menatetrenone and Carcinoma

The pregnane X receptor (PXR) is the key regulator of our defense mechanism against foreign substances such as drugs, dietary nutrients, or environmental pollutants. Because of increased health consciousness, the use of dietary supplements has gradually increased, and most of them can activate PXR. Therefore, an analysis of the interaction between drugs and nutrients is important because altered levels of drug-metabolizing enzymes or transporters can remarkably affect the efficiency of a co-administered drug. In the present study, we analyzed the effect of vitamin K-mediated PXR activation on drug metabolism-related gene expression in intestine-derived LS180 cells via gene expression studies and western blotting analyses. We demonstrated that menaquinone 4 (MK-4), along with other vitamin Ks, including vitamin K

Topics: ATP Binding Cassette Transporter, Subfamily B; Carcinoma; Cell Line, Tumor; Cytochrome P-450 CYP3A; Gene Expression; Humans; Intestinal Neoplasms; Nutritional Physiological Phenomena; Pregnane X Receptor; Rifampin; Vitamin K; Vitamin K 1; Vitamin K 2