memantine has been researched along with Ataxia in 10 studies
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intramuscular injection of selective NMDA receptor antagonists memantine and arcaine 4-fold decreased the incidence of pentylenetetrazole-induced generalized tonic-clonic seizures in rats, while the incidence of clonic seizures decreased by 1." | 7.74 | Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. ( Gmiro, VE; Serdyuk, SE, 2008) |
| " We examined the effects of six compounds (memantine, dextromethorphan, haloperidol, lamotrigine, oxcarbazepine, and topiramate) on sensitivity to acute intoxicating effects of ethanol (ataxia, hypothermia, sedation/hypnosis) in C57BL/6J mice." | 3.75 | Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress. ( Chen, YC; Holmes, A, 2009) |
| "Intramuscular injection of selective NMDA receptor antagonists memantine and arcaine 4-fold decreased the incidence of pentylenetetrazole-induced generalized tonic-clonic seizures in rats, while the incidence of clonic seizures decreased by 1." | 3.74 | Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. ( Gmiro, VE; Serdyuk, SE, 2008) |
| "The fragile X associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disease associated with the repetition of CGG triplets (55-200 CGG repetitions) in the FMR1 gene." | 2.61 | [Fragile X associated tremor/ataxia syndrome: its clinical presentation, pathology, and treatment]. ( Hagerman, RJ; Martinez-Cerdeno, V; Salcedo-Arellano, MJ, 2019) |
| "Memantine was neuroprotective when administered during ethanol withdrawal." | 1.37 | Administration of memantine during ethanol withdrawal in neonatal rats: effects on long-term ethanol-induced motor incoordination and cerebellar Purkinje cell loss. ( Idrus, NM; McGough, NN; Riley, EP; Thomas, JD, 2011) |
| "NMDA-induced convulsions were effectively prevented by both mono- and dications, while only dications were effective against kainate convulsions." | 1.32 | The ability of new non-competitive glutamate receptor blockers to weaken motor disorders in animals. ( Gmiro, VE; Gorbunova, LV; Lukomskaya, NY; Rukoyatkina, NI, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salcedo-Arellano, MJ | 1 |
| Hagerman, RJ | 5 |
| Martinez-Cerdeno, V | 1 |
| Seritan, AL | 2 |
| Nguyen, DV | 2 |
| Mu, Y | 1 |
| Tassone, F | 1 |
| Bourgeois, JA | 2 |
| Schneider, A | 3 |
| Cogswell, JB | 2 |
| Cook, KR | 1 |
| Leehey, MA | 1 |
| Grigsby, J | 2 |
| Olichney, JM | 3 |
| Adams, PE | 1 |
| Legg, W | 1 |
| Zhang, L | 1 |
| Hagerman, PJ | 2 |
| Yang, JC | 2 |
| Niu, YQ | 2 |
| Simon, C | 2 |
| Chen, L | 1 |
| Moghaddam, ST | 1 |
| Rodriguez, A | 1 |
| Royston, A | 1 |
| Avar, M | 1 |
| Brill, R | 1 |
| Chen, YC | 1 |
| Holmes, A | 1 |
| Gmiro, VE | 2 |
| Serdyuk, SE | 1 |
| Ortigas, MC | 1 |
| Olichney, J | 1 |
| Hall, DA | 1 |
| Idrus, NM | 1 |
| McGough, NN | 1 |
| Riley, EP | 1 |
| Thomas, JD | 1 |
| Rukoyatkina, NI | 1 |
| Gorbunova, LV | 1 |
| Lukomskaya, NY | 1 |
| Hesselink, MB | 1 |
| Smolders, H | 1 |
| De Boer, AG | 1 |
| Breimer, DD | 1 |
| Danysz, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterization and Treatment of CNS Abnormalities in Premutation Carriers: A Double-Blind Placebo-Controlled Trial of Memantine[NCT00584948] | 94 participants (Actual) | Interventional | 2007-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The BDS-II is a 9-item, 27-point instrument that measures executive function as the capacity for behavioral and attentional self-regulation. Total score is a sum of the 9 items, with a range of 0-27, in which a higher score indicates a better performance. (NCT00584948)
Timeframe: One Year
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | One Year | |
| Memantine | 17.44 | 15.66 |
| Placebo | 16.12 | 15.72 |
The CATSYS is a set of computer assisted diagnostic instruments that can measure intention tremor, postural tremor, postural sway, manual coordination and reaction time. The tremor intensity is defined as the root mean square of accelerations, recorded in the 0.9 Hz to 15.0 Hz band during the test period. Unit is measured in m/s2 (NCT00584948)
Timeframe: 1 year
| Intervention | m/s^2 (Mean) | |
|---|---|---|
| Baseline | One Year | |
| Memantine | 1.31 | 1.77 |
| Placebo | 1.05 | 1.89 |
1 review available for memantine and Ataxia
| Article | Year |
|---|---|
[Fragile X associated tremor/ataxia syndrome: its clinical presentation, pathology, and treatment].
Topics: Antidepressive Agents; Ataxia; Brain; Deep Brain Stimulation; Female; Fragile X Mental Retardation P | 2019 |
3 trials available for memantine and Ataxia
| Article | Year |
|---|---|
Memantine for fragile X-associated tremor/ataxia syndrome: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Ataxia; Double-Blind Method; Female; Fragile X | 2014 |
Memantine effects on verbal memory in fragile X-associated tremor/ataxia syndrome (FXTAS): a double-blind brain potential study.
Topics: Ataxia; Brain; Double-Blind Method; Electroencephalography; Evoked Potentials; Excitatory Amino Acid | 2014 |
Memantine Improves Attentional Processes in Fragile X-Associated Tremor/Ataxia Syndrome: Electrophysiological Evidence from a Randomized Controlled Trial.
Topics: Aged; Ataxia; Attention; Cognitive Dysfunction; Drug Administration Schedule; Electroencephalography | 2016 |
6 other studies available for memantine and Ataxia
| Article | Year |
|---|---|
Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress.
Topics: Alcoholic Intoxication; Animals; Ataxia; Carbamazepine; Central Nervous System Depressants; Consciou | 2009 |
Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia.
Topics: Animals; Ataxia; Biguanides; Drug Synergism; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Male | 2008 |
Improving fragile X-associated tremor/ataxia syndrome symptoms with memantine and venlafaxine.
Topics: Aged; Ataxia; Cyclohexanols; Drug Therapy, Combination; Female; Follow-Up Studies; Fragile X Mental | 2010 |
Administration of memantine during ethanol withdrawal in neonatal rats: effects on long-term ethanol-induced motor incoordination and cerebellar Purkinje cell loss.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Ataxia; Cerebellum; Ethanol; Excitatory Amino Acid Anta | 2011 |
The ability of new non-competitive glutamate receptor blockers to weaken motor disorders in animals.
Topics: Animals; Ataxia; Behavior, Animal; Catalepsy; Diamines; Disease Models, Animal; Dizocilpine Maleate; | 2003 |
Modifications of the behavioral profile of non-competitive NMDA receptor antagonists, memantine, amantadine and (+)MK-801 after chronic administration.
Topics: Amantadine; Animals; Ataxia; Avoidance Learning; Behavior, Animal; Catalepsy; Dizocilpine Maleate; D | 1999 |