Page last updated: 2024-10-30

memantine and Amnesia

memantine has been researched along with Amnesia in 7 studies

Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)

Research Excerpts

ExcerptRelevanceReference
"We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in the scopolamine-induced amnesia model in mice."7.78Synergistic effects of galantamine and memantine in attenuating scopolamine-induced amnesia in mice. ( Bertorelli, R; Busquet, P; Capurro, V; Cavalli, A; Piomelli, D; Reggiani, A, 2012)
"We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in the scopolamine-induced amnesia model in mice."3.78Synergistic effects of galantamine and memantine in attenuating scopolamine-induced amnesia in mice. ( Bertorelli, R; Busquet, P; Capurro, V; Cavalli, A; Piomelli, D; Reggiani, A, 2012)
"Current therapies in Alzheimer's disease (AD), including Memantine, have proven to be only symptomatic but not curative or disease modifying."1.62Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease. ( Bouchet, M; Couly, S; Denus, M; Maurice, T; Rubinstenn, G, 2021)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's4 (57.14)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Jaimes, LF1
Mansk, LMZ1
Almeida-Santos, AF1
Pereira, GS1
Couly, S1
Denus, M1
Bouchet, M1
Rubinstenn, G1
Maurice, T1
Ilhan Algin, D1
Dagli Atalay, S1
Ozkan, S1
Ozbabalik Adapinar, D1
Ak Sivrioz, I1
Barber, TA1
Haggarty, MK1
Peters, O1
Lorenz, D1
Fesche, A1
Schmidtke, K1
Hüll, M1
Perneczky, R1
Rüther, E1
Möller, HJ1
Jessen, F1
Maier, W1
Kornhuber, J1
Jahn, H1
Luckhaus, C1
Gertz, HJ1
Schröder, J1
Pantel, J1
Teipel, S1
Wellek, S1
Frölich, L1
Heuser, I1
Busquet, P1
Capurro, V1
Cavalli, A1
Piomelli, D1
Reggiani, A1
Bertorelli, R1
Ferris, S1
Schneider, L1
Farmer, M1
Kay, G1
Crook, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Combined Memantine (Namenda) Plus Escitalopram (Lexapro) Treatment in Elderly Depressed Patients With Cognitive Impairment[NCT01876823]Phase 2/Phase 360 participants (Actual)Interventional2006-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in 24-item HAMD

Change in 24-item Hamilton Rating Scale for Depression (HAMD) scores from baseline to Week 48: HAMD measures depression severity based on a series of 24 items items. The range of HAMD total score is 0-74; 0 indicates no depressive symptoms and a maximum HAMD score is a 74, where the greater the score indicates more significant psychopathology. In this study, moderate to severe depression is considered a HAMD-24 greater than 14. (NCT01876823)
Timeframe: Baseline, Week 48

Interventionscores on a scale (Mean)
Es-citalopram and Memantine Treatment-15.2

Change in Selective Reminding Test - Delayed Recall (SRT-DR)

Change in Selective Reminding Test-Delayed Recall scores from baseline to Week 48: SRT Delay is administered 15 minutes after the immediate recall portion. Patients are asked to remember as many of the words as they can from the 6 trials. Maximum raw score is a 12 for free recall. If a patient is unable to recall a word, they are given a chance to recognize it among three incorrect word choices. Maximum raw score for recognition is 12. The greater the score on the delayed recall portion, the better the patient does on the assessment. (NCT01876823)
Timeframe: Baseline, Week 48

Interventionunits on a scale (Mean)
Es-citalopram and Memantine Treatment1.2

Change in Selective Reminding Test - Total Immediate Recall (SRT-IR)

Change in Selective Reminding Test-Total Immediate Recall (SRT-IR) scores from baseline to Week 48: Measures word recall (maximum 12 words per trial, across 6 trials). Maximum total recall score across 6 trials is 72; minimum recall is 0 across 6 trials. The higher the raw score, the better the patient did at recalling the target words. The unit of measure is the raw score, or the sum of the number of words recalled across all 6 trials. (NCT01876823)
Timeframe: baseline, 48 weeks

Interventionunits on a scale (Mean)
Es-citalopram and Memantine Treatment7.5

Change in Trails A

Change in Trails A scores from baseline to Week 48: Measures attention and executive function. It asks patients to connect numbers from 1-25 in numerical order as fast as they can. Patients are timed; the longer it takes for the patient to connect the numbers, the worse their score. Unit of measure is in seconds. The amount of errors that the patient makes during trails is also recorded. (NCT01876823)
Timeframe: Baseline, Week 48

Interventionseconds (Mean)
Es-citalopram and Memantine Treatment1.9

Change in Trails B

Change from baseline to Week 48 on Trails B: Measures attention and executive function. It asks patients to connect numbers and letters in numerical to alphabetical order from (1-13 and A-L) as fast as they can. Patients are timed; the longer it takes for the patient to connect the numbers and letters, the worse their score. Unit of measure is in seconds. The amount of errors that the patient makes during trails is also recorded. (NCT01876823)
Timeframe: Baseline, Week 48

Interventionseconds (Mean)
Es-citalopram and Memantine Treatment-36.3

Change in Wechsler Memory Scale-III (WMS-III)

Change in Wechsler Memory Scale-III scores from baseline to Week 48: The WMS-III Visual Reproduction sub-test was used to measure visual working memory and delayed memory. Patients were shown pictures of four drawings and were asked to reproduce them from memory immediately after seeing them, and 25 minutes after seeing them. The four scores are summed and the greater the total raw score, the better the patient did on the assessment. The maximum raw score for this test is a 41 on both the immediate and delayed portions (the overall range is 0-82 points). The change score is calculated using the total scores of both the immediate and delayed portions. (NCT01876823)
Timeframe: Baseline, Week 48

Interventionunits on a scale (Mean)
Es-citalopram and Memantine Treatment9.9

Conversion to Dementia Using Clinical Dementia Rating (CDR)

The CDR is a numeric rating scale that is used to quantify the severity of one's cognitive function. The scale goes from 0=normal; 0.5=mild cognitive impairment; 1 to 3=mild to moderate/severe dementia. CDR was used a dichotomous outcome measure (no=0; yes=1). (NCT01876823)
Timeframe: Baseline, Week 48

Interventionparticipants (Number)
Es-citalopram and Memantine Treatment1

Change in Clinical Global Impression - Cognitive Change

The CGI Cognitive Change follows a seven-point likert scale. Compared to the patient's condition at baseline in the study [prior to medication initiation], the patient's condition is rated as: 1=very much improved since the initiation of treatment; 2=much improved; 3=minimally improved; 4=no change from baseline (the initiation of treatment); 5=minimally worse; 6= much worse; 7=very much worse since the initiation of treatment. Responses from the entire group were calculated. Mean at final visit and baseline is reported below. (NCT01876823)
Timeframe: Baseline, Week 48

Interventionunits on a scale (Mean)
CGI-Cognitive Change (Baseline)Clinical Global Impression-Cogntive Change (WK 48)
Es-citalopram and Memantine Treatment3.62.7

Change in Clinical Global Impression - Depression Change

The CGI Depression Change follows a seven-point likert scale. Compared to the patient's condition at baseline in the study [prior to medication initiation], the patient's condition is rated as: 1=very much improved since the initiation of treatment; 2=much improved; 3=minimally improved; 4=no change from baseline (the initiation of treatment); 5=minimally worse; 6= much worse; 7=very much worse since the initiation of treatment. Responses were calculated for the entire group. Mean at final visit has been reported below. Higher mean at baseline indicates a decrease in depression scores. (NCT01876823)
Timeframe: Baseline, Week 48

Interventionunits on a scale (Mean)
Cognitive Global Impression at BaselineCognitive Global Impression at Final Visit (WK 48)
Es-citalopram and Memantine Treatment4.12.1

Change in Treatment Emergent Side Effects (TESS)

"Somatic side effect rating scale which includes 26 common somatic side effects associated with previous medication clinical trials; rated by the study physician. Factors were dichotomized to yes or no responses on this scale, which equated to the symptom being either present or not present. Yes and no responses were given a value of 0 (no) or 1 (yes). Responses from the entire group were calculated and the mean at baseline and the last visit is reported below." (NCT01876823)
Timeframe: Baseline, Week 48

Interventionunits on a scale (Mean)
Treatment Emergent Side Effects (Baseline)Treatment Emergent Side Effects (WK 48)
Es-citalopram and Memantine Treatment6.63.2

Trials

3 trials available for memantine and Amnesia

ArticleYear
Memantine improves semantic memory in patients with amnestic mild cognitive impairment: A single-photon emission computed tomography study.
    The Journal of international medical research, 2017, Volume: 45, Issue:6

    Topics: Aged; Amnesia; Cognitive Dysfunction; Demography; Female; Humans; Male; Memantine; Memory; Middle Ag

2017
A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI.
    The journal of nutrition, health & aging, 2012, Volume: 16, Issue:6

    Topics: Aged; Alzheimer Disease; Amnesia; Cholinesterase Inhibitors; Cognition; Cognitive Dysfunction; Cohor

2012
A double-blind, placebo-controlled trial of memantine in age-associated memory impairment (memantine in AAMI).
    International journal of geriatric psychiatry, 2007, Volume: 22, Issue:5

    Topics: Age Factors; Aged; Alzheimer Disease; Amnesia; Attention; Double-Blind Method; Excitatory Amino Acid

2007

Other Studies

4 other studies available for memantine and Amnesia

ArticleYear
Maturation of newborn neurons predicts social memory persistence in mice.
    Neuropharmacology, 2020, Volume: 171

    Topics: Actins; Amnesia; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dendrites; Doublecortin Protein;

2020
Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease.
    The international journal of neuropsychopharmacology, 2021, 02-15, Volume: 24, Issue:2

    Topics: Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Behavior, Animal; Disease Models, Animal

2021
Memantine ameliorates scopolamine-induced amnesia in chicks trained on taste-avoidance learning.
    Neurobiology of learning and memory, 2010, Volume: 93, Issue:4

    Topics: Amnesia; Animals; Avoidance Learning; Chickens; Cholinergic Antagonists; Excitatory Amino Acid Antag

2010
Synergistic effects of galantamine and memantine in attenuating scopolamine-induced amnesia in mice.
    Journal of pharmacological sciences, 2012, Volume: 120, Issue:4

    Topics: Amnesia; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Galantamine; Ma

2012