memantine has been researched along with AIDS Dementia Complex in 11 studies
AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC)." | 5.10 | A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. ( Chang, L; Ernst, T; Gonzalez, RG; Jarvik, JG; Ketonen, LM; Kolson, DL; Kwok, EW; Lee, PL; Lenkinski, RE; Marra, CM; Meyerhoff, DJ; Navia, BA; Richards, TL; Schifitto, G; Simpson, D; Tang, CY; Yiannoutsos, CT, 2003) |
| "Memantine-treated HIVE mice showed significant improvements in synaptic function during frequency facilitation tests and LTP induced by high-frequency stimulation when compared with untreated animals." | 1.32 | Memantine protects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis. ( Anderson, ER; Gendelman, HE; Xiong, H, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakanishi, N | 1 |
| Kang, YJ | 1 |
| Tu, S | 1 |
| McKercher, SR | 1 |
| Masliah, E | 1 |
| Lipton, SA | 2 |
| Lindl, KA | 1 |
| Marks, DR | 1 |
| Kolson, DL | 2 |
| Jordan-Sciutto, KL | 1 |
| Lee, PL | 2 |
| Yiannoutsos, CT | 3 |
| Ernst, T | 3 |
| Chang, L | 3 |
| Marra, CM | 3 |
| Jarvik, JG | 2 |
| Richards, TL | 1 |
| Kwok, EW | 1 |
| Simpson, D | 1 |
| Tang, CY | 1 |
| Schifitto, G | 3 |
| Ketonen, LM | 1 |
| Meyerhoff, DJ | 2 |
| Lenkinski, RE | 2 |
| Gonzalez, RG | 1 |
| Navia, BA | 3 |
| Anderson, ER | 1 |
| Gendelman, HE | 1 |
| Xiong, H | 1 |
| Richards, T | 2 |
| Kolson, D | 2 |
| Miller, EN | 2 |
| Lenkinski, R | 1 |
| Gonzalez, G | 2 |
| Alisky, JM | 1 |
| Paul, RH | 1 |
| Singer, E | 1 |
| Jarvik, GJ | 1 |
| Price, R | 1 |
| Ellis, RJ | 1 |
| Cohen, RA | 1 |
| Nath, A | 1 |
| Haughey, NJ | 1 |
| Jones, M | 1 |
| Anderson, C | 1 |
| Bell, JE | 1 |
| Geiger, JD | 1 |
2 reviews available for memantine and AIDS Dementia Complex
| Article | Year |
|---|---|
HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities.
Topics: AIDS Dementia Complex; Animals; Anti-HIV Agents; Brain; HIV-1; Humans; Memantine; Minocycline; Neuro | 2010 |
Could cholinesterase inhibitors and memantine alleviate HIV dementia?
Topics: AIDS Dementia Complex; Antiretroviral Therapy, Highly Active; Cholinesterase Inhibitors; Excitatory | 2005 |
3 trials available for memantine and AIDS Dementia Complex
| Article | Year |
|---|---|
A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis.
Topics: AIDS Dementia Complex; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Excitatory Ami | 2003 |
A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age.
Topics: Adult; Age Factors; AIDS Dementia Complex; Anti-HIV Agents; Aspartic Acid; Basal Ganglia; Brain; Bra | 2004 |
Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity.
Topics: AIDS Dementia Complex; Antiparkinson Agents; Aspartic Acid; Basal Ganglia; Creatine; Female; Humans; | 2007 |
6 other studies available for memantine and AIDS Dementia Complex
| Article | Year |
|---|---|
Differential Effects of Pharmacologic and Genetic Modulation of NMDA Receptor Activity on HIV/gp120-Induced Neuronal Damage in an In Vivo Mouse Model.
Topics: AIDS Dementia Complex; Animals; Excitatory Amino Acid Antagonists; Genetic Therapy; HIV Envelope Pro | 2016 |
Memantine protects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis.
Topics: AIDS Dementia Complex; Animals; Electrophysiology; Encephalitis, Viral; Hippocampus; HIV-1; Immunohi | 2004 |
Treating AIDS dementia.
Topics: AIDS Dementia Complex; Anti-HIV Agents; Blood-Brain Barrier; Clinical Trials as Topic; Drug Therapy, | 1997 |
Stroke, Alzheimer's patients may benefit from AIDS dementia drug.
Topics: AIDS Dementia Complex; Alzheimer Disease; Cerebrovascular Disorders; Clinical Trials as Topic; Excit | 1997 |
Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine.
Topics: AIDS Dementia Complex; Brain; Calcium; Cell Survival; Cells, Cultured; Drug Synergism; Encephalitis; | 2000 |
Dementia trial underway.
Topics: AIDS Dementia Complex; Clinical Trials, Phase II as Topic; Controlled Clinical Trials as Topic; Doub | 2000 |