memantine has been researched along with Brain Injuries in 19 studies
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that intracisternal injection of amiloride, an acid-sensing ion channel blocker, dose-dependently reduced cerebral hypoxia-induced neurodegeneration, seizures, and audiogenic myoclonic jerks." | 7.79 | Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. ( Tai, KK; Truong, DD, 2013) |
| "Memantine has been proven to reduce brain injury in several types of brain insults." | 5.42 | Memantine alleviates brain injury and neurobehavioral deficits after experimental subarachnoid hemorrhage. ( Cheng, YY; Chio, CC; Huang, CY; Pan, CH; Shan, YS; Tsai, KJ; Wang, HK; Wang, LC, 2015) |
| "This comprehensive review discusses clinical studies of patients following brain injuries (traumatic, acquired, or stroke), who have been treated with amantadine or memantine." | 5.05 | Amantadine and memantine: a comprehensive review for acquired brain injury. ( Ma, HM; Zafonte, RD, 2020) |
| " We found that intracisternal injection of amiloride, an acid-sensing ion channel blocker, dose-dependently reduced cerebral hypoxia-induced neurodegeneration, seizures, and audiogenic myoclonic jerks." | 3.79 | Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. ( Tai, KK; Truong, DD, 2013) |
| "Multiple events occur in the postcardiac arrest period, including excitotoxicity, mitochondrial dysfunction, and oxidative stress and inflammation, all of which contribute to ongoing brain injury and cellular death." | 2.82 | Pharmacologic neuroprotection in ischemic brain injury after cardiac arrest. ( Brosnahan, SB; Katz, A; Lam, JQ; Papadopoulos, J; Parnia, S, 2022) |
| "Moreover, MN-08 also alleviated cerebral vasospasm in a cisterna magna single-injection model in rabbits." | 1.51 | The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models. ( Guo, B; Han, Y; Ju, J; Li, N; Li, S; Liu, Z; Luo, F; Mak, S; Sun, Y; Wang, Y; Wu, L; Yang, X; Zhang, G; Zhang, Z; Zhou, Q; Zhu, Z, 2019) |
| "Memantine has been proven to reduce brain injury in several types of brain insults." | 1.42 | Memantine alleviates brain injury and neurobehavioral deficits after experimental subarachnoid hemorrhage. ( Cheng, YY; Chio, CC; Huang, CY; Pan, CH; Shan, YS; Tsai, KJ; Wang, HK; Wang, LC, 2015) |
| "Pretreatment with memantine was somewhat effective in preventing changes to the culture synchronization but was unable to fully protect the synchronization of electrical activity between neurons that showed high levels of synchronization prior to injury." | 1.38 | Protection from glutamate-induced excitotoxicity by memantine. ( Firestein, BL; Kutzing, MK; Luo, V, 2012) |
| "S-memantine was synthesized by chemically combining a slow releasing H(2)S donor 4-(3-thioxo-3H-1,2-dithiol-4-yl)-benzoic acid (ACS48) with a NMDAR antagonist memantine." | 1.38 | A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death. ( Arai, K; Atochin, DN; Ichinose, F; Khatri, A; Kida, K; Kosugi, S; Marutani, E; Nguyen, R; Tokuda, K; Van Leyen, K, 2012) |
| "Memantine treatment significantly reduced lipid peroxidation levels in the treatment group compared with other groups (P<0." | 1.33 | The effects of memantine on lipid peroxidation following closed-head trauma in rats. ( Cobanoğlu, S; Görgülü, A; Kiriş, T; Ozsüer, H, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, HM | 1 |
| Zafonte, RD | 1 |
| Polat, İ | 1 |
| Cilaker Mıcılı, S | 1 |
| Çalışır, M | 1 |
| Bayram, E | 1 |
| Yiş, U | 1 |
| Ayanoğlu, M | 1 |
| Okur, D | 1 |
| Edem, P | 1 |
| Paketçi, C | 1 |
| Tuğyan, K | 1 |
| Yılmaz, O | 1 |
| Hız Kurul, S | 1 |
| Katz, A | 1 |
| Brosnahan, SB | 1 |
| Papadopoulos, J | 1 |
| Parnia, S | 1 |
| Lam, JQ | 1 |
| Li, T | 1 |
| Luo, Z | 1 |
| Liu, Y | 1 |
| Wang, M | 1 |
| Yu, X | 1 |
| Cao, C | 1 |
| Liao, Z | 1 |
| Ding, Y | 1 |
| Yue, S | 1 |
| Luo, F | 1 |
| Wu, L | 1 |
| Zhang, Z | 2 |
| Zhu, Z | 1 |
| Liu, Z | 1 |
| Guo, B | 1 |
| Li, N | 1 |
| Ju, J | 1 |
| Zhou, Q | 1 |
| Li, S | 1 |
| Yang, X | 1 |
| Mak, S | 1 |
| Han, Y | 1 |
| Sun, Y | 1 |
| Wang, Y | 1 |
| Zhang, G | 1 |
| Tai, KK | 1 |
| Truong, DD | 1 |
| Huang, CY | 1 |
| Wang, LC | 1 |
| Wang, HK | 1 |
| Pan, CH | 1 |
| Cheng, YY | 1 |
| Shan, YS | 1 |
| Chio, CC | 1 |
| Tsai, KJ | 1 |
| Lamprecht, MR | 1 |
| Morrison, B | 1 |
| Kelestemur, T | 1 |
| Yulug, B | 1 |
| Caglayan, AB | 1 |
| Beker, MC | 1 |
| Kilic, U | 1 |
| Caglayan, B | 1 |
| Yalcin, E | 1 |
| Gundogdu, RZ | 1 |
| Kilic, E | 1 |
| Alisky, JM | 1 |
| Kim, YW | 1 |
| Shin, JC | 1 |
| An, YS | 1 |
| Litvinenko, IV | 1 |
| Emelin, AIu | 1 |
| Vorob'ev, SV | 1 |
| Lobzin, VIu | 1 |
| Kutzing, MK | 1 |
| Luo, V | 1 |
| Firestein, BL | 1 |
| Morimoto, Y | 1 |
| Zhang, Q | 1 |
| Adachi, K | 1 |
| Marutani, E | 1 |
| Kosugi, S | 1 |
| Tokuda, K | 1 |
| Khatri, A | 1 |
| Nguyen, R | 1 |
| Atochin, DN | 1 |
| Kida, K | 1 |
| Van Leyen, K | 1 |
| Arai, K | 1 |
| Ichinose, F | 1 |
| Ozsüer, H | 1 |
| Görgülü, A | 1 |
| Kiriş, T | 1 |
| Cobanoğlu, S | 1 |
| Rohde, H | 1 |
| Ikonomidou, C | 1 |
| Stefovska, V | 1 |
| Turski, L | 1 |
| Rao, VL | 1 |
| Dogan, A | 1 |
| Todd, KG | 1 |
| Bowen, KK | 1 |
| Dempsey, RJ | 1 |
2 reviews available for memantine and Brain Injuries
| Article | Year |
|---|---|
Amantadine and memantine: a comprehensive review for acquired brain injury.
Topics: Amantadine; Brain Injuries; Humans; Memantine; Neuronal Plasticity; Off-Label Use; Recovery of Funct | 2020 |
Pharmacologic neuroprotection in ischemic brain injury after cardiac arrest.
Topics: Animals; Antioxidants; Brain Injuries; Brain Ischemia; Heart Arrest; Humans; Memantine; Neuroprotect | 2022 |
3 trials available for memantine and Brain Injuries
| Article | Year |
|---|---|
Changes in cerebral glucose metabolism in patients with posttraumatic cognitive impairment after memantine therapy: a preliminary study.
Topics: Adult; Aged; Brain; Brain Injuries; Cognition Disorders; Female; Glucose; Humans; Male; Memantine; M | 2010 |
[Clinical features of the formation and possibilities of treatment of posttraumatic cognitive disturbances].
Topics: Brain Injuries; Cognition Disorders; Excitatory Amino Acid Antagonists; Female; Humans; Magnetic Res | 2010 |
[Results of clinical trials of the antispasmodic agent memantine].
Topics: Aged; Amantadine; Brain Injuries; Cerebral Palsy; Child; Child, Preschool; Clinical Trials as Topic; | 1982 |
14 other studies available for memantine and Brain Injuries
| Article | Year |
|---|---|
Neuroprotective Effects of Lacosamide and Memantine on Hyperoxic Brain Injury in Rats.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Brain Injuries; Hyperoxia; Lacosamide; Memantine; Neuro | 2020 |
Excessive Activation of NMDA Receptors Induced Neurodevelopmental Brain Damage and Cognitive Deficits in Rats Exposed to Intrauterine Hypoxia.
Topics: Animals; Brain Injuries; Cognition; Cognition Disorders; Cognitive Dysfunction; Excitatory Amino Aci | 2018 |
The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models.
Topics: Animals; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; HEK293 Cells; Hum | 2019 |
Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Brain Injuries; Heart Arrest; Hypoxia, Brain; Male; M | 2013 |
Memantine alleviates brain injury and neurobehavioral deficits after experimental subarachnoid hemorrhage.
Topics: Animals; Brain Injuries; Excitatory Amino Acid Antagonists; Male; Memantine; Mental Disorders; Motor | 2015 |
A Combination Therapy of 17β-Estradiol and Memantine Is More Neuroprotective Than Monotherapies in an Organotypic Brain Slice Culture Model of Traumatic Brain Injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Drug Therapy, Combination; Estradiol; Estrogens; Hi | 2015 |
Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine.
Topics: Animals; Brain; Brain Infarction; Brain Injuries; DNA Fragmentation; Free Radical Scavengers; Male; | 2016 |
Minimally-responsive head injury survivors may have chronic catatonia reversed years after an accident.
Topics: Accidents; Benzodiazepines; Brain Injuries; Craniocerebral Trauma; Electroconvulsive Therapy; Fructo | 2009 |
Protection from glutamate-induced excitotoxicity by memantine.
Topics: Animals; Brain Injuries; Electrophysiological Phenomena; Excitatory Amino Acid Antagonists; Glutamic | 2012 |
Effects of memantine, an N-methyl-D-aspartate receptor antagonist, on fatigue and neuronal brain damage in a rat model of combined (physical and mental) fatigue.
Topics: Animals; Brain Injuries; Fatigue; Male; Memantine; Models, Animal; Neuroprotective Agents; Pyramidal | 2012 |
A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death.
Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Cell Line, Tumor; Cells, Cultured; Drug Design; | 2012 |
The effects of memantine on lipid peroxidation following closed-head trauma in rats.
Topics: Animals; Brain; Brain Injuries; Disease Models, Animal; Excitatory Amino Acid Antagonists; Head Inju | 2005 |
Neuronal death enhanced by N-methyl-D-aspartate antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Injuries; Cell Death; Dizoc | 2000 |
Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats.
Topics: Animals; Brain Injuries; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippoc | 2001 |