melphalan and Warts

melphalan has been researched along with Warts* in 2 studies

Other Studies

2 other study(ies) available for melphalan and Warts

Article	Year
Isolated limb infusion as a novel treatment for extensive plantar warts. Dermatology (Basel, Switzerland), 2009, Volume: 218, Issue:4 We describe the previously unreported use of isolated limb infusion (ILI) to treat extensive, bilateral plantar warts in a 54-year-old female. The warts had covered the weight-bearing surfaces of both feet for 10 years and had failed to respond to all previous treatments.. A standard ILI technique was used to infuse melphalan and actinomycin D to the left leg. Circulation was maintained for 30 min. The limb was warmed and upon completion of the procedure was markedly hypoxic and acidotic. The contralateral limb was treated 6 months later.. At 5 weeks, a partial response with 80% disease clearance was observed. Pain impeded mobilisation until desquamation occurred 6 weeks postoperatively. There was little regrowth at 6 months.. Although invasive, ILI may represent a viable treatment option for resistant human papilloma virus-induced warts on the peripheries. Further research into this potential treatment tool is warranted. Topics: Cytotoxins; Dactinomycin; Drug Therapy, Combination; Female; Foot Dermatoses; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Infusions, Parenteral; Melphalan; Middle Aged; Papillomavirus Infections; Warts	2009
Treatment of refractory hand warts by isolated limb infusion with melphalan and actinomycin D. The Australasian journal of dermatology, 2001, Volume: 42, Issue:2 We present an immunocompetent man with extensive warts on the hands, refractory to a number of conventional treatment modalities and causing substantial morbidity and impairment of normal function. Isolated limb infusion (regional intra-arterial chemotherapy) with melphalan and actinomycin D was performed, with substantial clearing of the warts within 2 months. Treatment-induced morbidity was limited to mild local erythema and oedema which resolved within 3 weeks. After 9 months' follow up, the patient had only a few residual warts and was able to resume normal activities. Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Follow-Up Studies; Hand Dermatoses; Humans; Immunocompetence; Infusions, Intra-Arterial; Male; Melphalan; Recurrence; Severity of Illness Index; Treatment Outcome; Warts	2001

Article

Year

Isolated limb infusion as a novel treatment for extensive plantar warts.

Dermatology (Basel, Switzerland), 2009, Volume: 218, Issue:4

We describe the previously unreported use of isolated limb infusion (ILI) to treat extensive, bilateral plantar warts in a 54-year-old female. The warts had covered the weight-bearing surfaces of both feet for 10 years and had failed to respond to all previous treatments.. A standard ILI technique was used to infuse melphalan and actinomycin D to the left leg. Circulation was maintained for 30 min. The limb was warmed and upon completion of the procedure was markedly hypoxic and acidotic. The contralateral limb was treated 6 months later.. At 5 weeks, a partial response with 80% disease clearance was observed. Pain impeded mobilisation until desquamation occurred 6 weeks postoperatively. There was little regrowth at 6 months.. Although invasive, ILI may represent a viable treatment option for resistant human papilloma virus-induced warts on the peripheries. Further research into this potential treatment tool is warranted.

Topics: Cytotoxins; Dactinomycin; Drug Therapy, Combination; Female; Foot Dermatoses; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Infusions, Parenteral; Melphalan; Middle Aged; Papillomavirus Infections; Warts

2009

Treatment of refractory hand warts by isolated limb infusion with melphalan and actinomycin D.

The Australasian journal of dermatology, 2001, Volume: 42, Issue:2

We present an immunocompetent man with extensive warts on the hands, refractory to a number of conventional treatment modalities and causing substantial morbidity and impairment of normal function. Isolated limb infusion (regional intra-arterial chemotherapy) with melphalan and actinomycin D was performed, with substantial clearing of the warts within 2 months. Treatment-induced morbidity was limited to mild local erythema and oedema which resolved within 3 weeks. After 9 months' follow up, the patient had only a few residual warts and was able to resume normal activities.

Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Follow-Up Studies; Hand Dermatoses; Humans; Immunocompetence; Infusions, Intra-Arterial; Male; Melphalan; Recurrence; Severity of Illness Index; Treatment Outcome; Warts

2001