melphalan and Ulcer

Topics: Amyloid beta-Protein Precursor; Amyloidosis; Antineoplastic Agents, Alkylating; Cardiomyopathies; Fatal Outcome; Humans; Immunoglobulin Light Chains; Male; Melphalan; Middle Aged; Penile Diseases; Penis; Prealbumin; Stem Cell Transplantation; Transplantation, Autologous; Ulcer

Topics: Antineoplastic Agents, Alkylating; Combined Modality Therapy; Female; Glucocorticoids; Granuloma; Humans; Melphalan; Middle Aged; Necrobiotic Disorders; Paraproteinemias; Prednisolone; Skin; Skin Transplantation; Ulcer; Xanthomatosis

We report a case of extramedullary plasmacytoma that appeared in an uncharacteristic manner as an ulcerative stomatitis affecting particularly the tongue and buccal mucosa. The lesions were associated with a transient lichenoid skin rash. The literature is reviewed and comparisons made between this tumor and the related plasma cell dyscrasias of multiple myeloma and monoclonal gammopathy.

Topics: Aged; Female; Humans; Immunoglobulin Heavy Chains; Immunoglobulin kappa-Chains; Lichenoid Eruptions; Melphalan; Mouth Neoplasms; Plasmacytoma; Stomatitis; Ulcer

Four patients with multiple myeloma refractory to conventional chemotherapy received high-dose melphalan. All experienced multiple oral complications. Extensive neutropenic ulceration and orofacial herpes simplex virus infection caused considerable morbidity in three patients during prolonged periods of neutropenia.

Topics: Adult; Female; Herpes Simplex; Humans; Male; Melphalan; Middle Aged; Mouth Diseases; Multiple Myeloma; Neutropenia; Opportunistic Infections; Stomatitis, Herpetic; Ulcer