menotropins and Dwarfism--Pituitary

A 17-year-old male diagnosed as having Cat Eye Syndrome (CES) with hypogonadotropic hypogonadism showed short stature and no development of secondary sex characteristics. Exogeneous gonadotropin replacement therapy combining human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) was started. As a result, the short stature and androgen deficiency were relieved. The critical region of CES was tetrasomy of 22 pter-->q11. Abnormalities of other chromosomes which cause hypogonadotropic hypogonadism may exist, thus further investigation is needed.

Topics: Abnormalities, Multiple; Adolescent; Anus, Imperforate; Chorionic Gonadotropin; Chromosomes, Human, Pair 22; Dwarfism, Pituitary; Humans; Hypogonadism; Hypopituitarism; Male; Menotropins; Pituitary Hormones; Puberty, Delayed; Syndrome; Testosterone; Trisomy

The effects of hCG-hMG treatment in 13 boys with pituitary dwarfism associated with gonadotropin deficiency, were assessed. No patients except one showed signs of puberty at a bone age of 13 years or above. The one patient with some signs of puberty did not become fully mature. The hCG-hMG was started at a mean age of 20.4 years. The hCG at a dose of 5,000 IU was injected intramuscularly twice a week and the hMG at a dose of 75 IU was given once a week at first. During treatment, the frequency of hMG injections was increased to twice a week in six patients who still had not produced normal sperm counts. After a mean duration of 19.23 months, spermatozoa appeared in eight patients, of whom four showed more than 20 x 10(6) sperm/ml. Among six patients who did not have normal sperm counts and had increased hMG injections, one produced a pregnancy and four achieved sperm counts of more than 35 x 10(6)/ml. One patient had refractory azoospermia. In 13 boys with growth hormone and gonadotropin deficiency, hCG-hMG treatment produced normal spermatogenesis in nine patients, one of whom fathered a girl. Thus, hCG-hMG treatment, especially twice-a-week injections of both hCG and hMG, appears to be effective for gonadotropin deficiency in males.

Topics: Adolescent; Adult; Chorionic Gonadotropin; Drug Combinations; Dwarfism, Pituitary; Gonadotropins; Humans; Leydig Cells; Male; Menotropins; Puberty; Radioimmunoassay; Sperm Count; Spermatogenesis

Females with pituitary dwarfism of the multiple pituitary hormone deficiency form have ovarian failure due to hypogonadotropism which would be expected to respond favorably to human gonadotropin treatment. This is a description of a pituitary dwarf in whom pregnancy was achieved with gonadotropin therapy; its progress was followed regularly by hormone assays.

Topics: Adult; Body Temperature; Chorionic Gonadotropin; Dwarfism, Pituitary; Estriol; Female; Humans; Menotropins; Ovulation Induction; Placental Lactogen; Pregnancy; Progesterone; Prolactin