menotropins and Abortion--Threatened

The course of 60 pregnancies induced by ovulation stimulation with pergonal (in 46 cases) and lutrelef, an LHRF agonist (in 10 cases) was followed up. The authors emphasize the importance of the first therapeutic course as a preparative one, because pregnancies occurred in only 15 and 20% of patients treated with the two drugs, respectively, after it, and 25% of them failed to develop. The major pregnancy complications were due to multiple fetuses (23.4 and 20%, respectively). Stimulated pregnancy should be regarded as a high risk one in respect of spontaneous abortions; indications for abdominal delivery should be extended in such cases.

Topics: Abortion, Threatened; Adult; Amenorrhea; Female; Gonadotropin-Releasing Hormone; Humans; Infant, Newborn; Male; Menotropins; Obstetric Labor, Premature; Ovulation Induction; Pregnancy; Pregnancy Outcome; Pregnancy, Multiple