menotropins and Birth-Weight

To investigate neonatal outcomes and congenital malformations in children born after in vitro fertilization (IVF) and vitrified embryo transfer cycles using human menopausal gonadotrophin and medroxyprogesterone acetate (hMG + MPA) treatment.. We performed a retrospective cohort study including 4596 live born babies. During January 2014-June 2016, children born after either hMG + MPA treatment, gonadotropin releasing hormone agonist short protocol, or mild ovarian stimulation were included. The main outcome measures were neonatal outcomes and congenital malformations.. Neonatal outcomes both for singletons and twins such as mean birth weight and length, gestational age, the frequency of preterm birth were comparable between groups. Rate of stillbirth and perinatal death were also similar. No significant differences were found in the overall incidence of congenital malformations between the three groups. Multivariable logistic regression indicated that hMG + MPA regimen did not significantly increase the risk of congenital malformations compared with short protocol and mild ovarian stimulation, with adjusted odds ratio of 1.22 [95% confidence interval (CI) 0.61-2.44] and 1.38 (CI 0.65-2.93), respectively, after adjusting for confounding factors.. Our data suggested that compared with conventional ovarian stimulations, hMG + MPA treatment neither compromised neonatal outcomes of IVF newborns, nor did increase the prevalence of congenital malformations.

Topics: Birth Weight; Child; Congenital Abnormalities; Embryo Transfer; Female; Fertilization in Vitro; Gestational Age; Humans; Infant, Newborn; Live Birth; Medroxyprogesterone Acetate; Menopause; Menotropins; Ovulation Induction; Parturition; Perinatal Mortality; Pregnancy; Pregnancy Outcome; Retrospective Studies; Twins; Vitrification

To determine whether the incidence and severity of retinopathy of prematurity (ROP) differs between infants conceived naturally and those born after assisted conception, and to analyze the impact of singleton versus multiple gestation on ROP.. Comparative case series.. The study group consisted of 363 infants with a birth weight (BW) of < or =1500 g who were hospitalized in the neonatal unit of a single tertiary-care center between 1998 and 2000.. Data on gestational age (GA), BW, type of pregnancy (singleton/multiple), and type of conception (natural/assisted) were recorded, in addition to the ophthalmological results. Ophthalmological examinations were performed routinely at 4 weeks and repeated later, depending on the severity of the findings.. Presence and stage of ROP were compared between infants conceived naturally and those conceived by assisted technology, and between singleton and multiple-birth infants.. Mean GA at birth was 29.4 weeks (standard deviation, 2.5; range, 23-36). Two hundred four neonates (56.2%) were conceived naturally and 159 were conceived by assisted conception, either in vitro fertilization (IVF) alone (n = 119 [32.85%]) or IVF combined with drug treatment (n = 40 [11%]). Sixty-four infants in the natural conception group were the product of multiple pregnancies, as were 103 infants in the assisted conception group. Retinopathy of prematurity was noted in 159 of 363 infants (43.8%): 89 conceived naturally (71% singletons, 28% twins, and 17% triplets) and 70 born by assisted conception (70% singletons, 47% twins, and 33% triplets). There was no significant difference in either occurrence or severity of ROP between the natural conception and assisted conception groups. Singletons had a significantly higher rate of advanced ROP (stages II-III) (30.2%) than twins (23.1%), triplets, and quadruplets (10.6%) (P = 0.024). On multiple regression analysis, low GA and BW were the variables most significantly associated with ROP.. In our sample, assisted conception per se did not appear to be a risk factor for ROP. Singleton babies with a birth weight of < or =1500 g were more prone to develop ROP stages II and III than twins or triplets. Gestational age and BW were the most significant factors associated with ROP.

Topics: Birth Weight; Female; Fertility Agents, Female; Fertilization; Fertilization in Vitro; Gestational Age; Humans; Incidence; Infant, Newborn; Infant, Very Low Birth Weight; Israel; Menotropins; Multiple Birth Offspring; Pregnancy; Pregnancy, Multiple; Retinopathy of Prematurity; Risk Factors

During a retrospective study on 152 singles pregnancies obtained by in vitro fecondation at Tenon hospital, and followed in this department between January 1990 and December 1994, we have studied the influence of the IVF (tubal origin, masculine or idiopathic) and the type of stimulation (human menopausal gonadotrophin: hMG or follicle stimulating hormone: FSH) on the weight of the newborn and the pathologies that occurred during the pregnancy. No difference in the antecedents has been found in the different group of patients. This study shows a significative difference (p < 0.001) of the newborn's weight when the indication of IVF is tubal origin or masculine. Also, in all IVF indications, the weight is significantly (p < 0.01) higher after a follicular stimulation by FSH versus hMG. For the pregnancy pathologies, no significative difference has been noted, although arterial hypertension, fetal growth retardation and gestational diabetes appear to be more frequent in the group of women who had stimulation by hMG.

Topics: Adult; Birth Weight; Clinical Protocols; Female; Fertility Agents, Female; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Infertility; Menotropins; Ovulation Induction; Pregnancy; Pregnancy Outcome; Retrospective Studies

In this study, the effect of superovulation on the circulating levels of insulin-like growth factor binding protein-1 (IGFBP-1) has been investigated. IGFBP-1 levels were measured in singleton pregnancies achieved either naturally (n = 203) or following superovulation, in-vitro fertilisation and embryo transfer (IVF-ET) with either pituitary desensitisation with buserelin and superovulation with human menopausal gonadotrophin (b/hMG) followed by IVF-ET (n = 15) or with clomiphene citrate and hMG (CC/hMG) followed by IVF-ET (n = 15, 1st trimester only). The circulating levels of IGFBP-1 were similar in all three groups during the first trimester, and in both normal and b/hMG pregnancies in the second, but were significantly higher during the third trimester in b/hMG pregnancies than in normal pregnancies (P = 0.0002). The birth weights were significantly lower in the b/hMG group (P = 0.04), but not in the CC/hMG group compared with natural conceptions. Gestational age at delivery was similar in control and b/hMG pregnancies, but significantly reduced in CC/hMG pregnancies (P = 0.04). These data suggest that pregnancies achieved following superovulation with b/hMG are associated with elevated levels of IGFBP-1 during the third trimester of pregnancy and reduced birth weight.

Topics: Adult; Birth Weight; Carrier Proteins; Clomiphene; Endometrium; Female; Fertilization in Vitro; Humans; Insulin-Like Growth Factor Binding Protein 1; Menotropins; Pregnancy; Pregnancy Trimester, Third; Superovulation

To compare the effect of fertility drugs and IVF on the outcome of triplet pregnancies.. Prospective clinical study.. A single university medical center.. One hundred six consecutive triplet pregnancies treated from 1984 through 1992.. The frequency of pregnancy loss, livebirths, and antenatal and neonatal complications was compared in spontaneous, clomiphene citrate (CC), menotropins, and IVF triplet pregnancies.. Eighty-one of the 106 (76.4%) triplet pregnancies progressed beyond 25 weeks, comprising 6 of 7 (85.7%) spontaneous pregnancies, 13 of 16 (81.2%) CC induced, 44 of 56 (78.6%) menotropin induced, and 18 of 27 (66.6%) IVF gestations. There were no significant differences in the stillbirth and neonatal mortality rates according to the mode of conception. The mean gestational ages and the mean birth weights were similar in the four groups. The frequency of premature contractions, premature rupture of membranes, cesarean section, and neonatal complications were similar in the ovulation induction and IVF pregnancies.. Triplet pregnancies after ovulation induction and IVF have a similar outcome.

Topics: Adult; Birth Weight; Clomiphene; Embryo Transfer; Female; Fertilization in Vitro; Fetal Death; Gestational Age; Humans; Menotropins; Ovulation Induction; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Triplets

Topics: Amenorrhea; Birth Weight; Cesarean Section; Chorionic Gonadotropin; Female; Gestational Age; Humans; Infant Care; Infant, Newborn; Infertility, Female; Male; Menotropins; Organ Size; Placenta; Pregnancy; Pregnancy, Multiple; Prenatal Care