Page last updated: 2024-10-30

memantine and Ache

memantine has been researched along with Ache in 31 studies

Research Excerpts

ExcerptRelevanceReference
"A combination therapy of morphine with an NMDA-receptor antagonist might be more effective than morphine without a NMDA-receptor antagonist for the relief of neuropathic pain in patients with complex regional pain syndrome (CRPS)."9.14NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation. ( Birbaumer, N; Flor, H; Gustin, SM; Larbig, W; Lotze, M; Schmidt, AC; Schwarz, A; Sines, N; Veit, R, 2010)
"The authors studied patients with painful diabetic neuropathy (DN) and postherpetic neuralgia (PHN) in two crossover trials: (1) efficacy trial (dextromethorphan vs."9.10Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. ( Booher, S; Gilron, I; Max, MB; Parada, S; Sang, CN, 2002)
"In a randomized, double-blinded and cross-over study, the analgesic effect of memantine (a drug which reduces the excitability of sensitized neurons in the dorsal horn) was examined in 19 patients with chronic pain after nerve injury."9.09Memantine (a N-methyl-D-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery: a randomized, double-blinded, cross-over study. ( Gottrup, H; Jensen, TS; Kristensen, AG; Nikolajsen, L, 2000)
"To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats."7.72Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats. ( Back, SK; Han, HC; Hong, SK; Kim, YI; Lee, KS; Min, SS; Na, HS; Yoon, SJ; Yoon, YW; Zhang, GH, 2004)
"The present study examined the effects of local peripheral and systemic administration of three clinically used excitatory amino acid receptor antagonists (dextromethorphan, memantine, ketamine) on pain behaviors and edema produced by formalin (1."7.71Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. ( Reid, A; Sawynok, J, 2002)
"Fibromyalgia is a prevalent chronic rheumatic disease of great clinical importance."6.78Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up. ( Andrés, E; Arcega, R; Garcia-Campayo, J; López-del-Hoyo, Y; Magallon, R; Masluk, B; Olivan-Blázquez, B; Pérez-Yus, MC; Puebla, M; Roca, M, 2013)
"A combination therapy of morphine with an NMDA-receptor antagonist might be more effective than morphine without a NMDA-receptor antagonist for the relief of neuropathic pain in patients with complex regional pain syndrome (CRPS)."5.14NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation. ( Birbaumer, N; Flor, H; Gustin, SM; Larbig, W; Lotze, M; Schmidt, AC; Schwarz, A; Sines, N; Veit, R, 2010)
"The authors studied patients with painful diabetic neuropathy (DN) and postherpetic neuralgia (PHN) in two crossover trials: (1) efficacy trial (dextromethorphan vs."5.10Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. ( Booher, S; Gilron, I; Max, MB; Parada, S; Sang, CN, 2002)
"In a randomized, double-blinded and cross-over study, the analgesic effect of memantine (a drug which reduces the excitability of sensitized neurons in the dorsal horn) was examined in 19 patients with chronic pain after nerve injury."5.09Memantine (a N-methyl-D-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery: a randomized, double-blinded, cross-over study. ( Gottrup, H; Jensen, TS; Kristensen, AG; Nikolajsen, L, 2000)
"Memantine hydrochloride, an NMDA antagonist, was launched in Germany by Merz in 1989 for the treatment of dementia, an indication for which development was continuing in other markets."4.81Memantine. Merz. ( Kilpatrick, GJ; Tilbrook, GS, 2002)
"We investigated the influence of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine on pain pathways involving trigeminocervical complex (TCC) using a formalin injection model."3.78Influence of memantine on nociceptive responses of the trigeminocervical complex after formalin injection. ( Park, GE; Park, JW; Shin, HE; Suh, GI, 2012)
" The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine."3.74Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008)
"A series of mutual prodrugs derived from gabapentin, pregabalin, memantine, venlafaxine were synthesized and their pharmacological properties to treat neuropathic pain were investigated in a rat model of chronic sciatic nerve constriction injury (CCI)."3.72Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury. ( Bo-Hua, Z; He, L; Hong-Ju, Y; Jun-Wei, W; Nan, Z; Wei-Guo, S; Wei-Xiu, Y; Zhe-Hui, G; Zheng-Hua, G; Zhi-Pu, L; Zhong-Wei, J, 2004)
"To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats."3.72Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats. ( Back, SK; Han, HC; Hong, SK; Kim, YI; Lee, KS; Min, SS; Na, HS; Yoon, SJ; Yoon, YW; Zhang, GH, 2004)
"The present study examined the effects of local peripheral and systemic administration of three clinically used excitatory amino acid receptor antagonists (dextromethorphan, memantine, ketamine) on pain behaviors and edema produced by formalin (1."3.71Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. ( Reid, A; Sawynok, J, 2002)
" Ifenprodil and some other NMDA antagonists (MK-801, memantine) were tested in a model of inflammatory pain (Randall-Selitto) in rats."3.71Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil. ( Chizh, BA; Englberger, W; Haase, G; Reissmüller, E; Scheede, M; Schlütz, H, 2001)
"Fibromyalgia is a prevalent chronic rheumatic disease of great clinical importance."2.78Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up. ( Andrés, E; Arcega, R; Garcia-Campayo, J; López-del-Hoyo, Y; Magallon, R; Masluk, B; Olivan-Blázquez, B; Pérez-Yus, MC; Puebla, M; Roca, M, 2013)
"Dementia is a risk factor for delirium, and their symptoms can be similar."2.72Chronic Brain Failure. ( Wolak, JP, 2021)
" It is concluded that co-administration of Vit B12 and morphine could reduce tolerance to analgesic effect of morphine chronic administration and also reduce its withdrawal symptoms."1.40Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice. ( Etemad, L; Ghazanfari, S; Hosseinzadeh, H; Imenshahidi, M; Moshiri, M, 2014)
"Memantine is a N-methyl-D-aspartic acid receptor (NMDAR) channel blocker that binds to dizocilpine sites and appears well tolerated during chronic use."1.39Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine. ( Chen, Y; Evola, M; Young, AM, 2013)
" Here we determined the antinociceptive effect of chronic administration of neramexane and compared its effect with that of memantine and gabapentin in a rat model of diabetic neuropathic pain."1.35Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. ( Chen, SR; Pan, HL; Samoriski, G, 2009)
" Thus, studies on the prevention and management of chronic pain should focus on preemptive or long-term administration of NMDA receptor antagonists."1.32Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain. ( Aliev, K; Belozertseva, IV; Bespalov, AY; Danysz, W; Malyshkin, AA; Medvedev, IO; Parsons, CG; Sevostianova, NY; Sukhotina, IA; Zvartau, EE, 2004)
" As assessed by cumulative dose-response approach in the tail-flick test, administration of 10 mg kg(-1) morphine bid s."1.31Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice. ( Kozela, E; Pilc, A; Popik, P, 2000)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (9.68)18.2507
2000's20 (64.52)29.6817
2010's7 (22.58)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Williams, M1
Kowaluk, EA1
Arneric, SP1
Wolak, JP1
Ghazanfari, S1
Imenshahidi, M1
Etemad, L1
Moshiri, M1
Hosseinzadeh, H1
Chen, YW2
Tzeng, JI1
Pan, HJ1
Hung, CH2
Chen, YC1
Wang, JJ2
Wu, BT1
Chen, KT1
Liu, KS1
Buvanendran, A1
Kroin, JS1
Hackworth, RJ1
Tokarz, KA1
Fowler, IM1
Wallace, SC1
Stedje-Larsen, ET1
Recla, JM1
Sarantopoulos, CD1
Chen, SR1
Samoriski, G1
Pan, HL1
Gustin, SM1
Schwarz, A1
Birbaumer, N1
Sines, N1
Schmidt, AC1
Veit, R1
Larbig, W1
Flor, H1
Lotze, M1
Park, JW1
Suh, GI1
Shin, HE1
Park, GE1
Chen, Y1
Evola, M1
Young, AM1
Olivan-Blázquez, B1
Puebla, M1
Masluk, B1
Pérez-Yus, MC1
Arcega, R1
Andrés, E1
López-del-Hoyo, Y1
Magallon, R1
Roca, M1
Garcia-Campayo, J1
Sawynok, J1
Reid, A1
Berrino, L1
Oliva, P1
Massimo, F1
Aurilio, C1
Maione, S1
Grella, A1
Rossi, F1
Danysz, W2
Hong-Ju, Y1
He, L1
Wei-Guo, S1
Nan, Z1
Wei-Xiu, Y1
Zhong-Wei, J1
Jun-Wei, W1
Zheng-Hua, G1
Bo-Hua, Z1
Zhi-Pu, L1
Zhe-Hui, G1
Medvedev, IO1
Malyshkin, AA1
Belozertseva, IV1
Sukhotina, IA1
Sevostianova, NY1
Aliev, K1
Zvartau, EE1
Parsons, CG1
Bespalov, AY1
Zhang, GH1
Min, SS1
Lee, KS1
Back, SK1
Yoon, SJ1
Yoon, YW1
Kim, YI1
Na, HS1
Hong, SK1
Han, HC1
Nakazato, E1
Kato, A1
Watanabe, S1
Gil, DW1
Cheevers, CV1
Donello, JE1
Chaplan, SR1
Malmberg, AB1
Yaksh, TL1
Davidson, EM1
Carlton, SM1
Popik, P1
Kozela, E1
Pilc, A1
Zinkevich, VA1
Grafova, VN1
Kukushkin, ML1
Kiselev, AV1
Nikolajsen, L1
Gottrup, H1
Kristensen, AG1
Jensen, TS1
Chizh, BA1
Reissmüller, E1
Schlütz, H1
Scheede, M1
Haase, G1
Englberger, W1
Kiefer, RT1
Suzuki, R1
Matthews, EA1
Dickenson, AH1
Sang, CN1
Booher, S1
Gilron, I1
Parada, S1
Max, MB1
Kilpatrick, GJ1
Tilbrook, GS1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Memantine in the Treatment of Fibromyalgia: a Double-blind Randomized Trial[NCT01653457]Phase 360 participants (Anticipated)Interventional2012-09-30Not yet recruiting
Psychological Intervention and Physiotherapy With Medication Improves CRPS Patients Outcome[NCT02467556]Phase 410 participants (Actual)Interventional2011-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for memantine and Ache

ArticleYear
Emerging molecular approaches to pain therapy.
    Journal of medicinal chemistry, 1999, May-06, Volume: 42, Issue:9

    Topics: Adrenergic Agonists; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinerg

1999
Chronic Brain Failure.
    Emergency medicine clinics of North America, 2021, Volume: 39, Issue:2

    Topics: Aged; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Cholinesterase Inhibitors; Delir

2021
Memantine. Merz.
    Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:5

    Topics: Animals; Clinical Trials as Topic; Dementia; Excitatory Amino Acid Antagonists; Glaucoma; Humans; Me

2002

Trials

4 trials available for memantine and Ache

ArticleYear
NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation.
    Pain, 2010, Volume: 151, Issue:1

    Topics: Adult; Aged; Analgesics; Analysis of Variance; Brain Mapping; Cerebral Cortex; Double-Blind Method;

2010
Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up.
    Trials, 2013, Jan-03, Volume: 14

    Topics: Brain; Clinical Protocols; Cognition; Double-Blind Method; Drug Administration Schedule; Excitatory

2013
Memantine (a N-methyl-D-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery: a randomized, double-blinded, cross-over study.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Adult; Aged; Amputation, Surgical; Amputation, Traumatic; Analgesics; Chronic Disease; Cross-Over St

2000
Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials.
    Anesthesiology, 2002, Volume: 96, Issue:5

    Topics: Adult; Aged; Dextromethorphan; Diabetic Neuropathies; Dose-Response Relationship, Drug; Double-Blind

2002

Other Studies

24 other studies available for memantine and Ache

ArticleYear
Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice.
    Drug research, 2014, Volume: 64, Issue:3

    Topics: Analgesics, Opioid; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Dr

2014
Co-administration of memantine with epinephrine produces a marked peripheral action in intensifying and prolonging analgesia in response to local skin pinprick in rats.
    Neuroscience letters, 2014, Jun-27, Volume: 574

    Topics: Analgesics; Anesthetics, Combined; Anesthetics, Local; Animals; Epinephrine; Lidocaine; Male; Memant

2014
Clonidine intensifies memantine cutaneous analgesia in response to local skin noxious pinprick in the rat.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:3

    Topics: Analgesia; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Injectio

2015
Early use of memantine for neuropathic pain.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:4

    Topics: Humans; Memantine; Pain; Phantom Limb; Receptors, N-Methyl-D-Aspartate

2008
Profound pain reduction after induction of memantine treatment in two patients with severe phantom limb pain.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:4

    Topics: Adult; Humans; Male; Memantine; Pain; Pain Measurement; Phantom Limb; Receptors, N-Methyl-D-Aspartat

2008
Combined use of pregabalin and memantine in fibromyalgia syndrome treatment: a novel analgesic and neuroprotective strategy?
    Medical hypotheses, 2009, Volume: 73, Issue:2

    Topics: Analgesics; Chronic Disease; Drug Therapy, Combination; Fibromyalgia; gamma-Aminobutyric Acid; Human

2009
Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain.
    Neuropharmacology, 2009, Volume: 57, Issue:2

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Cyclopentanes; Diabetes Mellitus, Experime

2009
Influence of memantine on nociceptive responses of the trigeminocervical complex after formalin injection.
    Cephalalgia : an international journal of headache, 2012, Volume: 32, Issue:4

    Topics: Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Immunohistochemistry; Irritants; Male; Mem

2012
Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine.
    Psychopharmacology, 2013, Volume: 225, Issue:1

    Topics: Analgesics, Opioid; Animals; Discrimination Learning; Disease Models, Animal; Dizocilpine Maleate; D

2013
Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine.
    European journal of pharmacology, 2002, Aug-23, Volume: 450, Issue:2

    Topics: Animals; Behavior, Animal; Dextromethorphan; Dose-Response Relationship, Drug; Edema; Excitatory Ami

2002
Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test.
    European journal of pain (London, England), 2003, Volume: 7, Issue:2

    Topics: Animals; Behavior, Animal; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug;

2003
Society of neuroscience-33rd annual meeting: metabotropic glutamate receptors.
    IDrugs : the investigational drugs journal, 2004, Volume: 7, Issue:1

    Topics: Animals; Antiparkinson Agents; Anxiety; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Hunting

2004
Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury.
    Bioorganic & medicinal chemistry letters, 2004, May-17, Volume: 14, Issue:10

    Topics: Amines; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Cyclohexanols; Disease Models, Animal

2004
Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain.
    Neuropharmacology, 2004, Volume: 47, Issue:2

    Topics: Animals; Chronic Disease; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists;

2004
Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:1

    Topics: Animals; Arthritis, Experimental; Behavior, Animal; Body Weight; Carrageenan; Excitatory Amino Acid

2004
Brain but not spinal NR2B receptor is responsible for the anti-allodynic effect of an NR2B subunit-selective antagonist CP-101,606 in a rat chronic constriction injury model.
    Pharmacology, 2005, Volume: 73, Issue:1

    Topics: Analgesics; Animals; Brain Chemistry; Constriction; Excitatory Amino Acid Antagonists; Injections, I

2005
Transient allodynia pain models in mice for early assessment of analgesic activity.
    British journal of pharmacology, 2008, Volume: 153, Issue:4

    Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb

2008
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate

1997
Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors.
    Brain research, 1998, Feb-23, Volume: 785, Issue:1

    Topics: Animals; Dextrorphan; Foot; Formaldehyde; Injections, Intradermal; Ketamine; Male; Memantine; Motor

1998
Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice.
    British journal of pharmacology, 2000, Volume: 130, Issue:6

    Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Drug Toler

2000
Effect of akatinol (memantine) in central spinal pain syndrome.
    Bulletin of experimental biology and medicine, 2000, Volume: 129, Issue:5

    Topics: Animals; Central Cord Syndrome; Dopamine Agents; Dose-Response Relationship, Drug; Memantine; Pain;

2000
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil.
    Neuropharmacology, 2001, Volume: 40, Issue:2

    Topics: Analgesics; Animals; Decerebrate State; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino

2001
Eliciting paresthesias for peripheral nerve block: a harmful clinical standard?
    Anesthesia and analgesia, 2001, Volume: 92, Issue:3

    Topics: Analgesics, Non-Narcotic; Excitatory Amino Acid Antagonists; Humans; Memantine; Pain; Receptors, N-M

2001
Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy.
    Pain, 2001, Volume: 91, Issue:1-2

    Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagon

2001