menaquinone-6 and Cerebral-Palsy

Due to the potentially crucial role of vitamin K. Using public libraries including PubMed and Wiley, we searched for existing research on the metabolism and use of vitamin K. Data indicated that vitamin K. Due to the existence of confounding variables and limitations in the quality and volume of research conducted, further investigation must be done to see whether the beneficial effects seen are reproducible and must assess the viability of vitamin K

Topics: Calcium; Calcium Metabolism Disorders; Cerebral Palsy; Gastrointestinal Diseases; Heart Diseases; Humans; Parathyroid Diseases; Vitamin K 2; Vitamins

Osteoporosis can lead to spontaneous fractures in adults with cerebral palsy (CP). Undercarboxylated osteocalcin (ucOC) is a useful marker for vitamin K insufficiency in osteoporosis. The primary objective of this study was to determine the effect of vitamin K2 on bone mineral density (BMD) in adults with CP and vitamin K insufficiency.. Sixteen adults, median age of 56years, with CP and osteoporosis in whom the serum ucOC concentration exceeded 4.5ng/mL were included. All patients received 45mg of vitamin K2 per day. BMD was measured and presented as a percentage of the young adult mean (%YAM). Serum levels of ucOC and BMD were measured at baseline and after 6 and 12months.. Serum levels of ucOC decreased from 7.8ng/mL (range, 4.9-32) at baseline to 3.9ng/mL (range, 1.9-6.8) after 6months (P=0.001). BMD increased from 59%YAM (range, 45-67) at baseline to 68%YAM (range, 50-79) after 12months (P=0.003).. Vitamin K2 had a positive effect on BMD in osteoporotic adults with CP and high serum concentrations of ucOC, and might be useful as a first line treatment for osteoporotic adults with CP and vitamin K insufficiency.

Topics: Adult; Bone Density; Cerebral Palsy; Female; Humans; Male; Middle Aged; Osteocalcin; Osteoporosis; Vitamin K 2