memantine has been researched along with Amyloid Deposits in 12 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Current approved drug treatments for Alzheimer disease (AD) include cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and the NMDA receptor antagonist memantine." | 4.88 | New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs. ( Caraci, F; Drago, F; Fedotova, J; Leggio, GM; Salomone, S, 2012) |
| "The first drugs developed for Alzheimer's disease (AD), anticholinesterase inhibitors (AchEI), increase acetylcholine levels, previously demonstrated to be reduced in AD." | 2.49 | Immunotherapy against amyloid pathology in Alzheimer's disease. ( Galimberti, D; Ghezzi, L; Scarpini, E, 2013) |
| "The cognitive symptoms of Alzheimer's disease (AD) are believed to be caused not only by the loss of neurons in the cholinergic and glutamatergic neural systems but also by the irregular functioning of surviving neurons in these 2 systems." | 2.43 | Neuropathologic changes in Alzheimer's disease: potential targets for treatment. ( Wenk, GL, 2006) |
| "Memantine followed a slower release profile from the NPs against the free drug solution, allowing to reduce drug administration frequency in vivo." | 1.48 | Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization. ( Calpena, AC; Camins, A; Cano, A; Carmona, N; Egea, MA; Espina, M; Ettcheto, M; García, ML; Sánchez-López, E; Silva, AM; Souto, EB, 2018) |
| "Memantine (MEM) has been indicated to dramatically increase hippocampal neurogenesis by promoting the proliferation of RGLs." | 1.42 | Protection of Radial Glial-Like Cells in the Hippocampus of APP/PS1 Mice: a Novel Mechanism of Memantine in the Treatment of Alzheimer's Disease. ( Bao, X; Cai, Y; Chen, J; Fan, X; Huang, J; Huang, W; Sun, D; Xu, H; Zhao, J, 2015) |
| "However, patients with Alzheimer's disease seem not only to forget events but also to express false confidence in remembering events that have never happened." | 1.38 | False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine. ( Bussey, TJ; Cho, K; Heath, CJ; McTighe, SM; Romberg, C; Saksida, LM; Whitcomb, DJ, 2012) |
| "Formation of senile plaques composed of amyloid beta peptide, a pathological hallmark of Alzheimer disease, in human brains precedes disease onset by many years." | 1.33 | 19F and 1H MRI detection of amyloid beta plaques in vivo. ( Higuchi, M; Iwata, N; Matsuba, Y; Saido, TC; Sasamoto, K; Sato, K, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ettcheto, M | 2 |
| Sánchez-López, E | 2 |
| Gómez-Mínguez, Y | 1 |
| Cabrera, H | 1 |
| Busquets, O | 1 |
| Beas-Zarate, C | 1 |
| García, ML | 2 |
| Carro, E | 1 |
| Casadesus, G | 1 |
| Auladell, C | 1 |
| Vázquez Carrera, M | 1 |
| Folch, J | 1 |
| Camins, A | 2 |
| Egea, MA | 1 |
| Espina, M | 1 |
| Cano, A | 1 |
| Calpena, AC | 1 |
| Carmona, N | 1 |
| Silva, AM | 1 |
| Souto, EB | 1 |
| Sun, D | 1 |
| Chen, J | 1 |
| Bao, X | 1 |
| Cai, Y | 1 |
| Zhao, J | 1 |
| Huang, J | 1 |
| Huang, W | 1 |
| Fan, X | 1 |
| Xu, H | 1 |
| Schmidt, R | 1 |
| Neff, F | 1 |
| Lampl, C | 1 |
| Benke, T | 1 |
| Anditsch, M | 1 |
| Bancher, C | 1 |
| Dal-Bianco, P | 1 |
| Reisecker, F | 1 |
| Marksteiner, J | 1 |
| Rainer, M | 1 |
| Kapeller, P | 1 |
| Dodel, R | 1 |
| Salomone, S | 1 |
| Caraci, F | 1 |
| Leggio, GM | 1 |
| Fedotova, J | 1 |
| Drago, F | 1 |
| Ritter, JM | 1 |
| Romberg, C | 1 |
| McTighe, SM | 1 |
| Heath, CJ | 1 |
| Whitcomb, DJ | 1 |
| Cho, K | 1 |
| Bussey, TJ | 1 |
| Saksida, LM | 1 |
| Galimberti, D | 1 |
| Ghezzi, L | 1 |
| Scarpini, E | 1 |
| Higuchi, M | 1 |
| Iwata, N | 1 |
| Matsuba, Y | 1 |
| Sato, K | 1 |
| Sasamoto, K | 1 |
| Saido, TC | 1 |
| Small, SA | 1 |
| Wenk, GL | 1 |
| Dong, H | 1 |
| Yuede, CM | 1 |
| Coughlan, C | 1 |
| Lewis, B | 1 |
| Csernansky, JG | 1 |
4 reviews available for memantine and Amyloid Deposits
| Article | Year |
|---|---|
[Therapy of Alzheimer's disease: current status and future development].
Topics: Alzheimer Disease; Alzheimer Vaccines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; | 2008 |
New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs.
Topics: Alzheimer Disease; Clinical Trials as Topic; Donepezil; Drug Discovery; Excitatory Amino Acid Antago | 2012 |
Immunotherapy against amyloid pathology in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonis | 2013 |
Neuropathologic changes in Alzheimer's disease: potential targets for treatment.
Topics: Acetylcholine; Alzheimer Disease; Calcium Channels; Cholinergic Fibers; Cognition Disorders; Excitat | 2006 |
8 other studies available for memantine and Amyloid Deposits
| Article | Year |
|---|---|
Peripheral and Central Effects of Memantine in a Mixed Preclinical Mice Model of Obesity and Familial Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Body Weight; Cognition; Diet, High-Fat; Disease M | 2018 |
Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antiparkinson Agents; Astro | 2018 |
Protection of Radial Glial-Like Cells in the Hippocampus of APP/PS1 Mice: a Novel Mechanism of Memantine in the Treatment of Alzheimer's Disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Bromodeoxyuridine; Cel | 2015 |
Drugs for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Drug Design; Excitatory Amino Acid Antagonists; Galant | 2012 |
False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Electric Stimula | 2012 |
19F and 1H MRI detection of amyloid beta plaques in vivo.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; | 2005 |
Alzheimer disease, in living color.
Topics: Alzheimer Disease; Animals; Disease Progression; Humans; Magnetic Resonance Imaging; Memantine; Mice | 2005 |
Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Axons; Behavior, Animal; Brain; Conditioning, Psychological; Disease Mod | 2008 |