melphalan has been researched along with Leukoencephalopathy--Progressive-Multifocal* in 2 studies
1 review(s) available for melphalan and Leukoencephalopathy--Progressive-Multifocal
| Article | Year |
|---|---|
Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy.
A patient with a stage IV mantle cell lymphoma (according to the REAL classification) was treated with high-dose chemotherapy and autologous bone marrow transplantation. One year later while on alpha-interferon immunotherapy she suffered from progressive loss of short-term memory and reported difficulties in recognizing objects. Magnetic resonance imaging (MRI) showed a vast ring-enhancing lesion of the left postcentral parietal area. Serial stereotactic biopsies disclosed progressive multifocal leukoencephalopathy without JC-virus in the cerebrospinal fluid. Therapy with subcutaneous interleukin-2 (IL-2) every other day and intrathecal cytarabine once a week was started. After 4 weeks the patient refused further treatment. Nevertheless her condition improved over the next 8 months and MRI scans showed a marked improvement in the lesions. Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dexamethasone; Encephalitis; Etoposide; Female; Humans; Immunoglobulins, Intravenous; Immunosuppression Therapy; Injections, Spinal; Interferon-alpha; Interleukin-12; Leukoencephalopathy, Progressive Multifocal; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Melphalan; Memory Disorders; Middle Aged; Podophyllotoxin; Transplantation Conditioning; Transplantation, Autologous; Vincristine | 1999 |
1 other study(ies) available for melphalan and Leukoencephalopathy--Progressive-Multifocal
| Article | Year |
|---|---|
Leukoencephalopathy in multiple myeloma: two case reports.
No case of leukoencephalopathy has been reported associated with multiple myeloma.. We report on two patients with a very rare association of leukoencephalopathy and multiple myeloma revealed by cognitive impairment.. Chemotherapy has improved neurological and biological signs. Radiological abnormalities have been stabilized.. The authors suggest that leukoencephalopathy is probably a direct cerebral expression of malignant gammopathy. Topics: Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Female; Humans; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Imaging; Male; Melphalan; Multiple Myeloma; Polyneuropathies; Prednisone | 1999 |