Page last updated: 2024-10-30

memantine and Hypothermia

memantine has been researched along with Hypothermia in 2 studies

Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.

Research Excerpts

ExcerptRelevanceReference
" We examined the effects of six compounds (memantine, dextromethorphan, haloperidol, lamotrigine, oxcarbazepine, and topiramate) on sensitivity to acute intoxicating effects of ethanol (ataxia, hypothermia, sedation/hypnosis) in C57BL/6J mice."3.75Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress. ( Chen, YC; Holmes, A, 2009)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, YC1
Holmes, A1
Moryl, E1
Danysz, W1
Quack, G1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Intraoperative Low-dose Ketamine on Incidence of Postpartum Depression in Parturients With Prenatal Depression Undergoing Cesarean Delivery: Blind Test, Randomized, Placebo-controlled Trial[NCT03336541]Phase 464 participants (Actual)Interventional2017-11-23Completed
A Randomized Double-Blind Pilot Study of Memantine Augmentation in Antidepressant Nonresponders or Incomplete Responders[NCT00344682]Phase 431 participants (Actual)Interventional2006-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Hamilton Anxiety Rating Scale (HARS)

Each item is scored on a scale of 0 (not present) to 4 (severe), with a total score range of 0-56, where <17 indicates mild severity, 18-24 mild to moderate severity and 25-30 moderate to severe. Scores > 30 indicate severe anxiety. (NCT00344682)
Timeframe: baseline & week 8

Interventionunits on a scale (Mean)
Placebo-4.13
Memantine-5.53

Modified Quick Inventory of Depressive Symptoms Self Report Scale (QIDS-SR)

The 16 item Quick Inventory of Depressive Symptomatology (QIDS-SR16) (Rush et al. 2003) is designed to assess the severity of depressive symptoms, with higher scores representing more severe forms of depression. When complete, the QIDS are scored by summing responses to obtain a total score ranging from 0 to 27. Either appetite increase or decrease, but not both, are used to calculate the total score. Weight increase or decrease, but not both, are used to calculate the total score. Scores 0-5 indicate no severity of depression; 6-10 is mild; 11-15 is moderate; 16-20 is severe; 21-27 is very severe levels of depression. Participants were evaluated at baseline and at weeks 1, 2, 3, 4, 6 & 8. (NCT00344682)
Timeframe: baseline & week 8

Interventionunits on a scale (Mean)
Placebo-3.69
Memantine-6.47

Montgomery-Asberg Depression Rating Score (MADRS)

Higher MADRS score indicates more severe depression, and each item yields a score of 0 to 6 on 10 items. The overall score ranges from 0 to 60. Scores 0 to 6 indicate symptoms absent; 7 to 19 indicates mild depression; 30 to 34 defines moderate; 35 to 60 indicates severe depression. Changes in response rate and remission rate were assessed for secondary measures. (NCT00344682)
Timeframe: baseline and week 8

Interventionunits on a scale (Mean)
Placebo-10.75
Memantine-7.13

Montgomery-Asberg Depression Rating Score (MADRS)

Higher MADRS score indicates more severe depression, and each item yields a score of 0 to 6. The overall score ranges from 0 to 60. Scores 0 to 6 indicate symptoms absent; 7 to 19 indicates mild depression; 30 to 34 defines moderate; 35 to 60 indicates severe depression. Changes in MADRS score was a primary measure. (NCT00344682)
Timeframe: Baseline & week 8

Interventionunits on a scale (Mean)
Placebo-7.25
Memantine-7.13

Other Studies

2 other studies available for memantine and Hypothermia

ArticleYear
Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:6

    Topics: Alcoholic Intoxication; Animals; Ataxia; Carbamazepine; Central Nervous System Depressants; Consciou

2009
Potential antidepressive properties of amantadine, memantine and bifemelane.
    Pharmacology & toxicology, 1993, Volume: 72, Issue:6

    Topics: Amantadine; Analysis of Variance; Animals; Antidepressive Agents; Benzhydryl Compounds; Body Tempera

1993
Potential antidepressive properties of amantadine, memantine and bifemelane.
    Pharmacology & toxicology, 1993, Volume: 72, Issue:6

    Topics: Amantadine; Analysis of Variance; Animals; Antidepressive Agents; Benzhydryl Compounds; Body Tempera

1993
Potential antidepressive properties of amantadine, memantine and bifemelane.
    Pharmacology & toxicology, 1993, Volume: 72, Issue:6

    Topics: Amantadine; Analysis of Variance; Animals; Antidepressive Agents; Benzhydryl Compounds; Body Tempera

1993
Potential antidepressive properties of amantadine, memantine and bifemelane.
    Pharmacology & toxicology, 1993, Volume: 72, Issue:6

    Topics: Amantadine; Analysis of Variance; Animals; Antidepressive Agents; Benzhydryl Compounds; Body Tempera

1993