melphalan and Thyroid-Neoplasms

A 61-year-old man with a primary thyroid plasmacytoma was studied. Intracytoplasmic monoclonal immunoglobulin (IgG-kappa) was demonstrated in tissue sections, using the immunoperoxidase technique. After histologic diagnosis of plasmacytoma, serum immunoelectrophoresis revealed a monoclonal component (IgG-kappa). Roentgenographic skeletal survey and bone marrow examination gave normal results. The patient received postoperative therapy with radiation and drugs. As of this writing, he is alive 20 months after diagnosis, without evidence of tumor.

Topics: Adult; Aged; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Immunoenzyme Techniques; Immunoglobulin G; Male; Melphalan; Middle Aged; Plasmacytoma; Prednisone; Thyroid Neoplasms; Thyroidectomy; Thyroiditis

Eleven patients with metastatic thyroid cancer received combination chemotherapy with doxorubicin, bleomycin, vincristine, and melphalan. Six of 11 patients responded, two with a minor response, three a partial, and one with a complete response. Most responses were brief (2-3 months), but the patient with a complete response is alive and free of disease at 60+ months. Toxicity was moderate and predominantly hematologic. Thyroid carcinoma is a moderately sensitive neoplasm with occasional prolonged responses to chemotherapy.

Topics: Adult; Aged; Bleomycin; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Melphalan; Middle Aged; Neoplasm Metastasis; Thyroid Neoplasms; Vincristine

Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Humans; Male; Melphalan; Methotrexate; Middle Aged; Thiotepa; Thyroid Neoplasms

Topics: Aged; Biopsy; Cyclophosphamide; Diagnosis, Differential; Frontal Bone; Humans; Immunoelectrophoresis; Immunoglobulin G; Iodine Radioisotopes; Male; Melphalan; Middle Aged; Multiple Myeloma; Neoplasm Metastasis; Parietal Bone; Plasmacytoma; Prednisone; Skull Neoplasms; Thyroid Neoplasms; Thyroidectomy; Vincristine

Topics: Adult; Amino Acid Sequence; Amyloid; Amyloidosis; Arthritis, Rheumatoid; Bence Jones Protein; Child; Female; Humans; Immunoglobulins; Melphalan; Microscopy, Electron; Multiple Myeloma; Staining and Labeling; Thyroid Neoplasms; X-Ray Diffraction