melphalan and Hypertrophy

Light chain deposition disease is a systemic disorder characterised by tissue deposition of monoclonal immunoglobulin light chains without tinctorial properties. It has been exceptionally reported with salivary involvement mimicking Sjögren's syndrome and peripheral neuropathy.. We report a case of light chain deposition disease associated with plasma cell dyscrasia presenting as sicca syndrome with salivary glands hypertrophy and polyneuropathy successfully treated by high dose melphalan and autologous blood stem transplantation.. Light chain deposition disease should be recognized as an aetiology of sicca syndrome and peripheral neuropathy. Further studies should assess the prevalence of sicca syndrome in light chain deposition disease and better characterise the neurological manifestations.

Topics: Biopsy; Diagnosis, Differential; Electromyography; Female; Humans; Hypertrophy; Immunoglobulin kappa-Chains; Melphalan; Paraproteinemias; Peripheral Nervous System Diseases; Salivary Glands; Sialography; Sjogren's Syndrome; Stem Cell Transplantation; Tomography, X-Ray Computed; Transplantation, Autologous

Topics: Alkylation; Animals; Carcinoma, Ehrlich Tumor; Cell Nucleolus; DNA, Neoplasm; Female; Hypertrophy; Male; Melphalan; Mice; Microscopy, Electron; Mitosis; Nucleoproteins; Polyploidy

Topics: Adenofibroma; Animals; Breast Diseases; Breast Neoplasms; Fibroadenoma; Humans; Hypertrophy; Mammary Glands, Animal; Mammary Glands, Human; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Melphalan; Pharmacology; Rats; Research; Toxicology

Topics: Cardiomegaly; DNA; Heart; Hypertrophy; Melphalan; Pharmacology; Rats; Research

Topics: Antineoplastic Agents; Aziridines; Breast Neoplasms; Cell Nucleus; Coloring Agents; Cyclophosphamide; Female; Hodgkin Disease; Humans; Hyperplasia; Hypertrophy; Mathematics; Melphalan; Ovarian Neoplasms; Pathology; Staining and Labeling; Thiotepa; Triethylenemelamine; Uterine Neoplasms; Vaginal Smears