melphalan and Skin-Manifestations

In a patient with essential cryoglobulinemia with systemic, cutaneous, and neurologic manifestations and a mixed IgG-IgM cryoprotein, elimination of systemic and cutaneous disease manifestations, as well as notable reversal of neurologic impairment, followed therapy with melphalan. Levels of circulating cryoprotein decreased, but protein structure was unchanged by chemotherapy. Experience to date with alkylating agents suggests that this mode of treatment is the most effective currently available.

Topics: Cryoglobulins; Female; Humans; Immunoglobulin G; Immunoglobulin M; Melphalan; Middle Aged; Neurologic Manifestations; Paraproteinemias; Prednisone; Remission, Spontaneous; Skin Manifestations

Topics: Adult; Blood Protein Disorders; Blood Protein Electrophoresis; Blood Proteins; Cold Temperature; Female; Humans; Immune Sera; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Leg; Melphalan; Multiple Myeloma; Precipitin Tests; Prednisone; Purpura; Skin Manifestations

Topics: Adrenal Cortex Hormones; Adult; Amyloidosis; Autoimmune Diseases; Bence Jones Protein; Cold Temperature; Cryoglobulins; Humans; Hyperlipidemias; Immunoglobulin M; Male; Melphalan; Mucous Membrane; Multiple Myeloma; Mycosis Fungoides; Osteoporosis; Plasma Cells; Plasmacytoma; Purpura, Hyperglobulinemic; Pyoderma; Skin Manifestations; Skin Ulcer; Tongue; Xanthomatosis