melphalan has been researched along with Rupture--Spontaneous* in 2 studies
1 review(s) available for melphalan and Rupture--Spontaneous
| Article | Year |
|---|---|
Hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma in an infant: a rare case and review of the literature.
Spontaneous rupture of adrenal neuroblastoma is very rare in infants, in contrast to neonates. This report describes a 9-month-old boy presenting with acute hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma. MYCN oncogene amplification may be a predisposing factor for spontaneous rupture and bleeding of neuroblastoma. An appropriate surgical treatment for this condition must be discussed according to the patient's general state and the tumor features, such as staging, the origin, and local invasiveness. Topics: Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Crystalloid Solutions; Cyclophosphamide; Doxorubicin; Erythrocyte Transfusion; Genes, myc; Hematopoietic Stem Cell Transplantation; Hemoperitoneum; Humans; Infant; Isotonic Solutions; Male; Melphalan; Neuroblastoma; Remission Induction; Risk Factors; Rupture, Spontaneous; Shock, Hemorrhagic; Thiotepa; Transplantation, Autologous; Vincristine | 2012 |
1 other study(ies) available for melphalan and Rupture--Spontaneous
| Article | Year |
|---|---|
Spontaneous rupture of the liver in a patient with systemic AL amyloidosis undergoing treatment with high-dose melphalan and autologous stem cell transplantation: a case report with literature review.
A 55-year-old woman with primary Immunoglobulin light chain (AL) systemic amyloidosis died due to spontaneous rupture of her liver following treatment with high-dose melphalan and autologous stem cell transplant (HDM/SCT). She was first diagnosed after developing nephrotic-range proteinuria. Spontaneous rupture of her liver occurred 10 days after treatment with HDM/SCT and was complicated by septic shock. She was not eligible for surgical intervention and died shortly after. Amyloid fibrils were extracted from the autopsied liver sample (05-135L) and the biochemical nature of the fibrils was analyzed using electrophoretic and immunohistochemical techniques. Our testing showed that the fibrils were composed of immunoglobulin lambda light chains that were not glycosylated. While the liver is often involved in AL amyloidosis, this is the first documented case of a spontaneous hepatic rupture in a patient during treatment with HDM/SCT. A literature review of spontaneous liver rupture in patients with amyloidosis is presented. Topics: Amyloid; Amyloidosis; Electrophoresis, Polyacrylamide Gel; Fatal Outcome; Female; Humans; Immunohistochemistry; Liver Diseases; Melphalan; Middle Aged; Rupture, Spontaneous; Stem Cell Transplantation; Transplantation Conditioning | 2009 |