melphalan and Pulmonary-Embolism

melphalan has been researched along with Pulmonary-Embolism* in 2 studies

Other Studies

2 other study(ies) available for melphalan and Pulmonary-Embolism

Article	Year
Results of hyperthermic perfusion for melanoma of the extremities. Surgery, gynecology & obstetrics, 1975, Volume: 140, Issue:3 Our studies show that the malignant melanoma cell in human beings is more sensitive to the lethal effect of heat than its normal counterpart, the melanocyte. Malignant melanoma of the extremities presents unique problems; at times, local control can be extremely difficult. The addition of heat to regional perfusion with melphalan has dramatically improved the objective response of melanoma. Complications rise as the tempreature and duration of perfusion increase. These risks must be weighed carefully against the volume and extent of tumor. One hundred and eighty-five hyperthermic perfusions have been perfomed on 165 patients. When done with meticulous attention to details, this procedure is accompanied by minimal morbidity and mortality. Hyperthermic perfusion is currently the best treatment for recurrent melanoma of the extremities and has almost eliminated the necessity for amputation. Perfusion is recommended as a prophylactic measure for the more deeply invasive primary lesions. It reduces the incidence of regional recurrence. A retrospective statistical analysis of survival rates of patients treated with nonheated and heated perfusion for recurrent melanoma, State IIIA, was conducted. If the experience of the heated group continues, which from a clinical standpoint appears likely, then a striking advantage of heated perfusion over nonheated perfusion will be demonstrated. This superiority in survival rates for the heated group is now three to one or 300 per cent. The most reasonable explanation for the improvement in survival time of patients in State IIIA is stimulation of the immune response. As a result of our experience with heated perfusion of limbs, we are investigating the possibility that systemic hyperthermia may enhance the antitumor effects of various chemotherapeutic agents on melanoma. Topics: Acute Kidney Injury; Age Factors; Aged; Cell Line; Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Hot Temperature; Humans; Hyperthermia, Induced; Male; Melanocytes; Melanoma; Melphalan; Neoplasm Metastasis; Pulmonary Embolism; Recurrence; Sex Factors	1975
Respiratory insufficiency in the dog induced by pulmonary microembolism and inhibition of fibrinolysis. Effect of defibrinogenation, leucopenia and thrombocytopenia. Acta chirurgica Scandinavica, 1974, Volume: 140, Issue:4 Topics: Afibrinogenemia; Animals; Antifibrinolytic Agents; Blood Cell Count; Blood Platelets; Chromium Radioisotopes; Coagulase; Cyclohexanecarboxylic Acids; Dogs; Female; Fibrinogen; Hematocrit; Immune Sera; Iodine Radioisotopes; Leukocyte Count; Leukopenia; Male; Melphalan; Oxygen; Partial Pressure; Pulmonary Embolism; Rabbits; Respiratory Insufficiency; Thrombin; Thrombocytopenia	1974

Article

Year

Results of hyperthermic perfusion for melanoma of the extremities.

Surgery, gynecology & obstetrics, 1975, Volume: 140, Issue:3

Our studies show that the malignant melanoma cell in human beings is more sensitive to the lethal effect of heat than its normal counterpart, the melanocyte. Malignant melanoma of the extremities presents unique problems; at times, local control can be extremely difficult. The addition of heat to regional perfusion with melphalan has dramatically improved the objective response of melanoma. Complications rise as the tempreature and duration of perfusion increase. These risks must be weighed carefully against the volume and extent of tumor. One hundred and eighty-five hyperthermic perfusions have been perfomed on 165 patients. When done with meticulous attention to details, this procedure is accompanied by minimal morbidity and mortality. Hyperthermic perfusion is currently the best treatment for recurrent melanoma of the extremities and has almost eliminated the necessity for amputation. Perfusion is recommended as a prophylactic measure for the more deeply invasive primary lesions. It reduces the incidence of regional recurrence. A retrospective statistical analysis of survival rates of patients treated with nonheated and heated perfusion for recurrent melanoma, State IIIA, was conducted. If the experience of the heated group continues, which from a clinical standpoint appears likely, then a striking advantage of heated perfusion over nonheated perfusion will be demonstrated. This superiority in survival rates for the heated group is now three to one or 300 per cent. The most reasonable explanation for the improvement in survival time of patients in State IIIA is stimulation of the immune response. As a result of our experience with heated perfusion of limbs, we are investigating the possibility that systemic hyperthermia may enhance the antitumor effects of various chemotherapeutic agents on melanoma.

Topics: Acute Kidney Injury; Age Factors; Aged; Cell Line; Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Hot Temperature; Humans; Hyperthermia, Induced; Male; Melanocytes; Melanoma; Melphalan; Neoplasm Metastasis; Pulmonary Embolism; Recurrence; Sex Factors

1975

Respiratory insufficiency in the dog induced by pulmonary microembolism and inhibition of fibrinolysis. Effect of defibrinogenation, leucopenia and thrombocytopenia.

Acta chirurgica Scandinavica, 1974, Volume: 140, Issue:4

Topics: Afibrinogenemia; Animals; Antifibrinolytic Agents; Blood Cell Count; Blood Platelets; Chromium Radioisotopes; Coagulase; Cyclohexanecarboxylic Acids; Dogs; Female; Fibrinogen; Hematocrit; Immune Sera; Iodine Radioisotopes; Leukocyte Count; Leukopenia; Male; Melphalan; Oxygen; Partial Pressure; Pulmonary Embolism; Rabbits; Respiratory Insufficiency; Thrombin; Thrombocytopenia

1974