memantine and Long Sleeper Syndrome
memantine has been researched along with Long Sleeper Syndrome in 6 studies
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Memantine was well tolerated in PD; however, specific measures of sleepiness, fatigue, depression, and attention did not significantly improve." | 5.15 | Memantine for non-motor features of Parkinson's disease: a double-blind placebo controlled exploratory pilot trial. ( Davidson, A; Lai, D; Ondo, WG; Shinawi, L, 2011) |
"Whilst dementia has long been synonymous with AD, it is becoming more widely accepted as part of the clinical spectrum in PD (PDD)." | 2.53 | Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia. ( Lewis, SJ; Szeto, JY, 2016) |
"Although Parkinson's disease (PD) has been considered to primarily affect motor abilities, increasing emphasis is being placed on cognitive and behavioural impairment in this disorder." | 2.44 | Cognitive and behavioural impairment in Parkinson's disease. ( Freedman, M; Merims, D, 2008) |
" Three head-to-head trials of ChEIs in the treatment of AD have been published to date, but are limited due to their open-label design, rates of titration, and the drug dosage levels utilised." | 2.42 | The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease. ( Herrmann, N; Lanctôt, KL; Thompson, S, 2004) |
Research
Studies (6)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (66.67) | 29.6817 |
2010's | 2 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Szeto, JY | 1 |
Lewis, SJ | 1 |
Merims, D | 1 |
Freedman, M | 1 |
Brodaty, H | 1 |
Ishida, T | 1 |
Kamei, C | 1 |
Ondo, WG | 1 |
Shinawi, L | 1 |
Davidson, A | 1 |
Lai, D | 1 |
Thompson, S | 1 |
Lanctôt, KL | 1 |
Herrmann, N | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A 16 Week, Investigator-initiated, Single-center, Double Blind, Randomized, Placebo-controlled Trial of Namenda® (Memantine Hcl) for Non-motor Symptoms in Parkinson's Disease[NCT00646204] | Phase 4 | 40 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Analyses Will be Computed for the Categorical Dependent Variable (DV): Global Tremor Assessment by Examiner
Change from baseline to end of study in the following assessment: global tremor assessment by examiner. The maximum total score is 48 and would indicate a high prevalence of tremor. The minimum total score is 0 and would indicate no tremor. (NCT00646204)
Timeframe: Baseline and 16 weeks
Intervention | scores on a scale (Mean) | |
---|---|---|
Baseline | 16 Weeks | |
Memantine-1 | 2.8 | 2.8 |
Placebo-2 | 2.8 | 2.8 |
Unified Parkinson Disease Rating Scale (UPDRS).
Assess the overall change from baseline in ON state motor United Parkinson Disease Rating scale (UPDRS) scores as assessed in the scale. The minimum score is 0 and the maximum score 199. The maximum score of 199 means the worst possible disability from Parkinson's Disease. (NCT00646204)
Timeframe: Baseline and 16 weeks
Intervention | units on a scale (Mean) | |
---|---|---|
Before treatment | After treatment | |
Memantine-1 | 12 | 10 |
Placebo-2 | 12 | 10 |
Reviews
3 reviews available for memantine and Long Sleeper Syndrome
Article | Year |
---|---|
Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia.
Topics: Alzheimer Disease; Animals; Antiparkinson Agents; Cholinesterase Inhibitors; Cognitive Behavioral Th | 2016 |
Cognitive and behavioural impairment in Parkinson's disease.
Topics: Antiparkinson Agents; Cognition Disorders; Dementia; Disease Progression; Humans; Incidence; Lewy Bo | 2008 |
The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Basal Ganglia Diseases; Bradycardia; Central Nervous System Diseas | 2004 |
Trials
1 trial available for memantine and Long Sleeper Syndrome
Article | Year |
---|---|
Memantine for non-motor features of Parkinson's disease: a double-blind placebo controlled exploratory pilot trial.
Topics: Aged; Antiparkinson Agents; Depression; Double-Blind Method; Fatigue; Female; Humans; Male; Memantin | 2011 |
Other Studies
2 other studies available for memantine and Long Sleeper Syndrome
Article | Year |
---|---|
Three steps forward, two steps back in helping people with dementia.
Topics: Dementia; Humans; Memantine; Self-Help Devices; Sleep Wake Disorders | 2009 |
Characteristic effects of anti-dementia drugs on rat sleep patterns.
Topics: Animals; Dementia; Donepezil; Dose-Response Relationship, Drug; Electroencephalography; Electromyogr | 2009 |