Page last updated: 2024-10-30

memantine and Neuralgia

memantine has been researched along with Neuralgia in 13 studies

Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

Research Excerpts

ExcerptRelevanceReference
"The authors studied patients with painful diabetic neuropathy (DN) and postherpetic neuralgia (PHN) in two crossover trials: (1) efficacy trial (dextromethorphan vs."9.10Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. ( Booher, S; Gilron, I; Max, MB; Parada, S; Sang, CN, 2002)
"The authors studied patients with painful diabetic neuropathy (DN) and postherpetic neuralgia (PHN) in two crossover trials: (1) efficacy trial (dextromethorphan vs."5.10Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. ( Booher, S; Gilron, I; Max, MB; Parada, S; Sang, CN, 2002)
" Summary effect sizes were calculated for subgroups of studies evaluating ketamine IV in complex regional pain syndrome (CRPS), oral memantine in postherptic neuralgia and, respectively, ketamine IV, and oral memantine in postamputation pain."4.86NMDA receptor antagonists for the treatment of neuropathic pain. ( Collins, S; Dahan, A; Perez, RS; Sigtermans, MJ; Zuurmond, WW, 2010)
"Considering the high prevalence of breast cancer and of post-mastectomy neuropathic pain, a clinical trial is carried out to evaluate if memantine may prevent neuropathic pain development and maintain cognitive function and quality of life in cancer patients."2.79Prevention of post-mastectomy neuropathic pain with memantine: study protocol for a randomized controlled trial. ( Dubray, C; Joly, D; Morel, V; Pereira, B; Pickering, G; Roux, D; Villatte, C, 2014)
"Dextromethorphan and memantine have been administered to animals after spinal nerve ligation (SNL) to evaluate their antinociceptive/cognitive effects and associated molecular events, including the phosphorylation of several tyrosine (pTyr(1336), pTyr(1472)) residues in the NR2B NMDAR subunit."1.40Low doses of dextromethorphan have a beneficial effect in the treatment of neuropathic pain. ( Chalus, M; Daulhac, L; Dupuis, A; Eschalier, A; Etienne, M; Morel, V; Pickering, G; Privat, AM, 2014)
"Tactile allodynia, mechanical hyperalgesia and spatial memory were evaluated by von Frey, Randall & Selitto and Y-maze-tests respectively, and molecular events by western-blot analysis."1.39Memantine, a promising drug for the prevention of neuropathic pain in rat. ( Chalus, M; Daulhac, L; Dupuis, A; Eschalier, A; Etienne, M; Morel, V; Pickering, G; Privat, AM; Wattiez, AS, 2013)
"It is still unknown whether neuropathic pain could relate to behavioral and neurochemical alterations in the central nervous system."1.35Effect of memantine on the levels of neuropeptides and microglial cells in the brain regions of rats with neuropathic pain. ( Chikuma, T; Kato, T; Muramatsu, M; Takeda, K, 2009)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's4 (30.77)29.6817
2010's7 (53.85)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Martin, E2
Sorel, M2
Morel, V6
Marcaillou, F2
Picard, P2
Delage, N2
Tiberghien, F2
Crosmary, MC1
Najjar, M1
Colamarino, R1
Créach, C1
Lietar, B1
Brumauld de Montgazon, G1
Margot-Duclot, A1
Loriot, MA1
Narjoz, C1
Lambert, C1
Pereira, B3
Pickering, G6
Capuco, A1
Urits, I1
Orhurhu, V1
Chun, R1
Shukla, B1
Burke, M1
Kaye, RJ1
Garcia, AJ1
Kaye, AD1
Viswanath, O1
Etienne, M2
Wattiez, AS1
Dupuis, A2
Privat, AM2
Chalus, M2
Eschalier, A2
Daulhac, L2
de Montgazon, G1
Roux, D2
Dubray, C2
Joly, D1
Villatte, C1
Takeda, K1
Muramatsu, M1
Chikuma, T1
Kato, T1
Collins, S1
Sigtermans, MJ1
Dahan, A1
Zuurmond, WW1
Perez, RS1
Block, F1
Habermeyer, B1
Pud, D1
Eisenberg, E2
Kleiser, A1
Dortort, A1
Haim, T1
Yarnitsky, D1
Sang, CN1
Booher, S1
Gilron, I1
Parada, S1
Max, MB1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Efficacy of Perioperative Administration of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. A Double-Blinded Randomized Controlled Trial.[NCT05935059]90 participants (Anticipated)Interventional2023-06-21Recruiting
Effect of Ultrasound Guided Erector Spinae Plane Block Versus Ultrasound Guided Serratus Anterior Block on the Incidence of Post Mastectomy Pain Syndrome, Randomized Double Blinded Controlled Study[NCT05201963]120 participants (Anticipated)Interventional2021-11-01Recruiting
Antagonists NMDA in Relay to Ketamine in Neuropathic Pain[NCT01602185]Phase 27 participants (Actual)Interventional2012-05-31Completed
Preventing the Development of Neuropathic Pain Post-mastectomy/Tumorectomy by Pre-emptive or Post-operative Memantine Administration[NCT01536314]Phase 343 participants (Actual)Interventional2012-02-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for memantine and Neuralgia

ArticleYear
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
    Current pain and headache reports, 2020, Jun-11, Volume: 24, Issue:8

    Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres

2020
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
    Current pain and headache reports, 2020, Jun-11, Volume: 24, Issue:8

    Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres

2020
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
    Current pain and headache reports, 2020, Jun-11, Volume: 24, Issue:8

    Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres

2020
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
    Current pain and headache reports, 2020, Jun-11, Volume: 24, Issue:8

    Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres

2020
Memantine for the treatment of general neuropathic pain: a narrative review.
    Fundamental & clinical pharmacology, 2018, Volume: 32, Issue:1

    Topics: Analgesics; Animals; Excitatory Amino Acid Antagonists; Humans; Memantine; Neuralgia; Pain Measureme

2018
NMDA receptor antagonists for the treatment of neuropathic pain.
    Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:11

    Topics: Excitatory Amino Acid Antagonists; Humans; Ketamine; Memantine; Neuralgia; Randomized Controlled Tri

2010
[Glutamate antagonists for treatment of neuropathic pain].
    Schmerz (Berlin, Germany), 2003, Volume: 17, Issue:4

    Topics: Amantadine; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Humans; Ketamine; Me

2003
[NMDA receptor antagonists: a new treatment for neuropathic pain].
    Harefuah, 1999, Apr-02, Volume: 136, Issue:7

    Topics: Animals; Clinical Trials as Topic; Dextromethorphan; Disease Models, Animal; Excitatory Amino Acid A

1999

Trials

4 trials available for memantine and Neuralgia

ArticleYear
Dextromethorphan and memantine after ketamine analgesia: a randomized control trial.
    Drug design, development and therapy, 2019, Volume: 13

    Topics: Administration, Oral; Adult; Aged; Analgesia; Dextromethorphan; Female; Humans; Infusions, Intraveno

2019
Rationale and design of a multicenter randomized clinical trial with memantine and dextromethorphan in ketamine-responder patients.
    Contemporary clinical trials, 2014, Volume: 38, Issue:2

    Topics: Depression; Dextromethorphan; Dose-Response Relationship, Drug; Humans; Ketamine; Memantine; Neuralg

2014
Prevention of post-mastectomy neuropathic pain with memantine: study protocol for a randomized controlled trial.
    Trials, 2014, Aug-20, Volume: 15

    Topics: Breast Neoplasms; Clinical Protocols; Cognition Disorders; Excitatory Amino Acid Antagonists; Female

2014
Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials.
    Anesthesiology, 2002, Volume: 96, Issue:5

    Topics: Adult; Aged; Dextromethorphan; Diabetic Neuropathies; Dose-Response Relationship, Drug; Double-Blind

2002

Other Studies

4 other studies available for memantine and Neuralgia

ArticleYear
Memantine, a promising drug for the prevention of neuropathic pain in rat.
    European journal of pharmacology, 2013, Dec-05, Volume: 721, Issue:1-3

    Topics: Animals; Brain; Cognition; Hyperalgesia; Ligation; Male; Memantine; Neuralgia; Phosphorylation; Rats

2013
Low doses of dextromethorphan have a beneficial effect in the treatment of neuropathic pain.
    Fundamental & clinical pharmacology, 2014, Volume: 28, Issue:6

    Topics: Animals; Cognition; Dextromethorphan; Disease Models, Animal; Dose-Response Relationship, Drug; Exci

2014
Effect of memantine on the levels of neuropeptides and microglial cells in the brain regions of rats with neuropathic pain.
    Journal of molecular neuroscience : MN, 2009, Volume: 39, Issue:3

    Topics: Analgesics; Animals; Brain; CD11 Antigens; Disease Models, Animal; Excitatory Amino Acid Antagonists

2009
Re: Headley, PM "NMDA antagonists: unequal to the task or unequal to each other--or both?".
    European journal of pain (London, England), 2000, Volume: 4, Issue:2

    Topics: Excitatory Amino Acid Antagonists; Herpes Zoster; Humans; Memantine; Neuralgia; Receptors, N-Methyl-

2000