Although hydatidiform mole is not commonly encountered following ovulation induction, patients who have already had molar pregnancies are at increased risk of developing further molar diseases with worsening histologic characteristics. That fact underlies the ethical dilemma of repeat ovulation induction.. A 38-year-old woman, gravida 3, para 0, had three consecutive episodes of hydatidiform subsequent to clomiphene citrate and gonadotropin ovulation induction. She seems to be the first in the literature to develop three consecutive molar pregnancies without a normal intrauterine pregnancy.. Although ovulation induction commenced again in this patient after she gave informed consent, the risks underlying the ethical dilemma persist.

Topics: Adult; Clomiphene; Female; Humans; Hydatidiform Mole; Menotropins; Ovulation Induction; Pregnancy; Recurrence

The CA-125-antigen could not only be identified in the epithelium of serous ovarian carcinoma, but also in the regular surface epithelium of the endometrium, the decidua and the peritoneum. The aim of this study was, to examine the pattern of CA-125 in the serum of women at early stages of pregnancy, after hMG/hCG-stimulation and subsequent insemination, IVF or GIFT. In particular, it was differentiated between simple or twin pregnancies, ovarian hyperstimulation syndrome and mole pregnancies. 16 patients, who spontaneously became pregnant after cyclus-monitoring, served as a control group. Among the total of 77 patients, 16 women with single pregnancies without stimulation showed an increase of CA-125 values to maximum amounts of 42.9 +/- 18.8 U/ml in the 8th week. 21 patients with single pregnancies after hMG/hCG-treatment and IVF, exhibited maximums of 97.5 +/- 66.8 U/ml in the 6th week, in cases of twins (n = 10) of 216.8 +/- 85.1 U/ml in the 7th week. Considering the group with the hMG/hCG-stimulation and following insemination (n = 20), maximum values of 91.4 +/- 57.3 U/ml were found in the 6th week, just as in the IVF-group. In cases of ovarian hyperstimulation syndrome (n = 5) as well as in such of a mole pregnancy (n = 5), drastically elevated values of 9519 and 1496 U/ml respectively, have been demonstrated. The decidua is regarded as a presumable source of high antigen levels in normal pregnancy, while the peritoneum is assumed to be such as for the ovarian hyperstimulation syndrome. Concerning mole pregnancy, the antigen levels could possibly emerge from the amniotic fluid.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Biomarkers, Tumor; Chorionic Gonadotropin; Female; Fertilization in Vitro; Gamete Intrafallopian Transfer; Humans; Hydatidiform Mole; Infertility, Female; Menotropins; Pregnancy; Pregnancy Trimester, First; Pregnancy, Multiple; Prospective Studies; Radioimmunoassay; Reference Values; Uterine Neoplasms

A 34-year-old patient, gravida 7, para 0, with three consecutive spontaneous abortions followed by four recurrent molar pregnancies is described. The patient conceived only with clomiphene citrate or human gonadotropin treatment. The occurrence of molar pregnancies succeeded spontaneous abortions with one remaining pregnancy progressing to gestational trophoblastic disease. The role of clomiphene citrate and human gonadotropins in the pathogenesis of this disease is discussed.

Topics: Adult; Chorionic Gonadotropin; Clomiphene; Female; Humans; Hydatidiform Mole; Menotropins; Ovulation Induction; Pregnancy; Recurrence; Uterine Neoplasms

A patient who had undergone therapy with human menopausal gonadotropin had a coexistent complete hydatidiform mole and fetus. This report is the first published account of such a case.

Topics: Adult; Female; Humans; Hydatidiform Mole; Menotropins; Pregnancy; Uterine Neoplasms

The recovery of the ovarian response to gonadotropin stimulation after molar abortion was investigated in relation to the serum human chorionic gonadotropin (hCG) level. Thirteen women with an aborted mole were given 225 IU of human menopausal gonadotropin (hMG) per day for 3 consecutive days, and their serum levels of estradiol (E2) were determined by radioimmunoassay on days 1, 3, 5, and 7 after hMG administration. Women with serum hCG levels of less than 200 mIU/ml exhibited a normal increase in serum E2 levels in response to hMG, whereas women with serum hCG levels of 2000 mIU/ml or more did not show any change after hMG administration. These findings suggest that a serum level of hCG in excess of 2000 mIU/ml prevents normal ovarian E2 responsiveness to exogenous gonadotropin stimulation.

Topics: Abortion, Spontaneous; Adult; Chorionic Gonadotropin; Estradiol; Female; Humans; Hydatidiform Mole; Menotropins; Ovary; Pregnancy; Uterine Neoplasms