menotropins and Diseases-in-Twins

Paternal dispermy can be the pathogenesis of complete molar pregnancy.. A 23-year-old, white woman, gravida 4, para 1, was pregnant with a twin gestation by ovulation induction with metrodin. Ultrasound evaluation confirmed an intrauterine pregnancy in conjunction with what appeared to be a hydatidiform mole. The karyotype in the molar pregnancy, obtained from chorionic villus sampling, showed a pair of paternally derived inverted chromosomes 9, confirming the diagnosis of a complete mole. Uncontrollable hemorrhage with a rapid rise in the beta-human chorionic gonadotropin titer necessitated evacuation of the uterus. The patient was followed with beta-human chorionic gonadotropin titers for a year, with no evidence of recurrence.. This case illustrates paternal disomy in a complete molar pregnancy documented by a paternal chromosome 9 inversion.

Topics: Adult; Chorionic Gonadotropin, beta Subunit, Human; Chromosome Inversion; Chromosomes, Human, Pair 9; Diseases in Twins; Fathers; Female; Humans; Hydatidiform Mole; Menotropins; Ovulation Induction; Pregnancy; Prenatal Diagnosis; Twins

To determine incidence of hypospadias in infants born as a result of assisted reproductive technology (ART).. Prospective data collection.. Parents with various forms of infertility attended an in-hospital in vitro fertilization program.. Two of the 53 male infants, conceived as a result of ART over a 3-year period, were born with hypospadias.. Patient no. 1 underwent follicular stimulation (17 ampules of human menopausal gonadotropin (hMG), followed by 10,000 IU of human chorionic gonadotropin (hCG) 60 hours after the last hMG). Patient no. 2 underwent follicular stimulation with clomiphene citrate 100 mg/d from days 3 to 7, followed by 14 ampules of hMG starting day 6, and 10,000 IU of hCG 30 hours after her last hMG.. All infants were examined in the immediate postpartum period for congenital anomalies.. Infant no. 1, one of a set of dizygotic twins, had penoscrotal hypospadias, with normal renal sonogram and chromosomal studies. Infant no. 2 had glandular hypospadias with the urinary meatus displaced to the border of the glans.. This high incidence raises concern about possible links between assisted reproduction and hypospadias.

Topics: Adult; Chorionic Gonadotropin; Clomiphene; Diseases in Twins; Female; Fertilization in Vitro; Gamete Intrafallopian Transfer; Humans; Hypospadias; Incidence; Infant, Newborn; Menotropins