Page last updated: 2024-10-30
memantine and Ache
memantine has been researched along with Ache in 31 studies
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "A combination therapy of morphine with an NMDA-receptor antagonist might be more effective than morphine without a NMDA-receptor antagonist for the relief of neuropathic pain in patients with complex regional pain syndrome (CRPS)." | 9.14 | NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation. ( Birbaumer, N; Flor, H; Gustin, SM; Larbig, W; Lotze, M; Schmidt, AC; Schwarz, A; Sines, N; Veit, R, 2010) |
| "The authors studied patients with painful diabetic neuropathy (DN) and postherpetic neuralgia (PHN) in two crossover trials: (1) efficacy trial (dextromethorphan vs." | 9.10 | Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. ( Booher, S; Gilron, I; Max, MB; Parada, S; Sang, CN, 2002) |
| "In a randomized, double-blinded and cross-over study, the analgesic effect of memantine (a drug which reduces the excitability of sensitized neurons in the dorsal horn) was examined in 19 patients with chronic pain after nerve injury." | 9.09 | Memantine (a N-methyl-D-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery: a randomized, double-blinded, cross-over study. ( Gottrup, H; Jensen, TS; Kristensen, AG; Nikolajsen, L, 2000) |
| "To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats." | 7.72 | Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats. ( Back, SK; Han, HC; Hong, SK; Kim, YI; Lee, KS; Min, SS; Na, HS; Yoon, SJ; Yoon, YW; Zhang, GH, 2004) |
| "The present study examined the effects of local peripheral and systemic administration of three clinically used excitatory amino acid receptor antagonists (dextromethorphan, memantine, ketamine) on pain behaviors and edema produced by formalin (1." | 7.71 | Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. ( Reid, A; Sawynok, J, 2002) |
| "Fibromyalgia is a prevalent chronic rheumatic disease of great clinical importance." | 6.78 | Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up. ( Andrés, E; Arcega, R; Garcia-Campayo, J; López-del-Hoyo, Y; Magallon, R; Masluk, B; Olivan-Blázquez, B; Pérez-Yus, MC; Puebla, M; Roca, M, 2013) |
| "A combination therapy of morphine with an NMDA-receptor antagonist might be more effective than morphine without a NMDA-receptor antagonist for the relief of neuropathic pain in patients with complex regional pain syndrome (CRPS)." | 5.14 | NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation. ( Birbaumer, N; Flor, H; Gustin, SM; Larbig, W; Lotze, M; Schmidt, AC; Schwarz, A; Sines, N; Veit, R, 2010) |
| "The authors studied patients with painful diabetic neuropathy (DN) and postherpetic neuralgia (PHN) in two crossover trials: (1) efficacy trial (dextromethorphan vs." | 5.10 | Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. ( Booher, S; Gilron, I; Max, MB; Parada, S; Sang, CN, 2002) |
| "In a randomized, double-blinded and cross-over study, the analgesic effect of memantine (a drug which reduces the excitability of sensitized neurons in the dorsal horn) was examined in 19 patients with chronic pain after nerve injury." | 5.09 | Memantine (a N-methyl-D-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery: a randomized, double-blinded, cross-over study. ( Gottrup, H; Jensen, TS; Kristensen, AG; Nikolajsen, L, 2000) |
| "Memantine hydrochloride, an NMDA antagonist, was launched in Germany by Merz in 1989 for the treatment of dementia, an indication for which development was continuing in other markets." | 4.81 | Memantine. Merz. ( Kilpatrick, GJ; Tilbrook, GS, 2002) |
| "We investigated the influence of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine on pain pathways involving trigeminocervical complex (TCC) using a formalin injection model." | 3.78 | Influence of memantine on nociceptive responses of the trigeminocervical complex after formalin injection. ( Park, GE; Park, JW; Shin, HE; Suh, GI, 2012) |
| " The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "A series of mutual prodrugs derived from gabapentin, pregabalin, memantine, venlafaxine were synthesized and their pharmacological properties to treat neuropathic pain were investigated in a rat model of chronic sciatic nerve constriction injury (CCI)." | 3.72 | Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury. ( Bo-Hua, Z; He, L; Hong-Ju, Y; Jun-Wei, W; Nan, Z; Wei-Guo, S; Wei-Xiu, Y; Zhe-Hui, G; Zheng-Hua, G; Zhi-Pu, L; Zhong-Wei, J, 2004) |
| "To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats." | 3.72 | Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats. ( Back, SK; Han, HC; Hong, SK; Kim, YI; Lee, KS; Min, SS; Na, HS; Yoon, SJ; Yoon, YW; Zhang, GH, 2004) |
| "The present study examined the effects of local peripheral and systemic administration of three clinically used excitatory amino acid receptor antagonists (dextromethorphan, memantine, ketamine) on pain behaviors and edema produced by formalin (1." | 3.71 | Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. ( Reid, A; Sawynok, J, 2002) |
| " Ifenprodil and some other NMDA antagonists (MK-801, memantine) were tested in a model of inflammatory pain (Randall-Selitto) in rats." | 3.71 | Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil. ( Chizh, BA; Englberger, W; Haase, G; Reissmüller, E; Scheede, M; Schlütz, H, 2001) |
| "Fibromyalgia is a prevalent chronic rheumatic disease of great clinical importance." | 2.78 | Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up. ( Andrés, E; Arcega, R; Garcia-Campayo, J; López-del-Hoyo, Y; Magallon, R; Masluk, B; Olivan-Blázquez, B; Pérez-Yus, MC; Puebla, M; Roca, M, 2013) |
| "Dementia is a risk factor for delirium, and their symptoms can be similar." | 2.72 | Chronic Brain Failure. ( Wolak, JP, 2021) |
| " It is concluded that co-administration of Vit B12 and morphine could reduce tolerance to analgesic effect of morphine chronic administration and also reduce its withdrawal symptoms." | 1.40 | Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice. ( Etemad, L; Ghazanfari, S; Hosseinzadeh, H; Imenshahidi, M; Moshiri, M, 2014) |
| "Memantine is a N-methyl-D-aspartic acid receptor (NMDAR) channel blocker that binds to dizocilpine sites and appears well tolerated during chronic use." | 1.39 | Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine. ( Chen, Y; Evola, M; Young, AM, 2013) |
| " Here we determined the antinociceptive effect of chronic administration of neramexane and compared its effect with that of memantine and gabapentin in a rat model of diabetic neuropathic pain." | 1.35 | Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. ( Chen, SR; Pan, HL; Samoriski, G, 2009) |
| " Thus, studies on the prevention and management of chronic pain should focus on preemptive or long-term administration of NMDA receptor antagonists." | 1.32 | Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain. ( Aliev, K; Belozertseva, IV; Bespalov, AY; Danysz, W; Malyshkin, AA; Medvedev, IO; Parsons, CG; Sevostianova, NY; Sukhotina, IA; Zvartau, EE, 2004) |
| " As assessed by cumulative dose-response approach in the tail-flick test, administration of 10 mg kg(-1) morphine bid s." | 1.31 | Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice. ( Kozela, E; Pilc, A; Popik, P, 2000) |
Research
Studies (31)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (9.68) | 18.2507 |
| 2000's | 20 (64.52) | 29.6817 |
| 2010's | 7 (22.58) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Williams, M | 1 |
| Kowaluk, EA | 1 |
| Arneric, SP | 1 |
| Wolak, JP | 1 |
| Ghazanfari, S | 1 |
| Imenshahidi, M | 1 |
| Etemad, L | 1 |
| Moshiri, M | 1 |
| Hosseinzadeh, H | 1 |
| Chen, YW | 2 |
| Tzeng, JI | 1 |
| Pan, HJ | 1 |
| Hung, CH | 2 |
| Chen, YC | 1 |
| Wang, JJ | 2 |
| Wu, BT | 1 |
| Chen, KT | 1 |
| Liu, KS | 1 |
| Buvanendran, A | 1 |
| Kroin, JS | 1 |
| Hackworth, RJ | 1 |
| Tokarz, KA | 1 |
| Fowler, IM | 1 |
| Wallace, SC | 1 |
| Stedje-Larsen, ET | 1 |
| Recla, JM | 1 |
| Sarantopoulos, CD | 1 |
| Chen, SR | 1 |
| Samoriski, G | 1 |
| Pan, HL | 1 |
| Gustin, SM | 1 |
| Schwarz, A | 1 |
| Birbaumer, N | 1 |
| Sines, N | 1 |
| Schmidt, AC | 1 |
| Veit, R | 1 |
| Larbig, W | 1 |
| Flor, H | 1 |
| Lotze, M | 1 |
| Park, JW | 1 |
| Suh, GI | 1 |
| Shin, HE | 1 |
| Park, GE | 1 |
| Chen, Y | 1 |
| Evola, M | 1 |
| Young, AM | 1 |
| Olivan-Blázquez, B | 1 |
| Puebla, M | 1 |
| Masluk, B | 1 |
| Pérez-Yus, MC | 1 |
| Arcega, R | 1 |
| Andrés, E | 1 |
| López-del-Hoyo, Y | 1 |
| Magallon, R | 1 |
| Roca, M | 1 |
| Garcia-Campayo, J | 1 |
| Sawynok, J | 1 |
| Reid, A | 1 |
| Berrino, L | 1 |
| Oliva, P | 1 |
| Massimo, F | 1 |
| Aurilio, C | 1 |
| Maione, S | 1 |
| Grella, A | 1 |
| Rossi, F | 1 |
| Danysz, W | 2 |
| Hong-Ju, Y | 1 |
| He, L | 1 |
| Wei-Guo, S | 1 |
| Nan, Z | 1 |
| Wei-Xiu, Y | 1 |
| Zhong-Wei, J | 1 |
| Jun-Wei, W | 1 |
| Zheng-Hua, G | 1 |
| Bo-Hua, Z | 1 |
| Zhi-Pu, L | 1 |
| Zhe-Hui, G | 1 |
| Medvedev, IO | 1 |
| Malyshkin, AA | 1 |
| Belozertseva, IV | 1 |
| Sukhotina, IA | 1 |
| Sevostianova, NY | 1 |
| Aliev, K | 1 |
| Zvartau, EE | 1 |
| Parsons, CG | 1 |
| Bespalov, AY | 1 |
| Zhang, GH | 1 |
| Min, SS | 1 |
| Lee, KS | 1 |
| Back, SK | 1 |
| Yoon, SJ | 1 |
| Yoon, YW | 1 |
| Kim, YI | 1 |
| Na, HS | 1 |
| Hong, SK | 1 |
| Han, HC | 1 |
| Nakazato, E | 1 |
| Kato, A | 1 |
| Watanabe, S | 1 |
| Gil, DW | 1 |
| Cheevers, CV | 1 |
| Donello, JE | 1 |
| Chaplan, SR | 1 |
| Malmberg, AB | 1 |
| Yaksh, TL | 1 |
| Davidson, EM | 1 |
| Carlton, SM | 1 |
| Popik, P | 1 |
| Kozela, E | 1 |
| Pilc, A | 1 |
| Zinkevich, VA | 1 |
| Grafova, VN | 1 |
| Kukushkin, ML | 1 |
| Kiselev, AV | 1 |
| Nikolajsen, L | 1 |
| Gottrup, H | 1 |
| Kristensen, AG | 1 |
| Jensen, TS | 1 |
| Chizh, BA | 1 |
| Reissmüller, E | 1 |
| Schlütz, H | 1 |
| Scheede, M | 1 |
| Haase, G | 1 |
| Englberger, W | 1 |
| Kiefer, RT | 1 |
| Suzuki, R | 1 |
| Matthews, EA | 1 |
| Dickenson, AH | 1 |
| Sang, CN | 1 |
| Booher, S | 1 |
| Gilron, I | 1 |
| Parada, S | 1 |
| Max, MB | 1 |
| Kilpatrick, GJ | 1 |
| Tilbrook, GS | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Memantine in the Treatment of Fibromyalgia: a Double-blind Randomized Trial[NCT01653457] | Phase 3 | 60 participants (Anticipated) | Interventional | 2012-09-30 | Not yet recruiting | ||
| Psychological Intervention and Physiotherapy With Medication Improves CRPS Patients Outcome[NCT02467556] | Phase 4 | 10 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
3 reviews available for memantine and Ache
| Article | Year |
|---|---|
Emerging molecular approaches to pain therapy.
Topics: Adrenergic Agonists; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinerg | 1999 |
Chronic Brain Failure.
Topics: Aged; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Cholinesterase Inhibitors; Delir | 2021 |
Memantine. Merz.
Topics: Animals; Clinical Trials as Topic; Dementia; Excitatory Amino Acid Antagonists; Glaucoma; Humans; Me | 2002 |
Trials
4 trials available for memantine and Ache
| Article | Year |
|---|---|
NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation.
Topics: Adult; Aged; Analgesics; Analysis of Variance; Brain Mapping; Cerebral Cortex; Double-Blind Method; | 2010 |
Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up.
Topics: Brain; Clinical Protocols; Cognition; Double-Blind Method; Drug Administration Schedule; Excitatory | 2013 |
Memantine (a N-methyl-D-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery: a randomized, double-blinded, cross-over study.
Topics: Adult; Aged; Amputation, Surgical; Amputation, Traumatic; Analgesics; Chronic Disease; Cross-Over St | 2000 |
Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials.
Topics: Adult; Aged; Dextromethorphan; Diabetic Neuropathies; Dose-Response Relationship, Drug; Double-Blind | 2002 |
Other Studies
24 other studies available for memantine and Ache
| Article | Year |
|---|---|
Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice.
Topics: Analgesics, Opioid; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 2014 |
Co-administration of memantine with epinephrine produces a marked peripheral action in intensifying and prolonging analgesia in response to local skin pinprick in rats.
Topics: Analgesics; Anesthetics, Combined; Anesthetics, Local; Animals; Epinephrine; Lidocaine; Male; Memant | 2014 |
Clonidine intensifies memantine cutaneous analgesia in response to local skin noxious pinprick in the rat.
Topics: Analgesia; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Injectio | 2015 |
Early use of memantine for neuropathic pain.
Topics: Humans; Memantine; Pain; Phantom Limb; Receptors, N-Methyl-D-Aspartate | 2008 |
Profound pain reduction after induction of memantine treatment in two patients with severe phantom limb pain.
Topics: Adult; Humans; Male; Memantine; Pain; Pain Measurement; Phantom Limb; Receptors, N-Methyl-D-Aspartat | 2008 |
Combined use of pregabalin and memantine in fibromyalgia syndrome treatment: a novel analgesic and neuroprotective strategy?
Topics: Analgesics; Chronic Disease; Drug Therapy, Combination; Fibromyalgia; gamma-Aminobutyric Acid; Human | 2009 |
Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Cyclopentanes; Diabetes Mellitus, Experime | 2009 |
Influence of memantine on nociceptive responses of the trigeminocervical complex after formalin injection.
Topics: Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Immunohistochemistry; Irritants; Male; Mem | 2012 |
Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine.
Topics: Analgesics, Opioid; Animals; Discrimination Learning; Disease Models, Animal; Dizocilpine Maleate; D | 2013 |
Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine.
Topics: Animals; Behavior, Animal; Dextromethorphan; Dose-Response Relationship, Drug; Edema; Excitatory Ami | 2002 |
Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test.
Topics: Animals; Behavior, Animal; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; | 2003 |
Society of neuroscience-33rd annual meeting: metabotropic glutamate receptors.
Topics: Animals; Antiparkinson Agents; Anxiety; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Hunting | 2004 |
Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury.
Topics: Amines; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Cyclohexanols; Disease Models, Animal | 2004 |
Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain.
Topics: Animals; Chronic Disease; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; | 2004 |
Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Body Weight; Carrageenan; Excitatory Amino Acid | 2004 |
Brain but not spinal NR2B receptor is responsible for the anti-allodynic effect of an NR2B subunit-selective antagonist CP-101,606 in a rat chronic constriction injury model.
Topics: Analgesics; Animals; Brain Chemistry; Constriction; Excitatory Amino Acid Antagonists; Injections, I | 2005 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb | 2008 |
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate | 1997 |
Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors.
Topics: Animals; Dextrorphan; Foot; Formaldehyde; Injections, Intradermal; Ketamine; Male; Memantine; Motor | 1998 |
Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice.
Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Drug Toler | 2000 |
Effect of akatinol (memantine) in central spinal pain syndrome.
Topics: Animals; Central Cord Syndrome; Dopamine Agents; Dose-Response Relationship, Drug; Memantine; Pain; | 2000 |
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil.
Topics: Analgesics; Animals; Decerebrate State; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino | 2001 |
Eliciting paresthesias for peripheral nerve block: a harmful clinical standard?
Topics: Analgesics, Non-Narcotic; Excitatory Amino Acid Antagonists; Humans; Memantine; Pain; Receptors, N-M | 2001 |
Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy.
Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagon | 2001 |