melphalan and Purpura--Thrombotic-Thrombocytopenic

Thrombotic thrombocytopenic purpura (TTP) is a particularly serious form of thrombotic microangiopathy (TMA) due to the risk of multiple organ dysfunction. Several etiological factors such as infection, auto-immune disease, certain medications and cancers have been associated with TTP.. A 74-year-old hypertensive woman with a history of thromboembolic disease was hospitalized for acute kidney injury (AKI) associated with pneumonia. Initial investigations were suggestive of Pneumocystis jirovecii infection and myeloma cast nephropathy. Several days later, the patient presented features of TTP. Von Willebrand factor-cleaving protease activity was less than 5% with a high level of IgG antibody directed against ADAMTS13. Treatment consisted of monthly 4-day cycles of dexamethasone and melphalan in combination with plasmapheresis and resulted in a favorable outcome. Three years after ceasing treatment, the patient presented no signs of hemolysis, but required chronic hemodialysis.. The association of TMA, especially TTP, and multiple myeloma is exceptional. The authors report such a case that induced irreversible renal damage, but with stable clinical and laboratory parameters with a follow-up of 4 years.

Topics: Acute Kidney Injury; ADAM Proteins; ADAMTS13 Protein; Aged; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Dexamethasone; Female; Humans; Immunoglobulin G; Melphalan; Multiple Myeloma; Plasmapheresis; Purpura, Thrombotic Thrombocytopenic; Renal Dialysis; Time Factors; Treatment Outcome

Topics: Adult; Bone Marrow Transplantation; Cyclophosphamide; Epilepsy, Tonic-Clonic; Fever; Graft vs Host Disease; Humans; Leukemia, Erythroblastic, Acute; Male; Melphalan; Mitoxantrone; Multiple Myeloma; Purpura, Thrombotic Thrombocytopenic; Whole-Body Irradiation