memantine has been researched along with Phantom Limb in 8 studies
Phantom Limb: Perception of painful and nonpainful phantom sensations that occur following the complete or partial loss of a limb. The majority of individuals with an amputated extremity will experience the impression that the limb is still present, and in many cases, painful. (From Neurol Clin 1998 Nov;16(4):919-36; Brain 1998 Sep;121(Pt 9):1603-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study we investigated the effect of the N-methyl-D-aspartic acid (NMDA) receptor antagonist memantine (30 mg/d) on the intensity of chronic phantom limb pain (PLP) and cortical reorganization." | 9.11 | A placebo-controlled randomized crossover trial of the N-methyl-D-aspartic acid receptor antagonist, memantine, in patients with chronic phantom limb pain. ( Birbaumer, N; Braun, C; Flor, H; Kiefer, RT; Preissl, H; Töpfner, S; Unertl, K; Wiech, K, 2004) |
| " The administration of a higher dosage is probably not tolerable." | 6.71 | Efficacy of the NMDA-receptor antagonist memantine in patients with chronic phantom limb pain--results of a randomized double-blinded, placebo-controlled trial. ( Dertwinkel, R; Hosbach, I; Maier, C; Mansourian, N; Schwenkreis, P; Senne, I; Skipka, G; Tegenthoff, M; Zenz, M, 2003) |
| "Memantine is a N-Methyl-d-aspartate receptor antagonist that has shown benefit in pain syndromes." | 6.53 | Memantine for the Treatment of Phantom Limb Pain: A Systematic Review. ( Britt, RB; Brown, JN; Loy, BM, 2016) |
| "We conclude that memantine can reduce intensity of phantom limb pain and might also prevent the development of PLP." | 5.12 | Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees. ( Birbaumer, N; Konrad, CJ; Schaller, HE; Schley, M; Schmelz, M; Topfner, S; Wiech, K, 2007) |
| "In the present study we investigated the effect of the N-methyl-D-aspartic acid (NMDA) receptor antagonist memantine (30 mg/d) on the intensity of chronic phantom limb pain (PLP) and cortical reorganization." | 5.11 | A placebo-controlled randomized crossover trial of the N-methyl-D-aspartic acid receptor antagonist, memantine, in patients with chronic phantom limb pain. ( Birbaumer, N; Braun, C; Flor, H; Kiefer, RT; Preissl, H; Töpfner, S; Unertl, K; Wiech, K, 2004) |
| " The administration of a higher dosage is probably not tolerable." | 2.71 | Efficacy of the NMDA-receptor antagonist memantine in patients with chronic phantom limb pain--results of a randomized double-blinded, placebo-controlled trial. ( Dertwinkel, R; Hosbach, I; Maier, C; Mansourian, N; Schwenkreis, P; Senne, I; Skipka, G; Tegenthoff, M; Zenz, M, 2003) |
| "Simultaneously, phantom pain intensity was assessed." | 2.71 | NMDA-mediated mechanisms in cortical excitability changes after limb amputation. ( Dertwinkel, R; Maier, C; Malin, JP; Mansourian, N; Pleger, B; Schwenkreis, P; Tegenthoff, M; Zenz, M, 2003) |
| "Memantine is a N-Methyl-d-aspartate receptor antagonist that has shown benefit in pain syndromes." | 2.53 | Memantine for the Treatment of Phantom Limb Pain: A Systematic Review. ( Britt, RB; Brown, JN; Loy, BM, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loy, BM | 1 |
| Britt, RB | 1 |
| Brown, JN | 1 |
| Buvanendran, A | 1 |
| Kroin, JS | 1 |
| Hackworth, RJ | 1 |
| Tokarz, KA | 1 |
| Fowler, IM | 1 |
| Wallace, SC | 1 |
| Stedje-Larsen, ET | 1 |
| Maier, C | 2 |
| Dertwinkel, R | 2 |
| Mansourian, N | 2 |
| Hosbach, I | 1 |
| Schwenkreis, P | 2 |
| Senne, I | 1 |
| Skipka, G | 1 |
| Zenz, M | 2 |
| Tegenthoff, M | 2 |
| Flor, H | 2 |
| Pleger, B | 1 |
| Malin, JP | 1 |
| Wiech, K | 2 |
| Kiefer, RT | 1 |
| Töpfner, S | 2 |
| Preissl, H | 1 |
| Braun, C | 1 |
| Unertl, K | 1 |
| Birbaumer, N | 2 |
| Schley, M | 1 |
| Schaller, HE | 1 |
| Konrad, CJ | 1 |
| Schmelz, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Memantine in the Treatment of Fibromyalgia: a Double-blind Randomized Trial[NCT01653457] | Phase 3 | 60 participants (Anticipated) | Interventional | 2012-09-30 | Not yet recruiting | ||
| Randomized Controlled Trial of Exercise Therapy in Combination With Central Nervous System-targeted Treatment Compared With Exercise Therapy Alone for Treatment of People With Knee Osteoarthritis[NCT03681613] | 104 participants (Anticipated) | Interventional | 2019-01-07 | Recruiting | |||
| Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients Victims of Landmines With Phantom Limb Pain[NCT01872481] | Phase 3 | 54 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for memantine and Phantom Limb
| Article | Year |
|---|---|
Memantine for the Treatment of Phantom Limb Pain: A Systematic Review.
Topics: Acute Disease; Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Memantine; Phantom Limb | 2016 |
Cortical reorganisation and chronic pain: implications for rehabilitation.
Topics: Back Pain; Biofeedback, Psychology; Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Mema | 2003 |
4 trials available for memantine and Phantom Limb
| Article | Year |
|---|---|
Efficacy of the NMDA-receptor antagonist memantine in patients with chronic phantom limb pain--results of a randomized double-blinded, placebo-controlled trial.
Topics: Adult; Aged; Chronic Disease; Demography; Double-Blind Method; Excitatory Amino Acid Antagonists; Fe | 2003 |
NMDA-mediated mechanisms in cortical excitability changes after limb amputation.
Topics: Adult; Aged; Amputation, Surgical; Cerebral Cortex; Double-Blind Method; Electric Stimulation; Elect | 2003 |
A placebo-controlled randomized crossover trial of the N-methyl-D-aspartic acid receptor antagonist, memantine, in patients with chronic phantom limb pain.
Topics: Adult; Amputation, Surgical; Chronic Disease; Cross-Over Studies; Double-Blind Method; Excitatory Am | 2004 |
Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees.
Topics: Adult; Amides; Amputation, Traumatic; Anesthetics, Local; Brachial Plexus; Double-Blind Method; Drug | 2007 |
2 other studies available for memantine and Phantom Limb
| Article | Year |
|---|---|
Early use of memantine for neuropathic pain.
Topics: Humans; Memantine; Pain; Phantom Limb; Receptors, N-Methyl-D-Aspartate | 2008 |
Profound pain reduction after induction of memantine treatment in two patients with severe phantom limb pain.
Topics: Adult; Humans; Male; Memantine; Pain; Pain Measurement; Phantom Limb; Receptors, N-Methyl-D-Aspartat | 2008 |