menotropins and Chemical-and-Drug-Induced-Liver-Injury

A 26-year-old married woman was admitted to our hospital because of massive ascites and hepatic injury. The patient had been treated with human menopausal gonadotropin and clomiphene citrate to prevent recurrence of spontaneous abortions. About 1 month later, she developed upper abdominal pain and noticed dark urine. On admission, she had elevated concentrations of serum transaminases with an asparate aminotransferase of 127 IU/L and alanine aminotransferase of 194 IU/L. An abdominal ultrasound showed massive ascites. Her serum concentration of estradiol was high at 12,100 pg/mL, which was much greater than the value of early stage of pregnancy (2,279-7,353 pg/mL). She was thus diagnosed as having ovarian hyperstimulation syndrome. Following a period of bed rest, her liver function normalized and the ascites disappeared. Based on the above findings, the patient was considered to have suffered from ovarian hyperstimulation syndrome, complicated by hepatic injury.

Topics: Abortion, Spontaneous; Adult; Bed Rest; Capillary Permeability; Chemical and Drug Induced Liver Injury; Clomiphene; Female; Fertility Agents, Female; Humans; Liver; Liver Diseases; Menotropins; Ovarian Hyperstimulation Syndrome; Pregnancy; Pregnancy Trimester, First

Ovarian hyperstimulation syndrome (OHS) is one of the potential complications associated with the use of human menopausal gonadotropin therapy. We recently dealt with a case of severe OHS presenting features of liver dysfunction; such a case has not been reported on before.

Topics: Adult; Chemical and Drug Induced Liver Injury; Cytoplasm; Female; Humans; Infertility, Female; Liver Diseases; Menotropins; Mitochondria, Liver; Ovary; Ovulation Induction